Patents by Inventor Richard A. Schnettler

Richard A. Schnettler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing 2,3-dihydro-benzofuranol derivatives
    Patent number: 5698696
    Abstract: This invention relates to a novel process for preparing 2,3-dihydro-benzofuranol derivatives and to the novel intermediates produced thereby.
    Type: Grant
    Filed: March 7, 1996
    Date of Patent: December 16, 1997
    Assignee: Hoechst Marion Roussel, Inc.
    Inventors: Gilbert Marciniak, Richard A. Schnettler, Timothy A. Ayers, Damian J. Krysan
  • 5-acyl-2-(1H)-pyridinoes
    Patent number: 5428045
    Abstract: Novel 5-acyl-2-(1H)pyridinones and their use as cardiotonic agents. Typical of the compounds is 5-acetyl-1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile which is prepared by condensing anionic cyano acetamide with 3-[(dimethylamino)methylenyl]-2,4-pentanedione in an inert organic solvent.
    Type: Grant
    Filed: August 25, 1993
    Date of Patent: June 27, 1995
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Winton D. Jones, Richard C. Dage, Richard A. Schnettler
  • Alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones
    Patent number: 5212314
    Abstract: This invention relates to alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones and to their use as cardiotonic agents useful in treating cardiac failure, and to the process useful in the preparation thereof.
    Type: Grant
    Filed: June 16, 1992
    Date of Patent: May 18, 1993
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Winton D. Jones, Richard A. Schnettler, Richard C. Dage
  • Alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones
    Patent number: 5212315
    Abstract: This invention relates to alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones and to their use as cardiotonic agents useful in treating cardiac failure, and to the process useful in the preparation thereof.
    Type: Grant
    Filed: July 29, 1991
    Date of Patent: May 18, 1993
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Winton D. Jones, Richard C. Dage, Richard A. Schnettler
  • 5-Acyl-2-(1H)-pyridinones useful for treating cardiac failure
    Patent number: 5118696
    Abstract: Novel 5-acyl-2-(1H)pyrdinones and their use as cardiotonic agents. Typical of the compounds is 5-acetyl-1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile which is prepared by condensing anionic cyano acetamide with 3-[(dimethylamino)methylenyl]-2,4-pentanedione in an inert organic solvent.
    Type: Grant
    Filed: November 9, 1990
    Date of Patent: June 2, 1992
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Winton D. Jones, Richard A. Schnettler, Richard C. Dage
  • Certain alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones
    Patent number: 5043449
    Abstract: This invention relates to alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones and to their use as cardiotonic agents useful in treating cardiac failure, and to the process useful in the preparation thereof.
    Type: Grant
    Filed: February 8, 1990
    Date of Patent: August 27, 1991
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Winton D. Jones, Richard A. Schnettler, Richard C. Dage
  • Method for reducing injury with imidazol-2-thionecarboxamides
    Patent number: 5002961
    Abstract: Certain 2-oxo- and 2-thioxoimidazol-4-carboxamides are reported to reduce reperfusion injury which is the injury which occurs when molecular oxygen is reintroduced into an ischemic tissue. These compounds could be used to prevent much of the damage which occurs to the heart of a heart attack victim.
    Type: Grant
    Filed: June 28, 1990
    Date of Patent: March 26, 1991
    Assignee: Merrell Dow Pharmaceuticals
    Inventors: Richard C. Dage, Richard A. Schnettler
  • Method of reducing reperfusion injury with imidazol-2-thiones
    Patent number: 4999365
    Abstract: Certain imidazol-2-thiones are reported to reduce reperfusion injury which is the injury which occurs when molecular oxygen is reintroduced into an ischemic tissue. These compounds could be used to prevent much of the damage which occurs to the heart of a heart attack victim.
    Type: Grant
    Filed: December 11, 1989
    Date of Patent: March 12, 1991
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Richard C. Dage, Richard A. Schnettler
  • Certain 5-acyl-2-(1H)-pyridinones useful in treating cardiac failure
    Patent number: 4992452
    Abstract: Novel 5-acyl-2-(1H)-pyridinones and their use as cardiotonic agents. Typical of the compounds is 5-acetyl-1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile which is prepared by condensing anionic cyano acetamide with 3-[(dimethylamino)methylenyl]-2,4-pentanedione in an inert organic solvent.
    Type: Grant
    Filed: May 1, 1989
    Date of Patent: February 12, 1991
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Winton D. Jones, Richard C. Dage, Richard A. Schnettler
  • Cardiotonic aroylthiazolones
    Patent number: 4927939
    Abstract: Aroylthiazolones enhance myocardial contractile force and are useful as cardiotonics in the treatment of heart failure.
    Type: Grant
    Filed: March 17, 1987
    Date of Patent: May 22, 1990
    Assignee: Merrell Dow Pharmaceuticals
    Inventors: J. Martin Grisar, Richard C. Dage, Richard A. Schnettler
  • Novel alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones
    Patent number: 4920229
    Abstract: This invention relates to alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones and to their use as cardiotonic agents useful in treating cardiac failure, and to the process useful in the preparation thereof.
    Type: Grant
    Filed: March 10, 1989
    Date of Patent: April 24, 1990
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Winton D. Jones, Richard C. Dage, Richard A. Schnettler
  • Reducing reperfusion injury with 1,3-dihydro-4-methyl-5-(4-methylthio)benzoyl)-2H-imidazol-2-thione
    Patent number: 4868197
    Abstract: A sulfur analog of enoximone, 1,3-dihydro-4-methyl-5-[4-(methylthio)benzoyl]-2H-imidazol-2-thione, is reported to reduce reperfusion injury, the injry which occurs when molecular oxygen is reintroduced into an ischemic tissue. The compound could be used to prevent much of the damage which occurs to the heart of a heart attack victim.
    Type: Grant
    Filed: March 21, 1988
    Date of Patent: September 19, 1989
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Richard A. Schnettler, Richard C. Dage, J. Martin Grisar, Frank P. Palopoli
  • Cardiotonic alkanoyl and aroyl oxazolones
    Patent number: 4866182
    Abstract: Alkanoyl or aroyl oxazolones enhance myocardial contractile force and are useful as cardiotonics in the treatment of heart failure.
    Type: Grant
    Filed: February 18, 1988
    Date of Patent: September 12, 1989
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Richard A. Schnettler, Winton D. Jones, Richard C. Dage
  • Cardiotonic phenyl oxazolones
    Patent number: 4866085
    Abstract: Phenyloxazolones are useful as cardiotonics in the treatment of heart failure and enhance cardiac function.
    Type: Grant
    Filed: November 24, 1987
    Date of Patent: September 12, 1989
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Richard A. Schnettler, George P. Claxton, Winton D. Jones, Jr.
  • Certain 3-carboxylate or 3-carbamyl-5-acyl-2-(1H)-pyridinones having cardiotonic properties
    Patent number: 4853395
    Abstract: Novel 5-acyl-2-(1H)pyridinones and their use as cardiotonic agents. Typical of the compounds is 5-acetyl-1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile which is prepared by condensing anionic cyano acetamide with 3-[(dimethylamino)methylenyl]-2,4-pentanedione in an inert organic solvent.
    Type: Grant
    Filed: November 17, 1987
    Date of Patent: August 1, 1989
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Winton D. Jones, Richard A. Schnettler, Richard C. Dage
  • Novel alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones
    Patent number: 4849522
    Abstract: This invention relates to alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones and to their use as cardiotonic agents useful in treating cardiac failure, and to the process useful in the preparation thereof.
    Type: Grant
    Filed: March 10, 1988
    Date of Patent: July 18, 1989
    Assignee: Merrell Dow Pharmaceuticals
    Inventors: Winton D. Jones, Richard C. Dage, Richard A. Schnettler
  • Cardiotonic tricyclic oxazolones
    Patent number: 4803210
    Abstract: Tricyclic oxazolones enhance myocardial contractile force and are useful as cardiotonics in the treatment of heart failure.
    Type: Grant
    Filed: April 14, 1988
    Date of Patent: February 7, 1989
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Winton D. Jones, Richard A. Schnettler, George P. Claxton, Richard C. Dage
  • Preparation of 1,3-dihydro-4-pyridoyl-2H-imidazol-2-ones
    Patent number: 4803278
    Abstract: 1,3-Dihydro-4-pyridoyl-2H-imidazol-2-ones are prepared in a three step process by(a) reducing 1-pyridyl-1,3-deketo-2-oximinoalkanes to produce 1-pyridyl-1-hydroxy-2-amine-3-ketoalkanes;(b) reacting the thus produced hydroxyaminoketone with cyanate ion to produce a 1,3-dihydro-4-hydroxy(pyridyl)methyl-2H-imidazol-2-one; and(c) oxidizing the thus produced hydroxymethyl compound to yield the desired product.
    Type: Grant
    Filed: October 7, 1986
    Date of Patent: February 7, 1989
    Assignee: Merrell Dow Pharmaceuticals, Inc.
    Inventors: Richard A. Schnettler, Chi-Hsin R. King
  • Cardiotonic 5-benzoyl-1,2-dihydro-2-oxo-3-pyridinecarboxylates
    Patent number: 4769380
    Abstract: Novel 3-carboxy- and 3-carbalkoxy-5-benzoyl-2(1H)-pyridinones as well as the pharmaeutically acceptable salts thereof are cardiotonic agents useful in the treatment of heart failure.
    Type: Grant
    Filed: July 31, 1986
    Date of Patent: September 6, 1988
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Winton D. Jones, Jr., Richard A. Dage, Richard A. Schnettler
  • Cardiotonic alkanoylthiazolones
    Patent number: 4762849
    Abstract: Novel alkanoylthiazolones enhance myocardial contractile force and are useful as cardiotonics in the treatment of heart failure.
    Type: Grant
    Filed: October 15, 1985
    Date of Patent: August 9, 1988
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: J. Martin Grisar, Richard C. Dage, Richard A. Schnettler