Patents by Inventor Richard A. Silva

Richard A. Silva has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF PREPARING CYTOTOXIC BENZODIAZEPINE DERIVATIVES
    Publication number: 20210171547
    Abstract: The invention relates to novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.
    Type: Application
    Filed: November 23, 2020
    Publication date: June 10, 2021
    Inventors: Baudouin Gérard, Manami Shizuka, Michael Louis Miller, Richard A. Silva
  • METHODS OF PREPARING CYTOTOXIC BENZODIAZEPINE DERIVATIVES
    Publication number: 20210139510
    Abstract: The invention provides novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.
    Type: Application
    Filed: October 22, 2020
    Publication date: May 13, 2021
    Inventors: Baudouin Gérard, Richard A. Silva, Michael Louis Miller, Manami Shizuka
  • METHODS OF PREPARING CYTOTOXIC BENZODIAZEPINE DERIVATIVES
    Publication number: 20210122768
    Abstract: The invention provides novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.
    Type: Application
    Filed: October 1, 2020
    Publication date: April 29, 2021
    Inventors: Michael Reardon, Richard A. Silva
  • Methods of preparing substituted 12a,13-dihydro-6H-benzo[5,6][1,4]diazepino[1,2-a]indoles
    Patent number: 10968228
    Abstract: The invention provides novel methods for preparing indolinobenzodiazepine monomer compounds of formula (I) below and their synthetic precursors:
    Type: Grant
    Filed: September 4, 2019
    Date of Patent: April 6, 2021
    Assignee: IMMUNOGEN, INC.
    Inventors: Baudouin Gérard, Richard A. Silva, Michael Louis Miller, Manami Shizuka
  • Methods of preparing cytotoxic benzodiazepine derivatives
    Patent number: 10913713
    Abstract: The invention provides novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.
    Type: Grant
    Filed: November 11, 2019
    Date of Patent: February 9, 2021
    Assignee: IMMUNOGEN, INC.
    Inventors: Michael Reardon, Richard A. Silva
  • Methods of preparing cytotoxic benzodiazepine derivatives
    Patent number: 10899775
    Abstract: The invention relates to novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.
    Type: Grant
    Filed: September 12, 2018
    Date of Patent: January 26, 2021
    Assignee: IMMUNOGEN, INC.
    Inventors: Baudouin Gérard, Manami Shizuka, Michael Louis Miller, Richard A. Silva
  • Methods of preparing cytotoxic benzodiazepine derivatives
    Patent number: 10851117
    Abstract: The invention provides novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.
    Type: Grant
    Filed: November 11, 2019
    Date of Patent: December 1, 2020
    Assignee: IMMUNOGEN, INC.
    Inventors: Michael Reardon, Richard A. Silva
  • Methods of preparing cytotoxic benzodiazepine derivatives
    Patent number: 10844078
    Abstract: The invention provides novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.
    Type: Grant
    Filed: June 17, 2019
    Date of Patent: November 24, 2020
    Assignee: IMMUNOGEN, INC.
    Inventors: Baudouin Gérard, Richard A. Silva, Michael Louis Miller, Manami Shizuka
  • Methods of preparing cytotoxic benzodiazepine derivatives
    Patent number: 10787463
    Abstract: The invention relates to novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.
    Type: Grant
    Filed: June 6, 2019
    Date of Patent: September 29, 2020
    Assignee: IMMUNOGEN, INC.
    Inventors: Baudouin Gérard, Manami Shizuka, Michael Louis Miller, Richard A. Silva
  • RISK REVERSAL INDEX
    Publication number: 20200279327
    Abstract: A computer-implemented method and a computer system for a risk reversal index comprises a computer processor that is configured to sell at least one out-of-the-money put option on an underlying index, calculate a premium from the sale of the out-of-the- money put option, use the premium to buy at least one out-of-the-money call option on the underlying index, and invest any remaining premium after purchase of the out-of-the-money call option in a cash-equivalent position having a value. The out-of-the-money put option is sold and the out-of-the-money call option is bought on a roll date.
    Type: Application
    Filed: May 23, 2014
    Publication date: September 3, 2020
    Applicant: WELLS FARGO BANK, N.A.
    Inventors: Philip S. Douthit, Benjamin R. Adams, Richard Silva, William Threadgill, Jared Knote
  • METHODS OF PREPARING CYTOTOXIC BENZODIAZEPINE DERIVATIVES
    Publication number: 20200172481
    Abstract: The invention provides novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.
    Type: Application
    Filed: November 11, 2019
    Publication date: June 4, 2020
    Inventors: Michael Reardon, Richard A. Silva
  • METHODS OF PREPARING CYTOTOXIC BENZODIAZEPINE DERIVATIVES
    Publication number: 20200172555
    Abstract: The invention provides novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.
    Type: Application
    Filed: November 11, 2019
    Publication date: June 4, 2020
    Inventors: Michael Reardon, Richard A. Silva
  • METHODS OF PREPARING INDOLINOBENZODIAZEPINE DERIVATIVES
    Publication number: 20200109145
    Abstract: The invention provides novel methods for preparing indolinobenzodiazepine monomer compounds and their synthetic precursors.
    Type: Application
    Filed: September 4, 2019
    Publication date: April 9, 2020
    Inventors: Baudouin Gérard, Richard A. Silva, Michael Louis Miller, Manami Shizuka
  • METHODS OF PREPARING CYTOTOXIC BENZODIAZEPINE DERIVATIVES
    Publication number: 20200017526
    Abstract: The invention relates to novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.
    Type: Application
    Filed: June 21, 2019
    Publication date: January 16, 2020
    Inventors: Baudouin Gérard, Manami Shizuka, Michael Louis Miller, Richard A. Silva
  • METHODS OF PREPARING CYTOTOXIC BENZODIAZEPINE DERIVATIVES
    Publication number: 20200002360
    Abstract: The invention provides novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.
    Type: Application
    Filed: June 17, 2019
    Publication date: January 2, 2020
    Inventors: Baudouin Gérard, Richard A. Silva, Michael Louis Miller, Manami Shizuka
  • METHODS OF PREPARING CYTOTOXIC BENZODIAZEPINE DERIVATIVES
    Publication number: 20190389883
    Abstract: The invention relates to novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.
    Type: Application
    Filed: June 6, 2019
    Publication date: December 26, 2019
    Inventors: Baudouin Gérard, Manami Shizuka, Michael Louis Miller, Richard A. Silva
  • Methods for preparing substituted 12a,13-dihydro-6H-benzo[5,6][1,4]diazepino[1,2-a]indol-6-ones
    Patent number: 10442809
    Abstract: The invention provides novel methods for preparing indolinobenzodiazepine monomer compounds and their synthetic precursors.
    Type: Grant
    Filed: April 19, 2018
    Date of Patent: October 15, 2019
    Assignee: IMMUNOGEN, INC.
    Inventors: Baudouin Gérard, Richard A. Silva, Michael Louis Miller, Manami Shizuka
  • METHODS FOR ANTIBODY DRUG CONJUGATION, PURIFICATION, AND FORMULATION
    Publication number: 20190270769
    Abstract: Methods of producing, purifying, and formulating antibody drug conjugates (ADCs) are provided herein. The methods use continuous conjugation processes, single-pass tangential flow filtration, countercurrent diafiltration, and/or in-line process automation technologies. The methods decrease process times and costs and improve product consistency.
    Type: Application
    Filed: January 11, 2019
    Publication date: September 5, 2019
    Inventors: Daniel F. Milano, Michael R. Reardon, Richard A. Silva, Benjamin M. Hutchins, Robert W. Herbst
  • Methods of preparing cytotoxic benzodiazepine derivatives
    Patent number: 10392407
    Abstract: The invention relates to novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.
    Type: Grant
    Filed: January 3, 2018
    Date of Patent: August 27, 2019
    Assignee: IMMUNOGEN, INC.
    Inventors: Baudouin Gérard, Manami Shizuka, Michael Louis Miller, Richard A. Silva
  • Methods of preparing cytotoxic benzodiazepine derivatives
    Patent number: 10385071
    Abstract: The invention provides novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.
    Type: Grant
    Filed: January 24, 2018
    Date of Patent: August 20, 2019
    Assignee: IMMUNOGEN, INC.
    Inventors: Baudouin Gérard, Richard A. Silva, Michael Louis Miller, Manami Shizuka