Abstract: The present invention relates to compositions comprising a colloidal dispersion and an Agent of Interest (“AOI”), wherein the colloidal dispersion comprises deformable colloidal particles and wherein the AOI is not associated with the deformable colloidal particles. The present invention also provides kits and transdermal drug release devices comprising the compositions of the present invention, and the use of these compositions in medicine, skin care and cosmetics.

Abstract: Methods and dosage formulations are provided for subcutaneous administration in which therapeutic agents are modified to increase the hydrophilicity and molecular dimensions in relation to the native state of the therapeutic agent, in which the Cmax:Caverage ratio is lower than the Cmax:Caverage ratio of the agent when delivered intravenously.

Abstract: A method of treating a subject includes providing a mobile telecommunications device including a processor, a transceiver coupled to the processor including a transmitter for generating pulsed electrical signals adapted to be coupled to an antenna, at least one memory device accessible by the processor. The mobile telecommunications device is positioned proximate to the subject. Pulsed electrical signals are begun to be generated to cause the transmitter to drive the antenna, wherein the antenna in response to the pulsed electrical signals emits a pulsed electromagnetic field (PEMF) that reaches the subject to provide treatment.

Abstract: The present invention relates to vesicular formulations for use in the treatment of pain and/or reduced mobility associated with a loss of lubrication and/or structural integrity and/or swelling of a collagen structure. It also relates to a method of treating pain such as joint pain or tendonitis comprising topically administering a vesicular formulation according to the invention.

Abstract: A closing device includes an element which can be moved along a path, a drive, an operating element for detecting a closing request, and detector for detecting the position of an ID transmitter paired with the vehicle. The drive is designed to move the movable element along the path, and a closing movement of the movable element is started via the drive if the actuation of an operating element is detected, if an ID transmitter paired with the vehicle is detected in a first position region within a time window t following the actuation of the operating element, and if the ID transmitter paired with the vehicle is not detected in the first position region at least for a duration s, which begins at least within the time window t, after being detected in the first position region within the time window t.

Abstract: The present invention relates to vesicular formulations for use in the topical administration of a therapeutic, metabolic, cosmetic or structural Agent Of Interest (“AOI”) and methods of administering an AOI.

Abstract: A closing device includes an element which can be moved along a path, a drive, an operating element for detecting a closing request, and detector for detecting the position of an ID transmitter paired with the vehicle. The drive is designed to move the movable element along the path, and a closing movement of the movable element is started via the drive if the actuation of an operating element is detected, if an ID transmitter paired with the vehicle is detected in a first position region within a time window t following the actuation of the operating element, and if the ID transmitter paired with the vehicle is not detected in the first position region at least for a duration s, which begins at least within the time window t, after being detected in the first position region within the time window t.

Abstract: A panel-like/sheet-like finishing element (11) for covering floors and walls, for example in the renovation of old buildings, is provided with heat-insulating and sound-absorbing properties if its interior (15) is provided, between outer covering layers (12, 13), with channel-forming undulating supporting structures (16) filled with high-density coarse granules (21). The supporting structures (16) are connected to the covering layers (12, 13) along the vertex lines (17) so as to provide wet-strength action, and the interior (15), between these covering layers, is sealed by enclosing edging strips (19) to provide wet-strength action, with the simultaneous inclusion of moisture-tight, but vapour-permeable, supporting layers (20) on covering layers (12, 13). If this finishing element (11) is mounted vertically, the granule-filled channels (14) run horizontally.

Abstract: The present invention relates to compositions containing vesicular formulations, kits, methods of preparation thereof or uses thereof. The present invention provides improved combinations of formulations, for topical use.

Abstract: The present invention relates to vesicular formulations for use in the topical administration of a biologically active agent, methods of administering a biologically active agent, a combined preparation comprising a vesicular formulation and a kit comprising a vesicular formulation.

Abstract: Methods and dosage formulations are provided for subcutaneous administration in which therapeutic agents are modified to increase the hydrophilicity and molecular dimensions in relation to the native state of the therapeutic agent, in which the Cmax:Caverage ratio is lower than the Cmax:Caverage ratio of the agent when delivered intravenously.

Abstract: The present invention relates to vesicular formulations for use in the treatment of pain and/or reduced mobility associated with a loss of lubrication and/or structural integrity and/or swelling of a collagen structure. It also relates to a method of treating pain such as joint pain or tendonitis comprising topically administering a vesicular formulation according to the invention.

Abstract: A brake pad assembly is provided, including a friction lining providing a wear surface for contacting a brake rotor and a back plate coupled to the friction lining. The back plate is made of a carbon fiber reinforced carbon matrix composite. In one example, a majority of the carbon fibers of the back plate are oriented in a x-y in-plane direction resulting in a structure where the thermal conductivity is at least 2 times greater in the x-y in-plane direction versus a z through-plane direction. In another example, the back plate is provided as at least one sheet of a carbon fiber reinforced carbon matrix composite. A method of manufacturing the brake pad assembly is also provided.

Abstract: In order to automatically actuate a locking element of a vehicle, movement of an object in a region surrounding the vehicle is detected. If the detected movement corresponds to at least one predefined movement profile, the locking element is automatically actuated. If the detected movement does not correspond to the at least one predefined movement profile, a further predefined movement profile is produced depending on the detected movement.

Abstract: A panel-like/sheet-like finishing element (11) for covering floors and walls, for example in the renovation of old buildings, is provided with heat-insulating and sound-absorbing properties if its interior (15) is provided, between outer covering layers (12, 13), with channel-forming undulating supporting structures (16) filled with high-density coarse granules (21). The supporting structures (16) are connected to the covering layers (12, 13) along the vertex lines (17) so as to provide wet-strength action, and the interior (15), between these covering layers, is sealed by enclosing edging strips (19) to provide wet-strength action, with the simultaneous inclusion of moisture-tight, but vapour-permeable, supporting layers (20) on covering layers (12, 13). If this finishing element (11) is mounted vertically, the granule-filled channels (14) run horizontally.

Abstract: A medical instrument in the form of an endoscopic shank instrument includes an actuation element which is axially displaceable in a shank. Two lever arms are pivotably articulated in a manner distanced to one another and are positioned at a proximal side of the shank. The lever arms form part of a grip part. The lever arms are coupled in movement to the actuation element and are coupled directly to one another.

Abstract: An interface device and method for testing a telecommunication circuit by utilizing a test cord that has a first end that is integrated with the interface device and a second end that terminates with a test connector. Upon insertion of the test connector into a test port of a connectivity block, the interface device may be configured to allow for monitoring of the telecommunication circuit, without disrupting the circuit. Similarly, the interface device may be configured to disrupt the telecommunication circuit and allow a user to examine both sides of the circuit.

Abstract: A system and method for delivering digital subscriber line (DSL) service to a subscriber. In a telecommunications network, the signal passing through a protector field is diverted to a cross connect block that can be selectively configured to establish a communication route between the cross connect block and a splitter selectively receiving a DSL signal. The combined signal is then placed back upon the network by the cross connect block, which directs the combined signal back to the protector field.

Abstract: A system and method for delivering digital subscriber line (DSL) service to a subscriber from a remote terminal of a telephone network. Included is a first route for delivering a telephone signal to the subscriber, and a second route for passing the telephone signal through a DSL system before delivering the signal to the subscriber. A disrupter is then used to selectively activate either the first or second route.

Abstract: A brake pad assembly is provided, including a friction lining providing a wear surface for contacting a brake rotor and a back plate coupled to the friction lining. The back plate is made of a carbon fiber reinforced carbon matrix composite. In one example, a majority of the carbon fibers of the back plate are oriented in a x-y in-plane direction resulting in a structure where the thermal conductivity is at least 2 times greater in the x-y in-plane direction versus a z through-plane direction. In another example, the back plate is provided as at least one sheet of a carbon fiber reinforced carbon matrix composite. A method of manufacturing the brake pad assembly is also provided.