Abstract: The present disclosure relates to a heating system comprising: a heating element for heating a process medium; a DC power converter configured to receive an input direct-current voltage from a power supply and to deliver an output direct-current voltage to the heating element; a sensor arrangement configured to generate a first sensor output signal indicative of a thermodynamic parameter of the process medium or the heating element; and a controller configured to control the DC power converter based on the first sensor output signal.

Abstract: A heat exchanger assembly including an elongated tubular heat exchanger enclosure defining an interior chamber. A tube sheet is positioned within the interior chamber of the heat exchanger enclosure separating the interior chamber into a shell side and a channel side. The interior portion is configured to removably receive a tube bundle positioned within the shell side of the interior chamber. An annular sleeve member is positioned within the channel side of the interior chamber of the heat exchanger enclosure. An annular elastic torsion member is positioned within the channel side of the interior chamber of the heat exchanger such that the sleeve member is positioned between the tube sheet and the elastic torsion member. The elastic torsion member has an inner circumference deflectable relative to its outer circumference for torsioning the elastic torsion member.

Abstract: Systems and methods for drilling a wellbore include delivering electrical energy to a downhole end of the wellbore. A tapered drill string, with larger drill pipes connected in an up-hole portion with a turbine and an electrical generator and a smaller drill pipes coupled in downhole portion may be used to deliver the electrical power. A turbine and generator may be sufficiently sized to harvest the necessary hydraulic energy and safely operated in a subterranean environment. A lower portion system carried by the downhole portion of the drill string is electrically coupled to the generator through the downhole portion of the drill string to utilize the electric power provided by the electrical generator.

Abstract: A predictive model can be applied to data representing a history of events for an entity to compute a value indicative of an outcome related to a reference time for that entity. The effect of an event from an entity's history of events on an outcome for the entity at a reference time can vary based on the type of event and relative time of that event with respect to the reference time. The effect of an event from an entity's history of events on an outcome for the entity also can vary due to other characteristics of the entity in combination with the event. These effects are captured as weights. For an entity, functions of sets of events from the history of events are computed for the entity and a set of weights for events. The computed results are inputs to the predictive model.

Abstract: An apparatus includes an introducer defining an inner volume, a catheter, and a guide member. The having a proximal end portion and a distal end portion, with the catheter defining a lumen extending through the proximal end portion and the distal end portion of the catheter, and with the catheter configured to move between a first position, in which the catheter is disposed within the introducer, and a second position, in which at least the distal end portion of the catheter is distal to the introducer. The guide member is coupled to the introducer, with the guide member defining a lumen. A portion of the catheter is received within the lumen of the guide member when the catheter is in the first position, and the distal end portion of the catheter is distal to the guide member when the catheter is in the second position.

Abstract: The present invention relates to antibodies that specifically bind to one or more of IL-4, IL-13, IL-33, TSLP, and p40. The present invention further relates to antibodies that bind to one of IL-4, IL-13, IL-33, or TSLP. The invention further relates to multispecific antibodies that specifically bind to IL-4 and IL-13, and at least one other target. The present invention relates to multispecific antibodies that bind IL-4, IL-13, and one of IL-33, TSLP, or p40. The present invention also pertains to related molecules, e.g. nucleic acids which encode such antibodies or multispecific antibodies, compositions, and related methods, e.g., methods for producing and purifying such antibodies and multispecific antibodies, and their use in diagnostics and therapeutics.

Abstract: The present disclosure relates to medicament injection devices. An injection device includes: a movable dosage programming component comprising a rotary encoder system having a predefined angular periodicity, a sensor arrangement including a first optical sensor configured to detect movement of the movable dosage programming component relative to the sensor arrangement during dosing of a medicament, wherein the first optical sensor is configured to operate in a strobe-sampling mode at a first frequency, a second optical sensor configured to detect movement of the rotary encoder system relative to the second optical sensor wherein the second optical sensor is configured to operate in a strobe-sampling mode at a second frequency lower than the first frequency, and a processor arrangement configured to, based on the detected movement, determine a medicament dosage administered by the injection device.

Abstract: Devices, systems and methods for controlling a patient's body temperature by endovascular heat exchange.

Abstract: A humidification system can include a heater base, a humidification chamber, and a breathing circuit. A cartridge can be removably coupled to the heater base. The cartridge can include various sensors, probes, sensor wire connectors, heater wire connectors, and/or other features. The cartridge can include features configured to mate with corresponding features on the humidification chamber and the heater base. The cartridge includes a memory, such as an EEPROM, or other suitable storage device. When the cartridge is installed on the heater base, the memory is electrically connected to a processor and/or memory of the heater base. Various models of cartridges can be produced for use with different humidification chambers, breathing circuits, and/or therapies. A connector can be configured to couple an inspiratory conduit to an outlet port of the humidification chamber. The connector can provide a pneumatic connection to the outlet port and an electrical connection to the cartridge.

Abstract: A vacuum cleaner including a vacuum motor configured to draw an air flow through an air flow path of the vacuum cleaner; a dirt separator having dirt, receptacle; a display screen; and a controller configured to control images displayed on the screen. The dirt receptacle has a closed configuration in which it can receive dirt separated from the air flow, and an open configuration in which dirt contained in the dirt receptacle can be emptied therefrom. The controller is configured to display video instructions on the screen.

Abstract: Described herein are neuroactive steroids of the Formula (II): or a pharmaceutically acceptable salt thereof; wherein A, R1, R2a, R2b, R3a, R3b, R4a, R4b, R5, R6 and are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use and treatment, e.g., such for inducing sedation and/or anesthesia.

Abstract: A coupling arrangement for use in an air delivery circuit includes a first connector tube defining a first passage therethrough and a second connector tube defining a second passage therethrough. The second connector tube telescopically receives a portion of the first connector tube within the second passage. A release mechanism includes wedges coupled to the first or second connector tube. The first and second connector tubes have a number of corresponding features that latch the first connector tube within the second passage of the second connector tube when the first connector tube is axially inserted along the longitudinal axis a predetermined distance. Actuation of the wedges radially toward the longitudinal axis causes axial movement among the first connector tube and the second connector tube a second predetermined distance that is sufficient to unlatch the corresponding features.

Abstract: A respiratory interface system for use in delivering a flow of a positive pressure breathing gas to an airway of a patient that includes a patient interface device with a tubing assembly structured to be disposed on the head of the patient, a mask having a sealing element structured to sealingly engage about the airway of the patient, and an adaptor. The adapter includes a flange portion that extends generally radially outward from a central aperture and a hollow male connector extending from the flange portion and coupled with a correspondingly-shaped female connector of the tubing assembly or the mask. The mask is coupled to the tubing assembly via the adaptor, and the tubing assembly, the mask, and the adapter define a pathway structured to conduct the flow of the positive pressure breathing gas to the airway of the patient.

Abstract: Computer-implemented methods, computer-readable storage media storing instructions and computer systems for labeling significant locations based on contextual data can be implemented to perform operations that include determining a location of a computing device, and determining a label for the determined location based on contextual data associated with the significant location. The location can be a significant location that has meaning to a user of the device.

Abstract: An electrochemical cell (3) for use in a fuel cell stack (1) comprising a resilient electrical conduction member sub-assembly (10, 16) having a first flow plate (5, 9), a second flow plate (6, 8) and a bipolar plate (11, 22). A fluid chamber (17, 19) is created by the first flow plate (5, 9), the second flow plate (6, 8), the bipolar plate (11, 22) and an electrode (13, 18) and has an inflow duct (59, 63) and an outflow duct (61, 65). A resilient electrical conduction member (15, 20) is located within the fluid chamber (17, 19) so that in use, a fluid can flow between the inflow duct (59, 61) and the outflow duct (61, 65). The resilient electrical conduction member (15, 20) is in electrically conductive contact with the bipolar plate (11, 22) and with the electrode (13, 18) via a plurality of electrical contacts (51) and the resilient electrical conduction member (15, 20) is compressed between the bipolar plate (11, 22) and the electrode (13, 18).

Abstract: A heat exchanger assembly including an elongated tubular heat exchanger enclosure defining an interior chamber. A tube sheet is positioned within the interior chamber of the heat exchanger enclosure separating the interior chamber into a shell side and a channel side. The interior portion is configured to removably receive a tube bundle positioned within the shell side of the interior chamber. An annular sleeve member is positioned within the channel side of the interior chamber of the heat exchanger enclosure. An annular elastic torsion member is positioned within the channel side of the interior chamber of the heat exchanger such that the sleeve member is positioned between the tube sheet and the elastic torsion member. The elastic torsion member has an inner circumference deflectable relative to its outer circumference for torsioning the elastic torsion member.

Abstract: An air supply arrangement for air flow plates (5) of electrochemical cells (3) within a fuel cell stack (1). Each air flow plate (5) has a gas exchange volume (19). A common air supply pipe (11) supplies air to the air flow plates (5). There is an air supply region (35) and a separate air distribution conduit (15) for each air flow plate (5). Each air distribution conduit (15) provides an air header volume (43) and has an inlet and an outlet. The common air supply pipe (11) is connected to each air supply region (35) and each air supply region (35) is connected to the inlet of each air distribution conduit (15). The outlet of each air distribution conduit (15) is connected to a gas exchange volume (19) and each gas exchange volume (19) extends across the width of the associated air flow plate (5).

Abstract: Disclosed is a method for the treatment of a subject having an HIV infection or inhibiting neddylation using a neddylation inhibiting enzyme, neural-precursor-cell-expressed developmentally down-regulated 8 (NEDD8)-activating enzyme E1 (NAE1).