Abstract: Epileptic seizures are difficult to diagnose and are often difficult to distinguish from several conditions with similar presentations, and therefore, diagnosis of seizures is often a long, expensive, and unreliable process. This invention provides biomarkers for identifying seizures and epilepsy, assays for measuring and assessing biomarker concentration, predictive models based on biomarkers and computational systems for detecting, assessing and diagnosing phasic and tonic changes associated with seizures and epilepsy in all clinical and healthcare settings. Diagnostic and treatment methods, systems, kits, and predictive models provided herein, provide quantitative and/or qualitative assessment in order to allow patients to proceed immediately to diagnostic and/or treatment protocols, and assess therapeutic treatment effectiveness.

Abstract: A method and apparatus for the indirect measurement of blood pressure is disclosed. Pressure is applied to a cuff attached to a patient adjacent a blood vessel and a quantity representative of the patient's blood pressure is measured as the applied pressure is changed. A first table of values of the quantity as the applied pressure is changed is formed. Values of the first table are selected as spurious high and low values in response to predetermined criteria and new values assigned to the selected values which reduces the error in calculating systolic and diastolic blood pressures from the table. A second table of heart rate values as the applied pressure is changed is formed. Selected heart rate values are set to zero based on predetermined criteria and the locations of the zeros are compared with the locations of systolic, diastolic and maximum values in first table to determine whether to reject or abort the blood pressure reading.