Abstract: An apparatus includes a heat receiving portion which receives heat within a footprint from a heat generating structure, and a cooling arrangement which causes flow of a coolant that absorbs heat at the heat receiving portion, the cooling arrangement being disposed in its entirety within a width of the footprint in a particular direction. A different feature involves an apparatus which includes a heat receiving portion at which a coolant receives heat, and a coolant separating portion which receives coolant traveling away from the heat receiving portion, and which separates liquid coolant from vapor coolant.

Abstract: A method and computer program for evaluating the sustainability of a permanent life insurance policy involves helping a user choose a type of insurance policy that is appropriate by asking the user a series of questions relating to the person's risk and management preferences. A confidence factor is determined for an insurance policy's funding premium, wherein the confidence factor indicates a probability that the policy will sustain until a user-selected age, such as the age of one hundred. The confidence factor is determined by applying parameters of the user's policy to one thousand trial illustrations developed using performance information from actual portfolios over the last forty years, and reporting a percentage of the trial illustrations that sustained through age one hundred. If the confidence factor is unacceptably low, the user adjusts the premium and/or an investment allocation scheme to generate a new confidence factor.

Abstract: The present invention is related to antibodies directed to the antigen PDGFD and uses of such antibodies. In particular, in accordance with the present invention, there are provided fully human monoclonal antibodies directed to the antigen PDGFD. Nucelotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.

Abstract: The present invention is related to antibodies directed to the antigen PDGFD and uses of such antibodies. In particular, in accordance with the present invention, there are provided fully human monoclonal antibodies directed to the antigen PDGFD. Nucelotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.

Abstract: A method of controlling a variable valve actuation system is provided. A cam assembly is operated to move an intake valve between a first position where the intake valve blocks a flow of fluid and a second position where the intake valve allows a flow of fluid. At least one operating parameter of the engine is sensed. A valve actuation period is determined based on the at least one operating parameter. A valve actuator is engaged with the intake valve to prevent the intake valve from returning to the first position in response to operation of the cam assembly. The valve actuator is released to allow the intake valve to return to the first position at the end of the determined valve actuation period.

Abstract: According to one embodiment, an apparatus includes a fluid coolant and structure which reduces a pressure of the fluid coolant through a subambient pressure at which the coolant has a cooling temperature less than a temperature of the heat-generating structure. The apparatus also includes structure that directs a flow of the fluid coolant in the form of a liquid at a subambient pressure in a manner causing the liquid coolant to be brought into thermal communication with the heat-generating structure. The heat from the heat-generating structure causes the liquid coolant to boil and vaporize so that the coolant absorbs heat from the heat-generating structure as the coolant changes state. The structure is configured to circulate the fluid coolant through a flow loop while maintaining the pressure of the fluid coolant within a range having an upper bound less than ambient pressure.

Abstract: An apparatus includes heat-generating structure disposed in an environment having an ambient pressure, and a cooling system for removing heat from the heat-generating structure. The cooling system includes a fluid coolant, structure which reduces a pressure of the coolant to a subambient pressure at which the coolant has a boiling temperature less than a temperature of the heat-generating structure; and structure which directs a flow of the liquid coolant at the subambient pressure so that it is brought into thermal communication with the heat-generating structure, the coolant then absorbing heat and changing to a vapor.

Abstract: In accordance with the present invention, we have discovered that the molecule CD147 as expressed on certain cells, such as T-cells, B-cells, and/or monocytes, can be utilized for the treatment of a variety of diseases. In particular, we have demonstrated that antibodies that bind to CD147 and that result in the killing of such cells, for example, through the binding of complement, is efficacious in the treatment of diseases. Diseases in which such treatment appears efficacious include, without limitation: graft versus host disease (GVHD), organ transplant rejection diseases (including, without limitation, renal transplant, ocular transplant, and others), cancers (including, without limitation, cancers of the blood (i.e., leukemias and lymphomas), pancreatic, and others), autoimmune diseases, inflammatory diseases, and others.

Abstract: According to an embodiment of the present invention, a thermal management system for electronic components includes a plastic coldplate having a mounting surface for mounting one or more electronic components, one or more passageways configured to have a fluid flow therethrough disposed within the plastic coldplate, and a highly conductive material disposed within the plastic coldplate and thermally coupled to the mounting surface. The highly conductive material is operable to transfer heat from the mounting surface to the fluid flow.

Abstract: An accessory system for a vehicle includes an interior rearview mirror assembly and a display screen that is extendable and retractable relative to a casing. The display screen is slidably mounted at the casing and slidable in a direction generally parallel to a length axis of the reflective element between a non-use position, where the video display screen is positioned substantially within the casing, and a use position, where the video display screen is substantially extended from a side of the casing for viewing. The display screen may be automatically extended in response to an activating event. The accessory system may include an accessory module, which may comprise multiple sub-modules that may be selected to provide the desired accessory content to the accessory module.

Abstract: According to one embodiment of the invention a method for controlling cooling of a heat-generating structure disposed in an environment having an ambient pressure includes providing a fluid coolant and reducing the pressure of the coolant to a subambient pressure at which the coolant has a boiling temperature less than a temperature of the heat-generating structure. The method further includes boiling and vaporizing coolant to absorb heat from the heat-generating structure by bringing the coolant into thermal communication with the heat generating structure. The method also includes measuring a parameter indicative of a pressure of the coolant and adjusting the pressure of the coolant in response to control the cooling of the heat-generating structure.

Abstract: According to an embodiment of the present invention, a thermal management system for electronic components includes a plastic coldplate having a mounting surface for mounting one or more electronic components, one or more passageways configured to have a fluid flow therethrough disposed within the plastic coldplate, and a highly conductive material disposed within the plastic coldplate and thermally coupled to the mounting surface. The highly conductive material is operable to transfer heat from the mounting surface to the fluid flow.

Abstract: An apparatus includes a heat receiving portion which receives heat within a footprint from a heat generating structure, and a cooling arrangement which causes flow of a coolant that absorbs heat at the heat receiving portion, the cooling arrangement being disposed in its entirety within a width of the footprint in a particular direction. A different feature involves an apparatus which includes a heat receiving portion at which a coolant receives heat, and a coolant separating portion which receives coolant traveling away from the heat receiving portion, and which separates liquid coolant from vapor coolant.

Abstract: Multi-PHY addressing from source to destination in which n-number of channels or ports are used in a PHY layer device for communication with a link layer device. A single link layer to a single-PHY layer topology and a single link layer to a multi-PHY layer topology comprising multiple ports or channels receives a plurality of channels groups. Status indication signal is provided on continuous basis for the direct status for up to a predetermined number of channels.

Abstract: A method of controlling an engine is provided. At least one operating parameter of the engine is sensed. The engine is operated in a first mode in response to the sensed operating parameter being at one of a predetermined first set of conditions. In the first mode, a cam assembly moves an intake valve from a first position when a piston starts an intake stroke and the cam assembly returns the intake valve to the first position when the piston completes the intake stroke. The engine is operated in a second mode in response to the sensed operating parameter being at one of a predetermined second set of conditions. In the second mode, the cam assembly moves the intake valve from the first position when the piston starts an intake stroke and an actuator prevents the intake valve from returning to the first position in response to the cam assembly.

Abstract: An exterior rearview mirror assembly for a vehicle includes a base portion mounted to the vehicle and a movable portion that is pivotable relative to the base portion via a motor or motorized actuator or powerfold unit or the like. The powerfold unit is operable to pivot the movable portion relative to the base portion. The powerfold unit is mounted at one of the movable portion and the base portion and engages a receiving portion of the other of the movable portion and the base portion. A resilient element is positioned between and at least partially in engagement with the powerfold unit and the receiving portion. The resilient element is resilient and may at least partially compress as the powerfold unit is engaged with the receiving portion, thereby reducing or dampening vibration of the head portion relative to the base portion of the mirror assembly.

Abstract: A heat exchanger extracts heat from a two-phase fluid coolant so that the coolant changes from a vapor state to a liquid state. Two valves have respective inlets which communicate with the coolant in the heat exchanger, and which are physically spaced from each other. Valve control structure responds to the presence of liquid at the inlet to either valve by opening that valve, so that the liquid coolant flows through the valve to a discharge section. A different feature involves a housing with a heat exchanger therein, the heat exchanger having a plurality of coolant conduits that are axially spaced. A flow of air travels axially within the housing, then flows transversely past the conduits to the other side thereof, and then resumes flowing axially on the other side of the conduits.

Abstract: An apparatus includes a heat receiving portion which receives heat within a footprint from a heat generating structure, and a cooling arrangement which causes flow of a coolant that absorbs heat at the heat receiving portion, the cooling arrangement being disposed in its entirety within a width of the footprint in a particular direction. A different feature involves an apparatus which includes a heat receiving portion at which a coolant receives heat, and a coolant separating portion which receives coolant traveling away from the heat receiving portion, and which separates liquid coolant from vapor coolant.

Abstract: A variable universal life insurance product that includes a death benefit and associated investment vehicles is selectively offered. A life insurance policy chassis is provided by an insurance company to an asset manager. The asset manager combines the life insurance policy chassis with one or more associated investment vehicles managed by the asset manager to form a variable universal life insurance product. The asset manager selectively makes the insurance product available to respective clients of the asset manager. The insurance company providing service for the death benefit and the asset manager providing service for the associated investment vehicles.

Abstract: The present invention relates to novel antibodies, particularly antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to the type III deletion mutant, EGFRvIII. The invention also relates to human monoclonal antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to EGFRvIII. Diagnostic and therapeutic formulations of such antibodies, and immunoconjugates thereof, are also provided.