Abstract: The present invention discloses novel compounds of Formula (I) or pharmaceutically acceptable salts thereof, which have histamine—H3 receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds.

Abstract: A method of operating a communication network comprises receiving loopback addresses from a plurality of edge networks at a provider router of a core backbone network, the edge networks and the core backbone network being logically distinct from each other, advertising the loopback addresses to a transport route reflector element, propagating the advertisement of the loopback addresses to other provider routers of the core backbone network using a protocol for communicating between autonomous systems, and using the transport route reflector element to advertise at least one of the loopback addresses to a service route reflector element in one of the plurality of edge networks.

Abstract: The present invention discloses novel compounds of Formula (I) or pharmaceutically acceptable salts thereof which have histamine-H3 receptor antagonist or inverse agonist activity, as well as methods and intermediates for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of using them to treat obesity, cognitive deficiencies, narcolepsy, and other histamine H3 receptor-related diseases.

Abstract: In one embodiment, a method for drilling a wellbore includes an act of drilling the wellbore by injecting drilling fluid through a tubular string disposed in the wellbore, the tubular string comprising a drill bit disposed on a bottom thereof. The drilling fluid exits the drill bit and carries cuttings from the drill bit. The drilling fluid and cuttings (returns) flow to a surface of the wellbore via an annulus defined by an outer surface of the tubular string and an inner surface of the wellbore. The method further includes an act performed while drilling the wellbore of measuring a first annulus pressure (FAP) using a pressure sensor attached to a casing string hung from a wellhead of the wellbore. The method further includes an act performed while drilling the wellbore of controlling a second annulus pressure (SAP) exerted on a formation exposed to the annulus.

Abstract: An animal control system for use in a plant to facilitate management of the trapping of animals in the plant, the system including: a plurality of animal traps located at discrete locations of the plant, each trap including an animal sensor associated with the trap for detecting an animal trapped in the trap and a transceiver in electronic communication with the animal sensor, the transceiver having an identifier unique to the trap with which it is associated; and a computer system having a plurality of computers in communication with one another for receiving and reporting information relating to conditions of the traps. The discrete locations of the traps are obtained and input into a computer processor for processing to yield a computer generated template of the plant having a template of the plant with the discrete locations of the traps.

Abstract: The present invention discloses novel compounds of Formula I or pharmaceutically acceptable salts thereof which have histamine-H3 receptor antagonist activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I as well as methods of using them to treat obesity and other histamine H3 receptor-related diseases.

Abstract: A backbone network may include first and second border routers and a route reflector. The first border router may provide data connectivity between the backbone network and a first regional network. The first border router may be configured to receive a notification of a change in status of an edge router of the first regional network, and the notification may be received according to a first routing protocol. The first border router may be further configured to redistribute the notification of the change in status of the edge router from the first routing protocol to a second routing protocol with the first and second routing protocols being different. The second border router may provide data connectivity between the backbone network and a second regional network. The route reflector may be coupled between the first and second border routers, and the route reflector may be configured to transfer the redistributed notification from the first border router to the second border router.

Abstract: A dialysis system includes a filtration system capable of filtering a water stream, a water purification system capable of purifying said water stream in a non-batch process, a mixing system capable of producing a stream of dialysate from mixing one or more dialysate components with the water stream in a non-batch process, and a dialyzer system. The dialyzer may be a microfluidic dialyzer capable of being fluidly coupled to the stream of dialysate and a blood stream.

Abstract: The present disclosure concerns embodiments of a microfluidic transfer device. The device mitigates risk of cross contamination between working fluids and is amenable to high-volume, low-cost manufacturing techniques. The device may be configured for mass transfer, heat transfer, or both. For instance, certain disclosed embodiments incorporate semi-permeable membranes to transfer target substances from one fluid to another. Moreover, the device may incorporate both heat and mass transfer components.

Abstract: In one embodiment, a method for drilling a wellbore includes an act of drilling the wellbore by injecting drilling fluid through a tubular string disposed in the wellbore, the tubular string comprising a drill bit disposed on a bottom thereof. The drilling fluid exits the drill bit and carries cuttings from the drill bit. The drilling fluid and cuttings (returns) flow to a surface of the wellbore via an annulus defined by an outer surface of the tubular string and an inner surface of the wellbore. The method further includes an act performed while drilling the wellbore of measuring a first annulus pressure (FAP) using a pressure sensor attached to a casing string hung from a wellhead of the wellbore. The method further includes an act performed while drilling the wellbore of controlling a second annulus pressure (SAP) exerted on a formation exposed to the annulus.

Abstract: A director control interface is provided to extract production information from a newsroom information management system and populate a production control system. The director control interface enables the director to build a show, but mitigate errors and check for conflicts during the building process. In an embodiment, the director control interface automatically selects macro elements, which are executed on the production control system. The director can override the selection process and choose the macro elements. The director control interface monitors the newsroom information management system for rundown changes, evaluates the changes, and updates the production control system either automatically or with approval from the director. The director control interface is compatible with any type of newsroom information management system as long as it can extract the requisite information.

Abstract: Methods and systems for submitting or resubmitting media to a media distribution site are disclosed. The submission or resubmission of media to the media distribution site can be performed by numerous submitters in a uniform and computer-assisted manner. The submitted or resubmitted media can then be processed in a largely automated manner at the media distribution site and then made available for online purchase and distribution.

Abstract: Compounds that are capable of acting as purine receptor antagonists, pharmaceutical compositions including the compounds, and methods of making the compounds, are disclosed. The compounds and compositions can be used in treating or preventing disorders related to purine receptor hyperfunctioning.

Abstract: A backbone network may include first and second border routers and a route reflector. The first border router may provide data connectivity between the backbone network and a first regional network. The first border router may be configured to receive a notification of a change in status of an edge router of the first regional network, and the notification may be received according to a first routing protocol. The first border router may be further configured to redistribute the notification of the change in status of the edge router from the first routing protocol to a second routing protocol with the first and second routing protocols being different. The second border router may provide data connectivity between the backbone network and a second regional network. The route reflector may be coupled between the first and second border routers, and the route reflector may be configured to transfer the redistributed notification from the first border router to the second border router.

Abstract: The present invention discloses novel compounds of Formula (I) or pharmaceutically acceptable salts thereof which have histamine-H3 receptor antagonist or inverse agonist activity, as well as methods and intermediates for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of using these compositions to treat obesity, cognitive deficiencies, narcolepsy, and other histamine H3 receptor-related diseases.

Abstract: The present invention discloses novel compounds of Formula I or pharmaceutically acceptable salts thereof which have histamine-H3 receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I as well as methods of using them to treat obesity, cognitive deficiencies, narcolepsy, and other histamine H3 receptor-related diseases.

Abstract: Polymorphic and solvated forms of solid 3-(4-amino-3-methylbenzyl)-7-(furan-2-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-amine, and methods of making them, are described.

Abstract: A heating element of a printhead has a conductive layer deposited over a substrate, and a resistive layer deposited over and in electrical contact with the conductive layer.

Abstract: The present invention discloses novel compounds of Formula I or pharmaceutically acceptable salts thereof which have histamine-H3 receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I as well as methods of using these compositions to treat obesity, cognitive deficiencies, narcolepsy, and other histamine H3 receptor-related diseases.