Patents by Inventor Richard A. Tempero

Richard A. Tempero has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for enhancing immune responses mediated by antigen-presenting cells
    Patent number: 7358087
    Abstract: Molecular adjuvants are disclosed comprising an antigen presenting cell-targeting ligand linked to an immunogen. In particular, these molecular adjuvants are employed in compositions designed to deliver the specific immunogen to antigen presenting cells and simultaneously deliver signals to those cells that produce the desired immune response. Methods are also disclosed for delivery of these molecular adjuvants to patients, resulting in the transduction of activating signals to the targeted antigen presenting cell, thereby enhancing the immune response to the co-delivered immunogen.
    Type: Grant
    Filed: September 17, 2001
    Date of Patent: April 15, 2008
    Assignee: Board of Regents of The University of Nebraska
    Inventors: Sam D. Sanderson, Michael A. Hollingsworth, Richard A. Tempero
  • Compositions and methods for enhancing immune responses mediated by antigen-presenting cells
    Publication number: 20070031445
    Abstract: Molecular adjuvants are disclosed comprising an antigen presenting cell-targeting ligand linked to an immunogen, e.g. tumor associated antigens, bacterial or viral antigens. The ligand and the immunogen are linked via a cleavable linker such as a protease-sensitive oligopeptide, to facilitate processing of the adjuvant by the antigen presenting cell. Methods are disclosed for delivery of these molecular adjuvants to patients, resulting in the transduction of activating signals to the targeted antigen presenting cell, thereby enhancing the immune response to the co-delivered immunogen.
    Type: Application
    Filed: June 13, 2006
    Publication date: February 8, 2007
    Inventors: Sam Sanderson, Michael Hollingsworth, Richard Tempero
  • Compositions and methods for enhancing immune responses mediated by antigen-presenting cells
    Patent number: 6821517
    Abstract: Molecular adjuvants are disclosed comprising an antigen presenting cell-targeting ligand functionally linked to an immunogen, e.g. tumor associated antigens, bacterial or viral antigens, etc. Methods are disclosed for delivery of these molecular adjuvants to patients, resulting in the transduction of activating signals to the targeted antigen presenting cell, thereby enhancing the immune response to the co-delivered immunogen.
    Type: Grant
    Filed: April 17, 1998
    Date of Patent: November 23, 2004
    Assignee: The Board of Regents of the University of Nebraska
    Inventors: Sam D. Sanderson, Michael A. Hollingsworth, Richard A. Tempero
  • Compositions and methods for enhancing immune responses mediated by antigen-presenting cells
    Publication number: 20020091234
    Abstract: Molecular adjuvants are disclosed comprising an antigen presenting cell-targeting ligand linked to an immunogen. In particular, these molecular adjuvants are employed in compositions designed to deliver the specific immunogen to antigen presenting cells and simultaneously deliver signals to those cells that produce the desired immune response. Methods are also disclosed for delivery of these molecular adjuvants to patients, resulting in the transduction of activating signals to the targeted antigen presenting cell, thereby enhancing the immune response to the co-delivered immunogen.
    Type: Application
    Filed: September 17, 2001
    Publication date: July 11, 2002
    Applicant: The Board of Regents of the University of Nebraska
    Inventors: Sam D. Sanderson, Michael A. Hollingsworth, Richard A. Tempero