Patents by Inventor Richard A. Yost
Richard A. Yost has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11469089Abstract: Atmospheric pressure ion guides are provided. The atmospheric pressure ion guides can include a multi-ring electrode structure connecting a larger opening to a smaller opening and having a series of ring electrodes with decreasing diameter and voltage going from the larger opening to the smaller opening. The electrodes can be made from stainless steel or other suitable conductive material. The multi-ring electrode structure can be contained in a housing, such as a housing made from polyetheretherketone or other suitable thermosetting polymer. The atmospheric pressure ion guide can focus ions from an ion source for use with ion detection devices such as an ion mobility spectrometer or a mass spectrometer. Methods of using the atmospheric pressure ion guides are provided, for example to focus a plurality of ions to be injected into an ion detection device. The atmospheric pressure ion guides can increase the signal intensity of the ion detection device.Type: GrantFiled: February 17, 2020Date of Patent: October 11, 2022Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATEDInventors: Jared J. Boock, Joaquin Jesus Casanova, Richard A. Yost, Brian Smith
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Publication number: 20220037139Abstract: An IROA Matrix of metabolite compounds is disclosed. Each of whose compounds has a molecular weight of 2000 AMU or less, and is present as first and second isotopomers that are equally present at two predetermined isotopomeric balances, and contain 2 to 10% of a first isotope, and 90 to 98% of a second isotope, respectively. A reagent pair for transforming a natural abundance mass spectral analysis metabolite sample into an IROA sample is also disclosed and comprises two reactively identical reagents that constitute first and second isotopomers containing 2 to 10% of a first isotope, and 90 to 98% of a second isotope, respectively. Each of the reagent pair contains the same reactive group that reacts with and bonds to a functional group of one or more compounds present in a composition of biologically-produced metabolite compounds. Methods of making and using the above and related materials are also disclosed.Type: ApplicationFiled: May 14, 2021Publication date: February 3, 2022Applicant: IROA Technologies, LLCInventors: Christopher Beecher, Richard A. Yost, Robin Hendrikus Johannes Kemperman
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Publication number: 20200258732Abstract: Atmospheric pressure ion guides are provided. The atmospheric pressure ion guides can include a multi-ring electrode structure connecting a larger opening to a smaller opening and having a series of ring electrodes with decreasing diameter and voltage going from the larger opening to the smaller opening. The electrodes can be made from stainless steel or other suitable conductive material. The multi-ring electrode structure can be contained in a housing, such as a housing made from polyetheretherketone or other suitable thermosetting polymer. The atmospheric pressure ion guide can focus ions from an ion source for use with ion detection devices such as an ion mobility spectrometer or a mass spectrometer. Methods of using the atmospheric pressure ion guides are provided, for example to focus a plurality of ions to be injected into an ion detection device. The atmospheric pressure ion guides can increase the signal intensity of the ion detection device.Type: ApplicationFiled: February 17, 2020Publication date: August 13, 2020Inventors: Jared J. Boock, Joaquin Jesus Casanova, Richard A. Yost, Brian Smith
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Patent number: 10607826Abstract: Atmospheric pressure ion guides are provided. The atmospheric pressure ion guides can include a multi-ring electrode structure connecting a larger opening to a smaller opening and having a series of ring electrodes with decreasing diameter and voltage going from the larger opening to the smaller opening. The electrodes can be made from stainless steel or other suitable conductive material. The multi-ring electrode structure can be contained in a housing, such as a housing made from polyetheretherketone or other suitable thermosetting polymer. The atmospheric pressure ion guide can focus ions from an ion source for use with ion detection devices such as an ion mobility spectrometer or a mass spectrometer. Methods of using the atmospheric pressure ion guides are provided, for example to focus a plurality of ions to be injected into an ion detection device. The atmospheric pressure ion guides can increase the signal intensity of the ion detection device.Type: GrantFiled: July 28, 2016Date of Patent: March 31, 2020Assignee: University of Florida Research Foundation, IncorporatedInventors: Jared J. Boock, Joaquin Jesus Casanova, Richard A. Yost, Brian Smith
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Publication number: 20190307396Abstract: A system for collecting cannabis and the psychoactive component tetrahydrocannabinol or other controlled substances from a sample of exhaled breath. Single or multiple exhaled breaths are conditioned by removing contaminants, and regulating flow rate and/or pressure to collect a sample of tetrahydrocannabinol for timely local or remote analysis using FAIMS. The cannabis detection system comprises a containment trap for removing interfering materials from the breath of the subject and a collection component for sampling components of breath introduced into the system through the containment trap for FAIMS analysis to determine the level of THC or other controlled substance in the breath.Type: ApplicationFiled: March 6, 2017Publication date: October 10, 2019Inventors: Rajpaul ATTARIWALA, Kulwant MALHI, Richard YOST, Jared BOOCK, Michael T. COSTANZO
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Publication number: 20180315587Abstract: An IROA Matrix of metabolite compounds is disclosed. Each of whose compounds has a molecular weight of 2000 AMU or less, and is present as first and second isotopomers that are equally present at two predetermined isotopomeric balances, and contain 2 to 10% of a first isotope, and 90 to 98% of a second isotope, respectively. A reagent pair for transforming a natural abundance mass spectral analysis metabolite sample into an IROA sample is also disclosed and comprises two reactively identical reagents that constitute first and second isotopomers containing 2 to 10% of a first isotope, and 90 to 98% of a second isotope, respectively. Each of the reagent pair contains the same reactive group that reacts with and bonds to a functional group of one or more compounds present in a composition of biologically-produced metabolite compounds. Methods of making and using the above and related materials are also disclosed.Type: ApplicationFiled: February 26, 2018Publication date: November 1, 2018Inventors: Christopher Beecher, Richard A. Yost, Robin Hendrikus Johannes Kemperman
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Publication number: 20180233342Abstract: Atmospheric pressure ion guides are provided. The atmospheric pressure ion guides can include a multi-ring electrode structure connecting a larger opening to a smaller opening and having a series of ring electrodes with decreasing diameter and voltage going from the larger opening to the smaller opening. The electrodes can be made from stainless steel or other suitable conductive material. The multi-ring electrode structure can be contained in a housing, such as a housing made from polyetheretherketone or other suitable thermosetting polymer. The atmospheric pressure ion guide can focus ions from an ion source for use with ion detection devices such as an ion mobility spectrometer or a mass spectrometer. Methods of using the atmospheric pressure ion guides are provided, for example to focus a plurality of ions to be injected into an ion detection device. The atmospheric pressure ion guides can increase the signal intensity of the ion detection device.Type: ApplicationFiled: July 28, 2016Publication date: August 16, 2018Inventors: JARED J. BOOCK, JOAQUIN JESUS CASANOVA, RICHARD A. YOST, BRIAN SMITH
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Publication number: 20120196297Abstract: The present invention is a method for the characterization or detection of one or more antibodies in a sample. The method comprises obtaining a tagged antigen comprising an antigen and a mass tag attached to the antigen. The tagged antigen has specificity for the antibody. In addition, the method comprises combining the tagged antigen with the antibody to form a tagged antigen-antibody complex. Further, the method comprises cleaving the mass tag from the tagged antigen-antibody complex. Thereafter, the method comprises analyzing the mass tag via a mass spectrometer to determine the presence of the mass tag in the sample and correlating the presence of the mass tag with a presence of the antibody in the sample.Type: ApplicationFiled: July 14, 2010Publication date: August 2, 2012Inventor: Richard A. Yost
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Patent number: 7771713Abstract: Compositions and methods employing the compositions for attracting arthropods. The compositions comprise at least one compound of formula I and at least one compound from group II.Type: GrantFiled: September 26, 2003Date of Patent: August 10, 2010Inventors: Ulrich Bernier, Donald Barnard, Matthew Booth, Daniel Kline, Kenneth Posey, Richard Yost
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Publication number: 20070288172Abstract: Among other things, configuring an information collection/retrieval system includes receiving a data file structured to describe biological data, generating a first metadata representation of a first part of the data file, generating a first configuration file based on the first metadata representation; and configuring the information collection/retrieval system using the first configuration file.Type: ApplicationFiled: June 9, 2006Publication date: December 13, 2007Inventors: David Benjamin Aronow, Mark Richard Cacciapouti, Gregg Richard Yost, Bonnie Lynne Zeigler
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Patent number: 7135674Abstract: A method of separating ions comprises applying a spot of a sample material to a target plate. The target plate is mounted in fluid communication with an ion inlet orifice of a FAIMS analyzer region and externally to the FAIMS analyzer region. Using a laser light source that is disposed external to the FAIMS analyzer region, the target plate is irradiated with light of a predetermined wavelength, the light of a predetermined wavelength being selected to affect the sample material applied to the target plate so as to produce ions of the sample material. The ions of the sample material are directed along an ion flow path between the target plate and FAIMS analyzer region, via the ion inlet orifice. A flow of a gas is directed counter-current to the ion flow path and passing through the target plate. The flow of gas through the target plate assists in desolvation of ions and directs neutral molecules away from the FAIMS analyzer region.Type: GrantFiled: January 21, 2005Date of Patent: November 14, 2006Assignees: Thermo Finnigan LLC, University of FloridaInventors: Roger Guevremont, Ragnar Dworschak, Richard A. Yost, Christopher Karl Hilton, Michael William Belford
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Publication number: 20050161597Abstract: A method of separating ions comprises applying a spot of a sample material to a target plate. The target plate is mounted in fluid communication with an ion inlet orifice of a FAIMS analyzer region and externally to the FAIMS analyzer region. Using a laser light source that is disposed external to the FAIMS analyzer region, the target plate is irradiated with light of a predetermined wavelength, the light of a predetermined wavelength being selected to affect the sample material applied to the target plate so as to produce ions of the sample material. The ions of the sample material are directed along an ion flow path between the target plate and FAIMS analyzer region, via the ion inlet orifice. A flow of a gas is directed counter-current to the ion flow path and passing through the target plate. The flow of gas through the target plate assists in desolvation of ions and directs neutral molecules away from the FAIMS analyzer region.Type: ApplicationFiled: January 21, 2005Publication date: July 28, 2005Applicants: Ionalytics Corporation, University of FloridaInventors: Roger Guevremont, Ragnar Dworschak, Richard Yost, Christopher Hilton, Michael Belford
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Publication number: 20050118223Abstract: Compositions and methods employing the compositions for attracting arthropods. The compositions comprise at least one compound of formula I and at least one compound from group II.Type: ApplicationFiled: September 26, 2003Publication date: June 2, 2005Inventors: Ulrich Bernier, Donald Barnard, Matthew Booth, Daniel Kline, Kenneth Posey, Richard Yost
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Patent number: 6800279Abstract: Compositions and methods employing the compositions for attracting arthropods. The compositions comprise at least one compound of formula I and at least one compound from group II.Type: GrantFiled: May 4, 2001Date of Patent: October 5, 2004Assignees: The United States of America as represented by the Secretary of the Agriculture, University of FloridaInventors: Ulrich R. Bernier, Donald R. Barnard, Matthew M. Booth, Daniel L. Kline, Kenneth H. Posey, Richard A. Yost
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Publication number: 20020028191Abstract: Compositions and methods employing the compositions for attracting arthropods. The compositions comprise at least one compound of formula I and at least one compound from group II.Type: ApplicationFiled: May 4, 2001Publication date: March 7, 2002Inventors: Ulrich R. Bernier, Donald R. Barnard, Matthew M. Booth, Daniel L. Kline, Kenneth H. Posey, Richard A. Yost
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Patent number: 6267953Abstract: Compositions and methods employing the compositions for attracting arthropods. The compositions comprise at least one compound of formula I and at least one compound from group II.Type: GrantFiled: May 4, 1999Date of Patent: July 31, 2001Assignee: The United States of America as represented by the Secretary of AgricultureInventors: Ulrich R. Bernier, Daniel L. Kline, Donald R. Barnard, Kenneth H. Posey, Matthew M. Booth, Richard A. Yost
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Patent number: 6147348Abstract: The subject invention pertains to a scan function which will allow parent and neutral loss scans, with a reduced number of false positives, greater detection efficiency, shortened time periods, and enhanced mass resolution, to be performed on the quadrupole ion trap mass spectrometer. In a specific embodiment, the subject invention involves first trapping ions of interest and obtaining a mass spectrum of the m/z range of interest. The (m/z)'s which are present and meet certain predetermined criteria can then be selected and stored. Ions are again trapped in the ion trap and then all ions with (m/z)'s below that of the first ion of interest are ejected. The first ion of interest is resonantly excited to cause CID and the presence of a particular daughter ion is then determined using a standard mass-selective instability scan over a narrow m/z range with resonant ejection at a predetermined ejection q.sub.z.Type: GrantFiled: May 17, 1999Date of Patent: November 14, 2000Assignee: University of FloridaInventors: Scott T. Quarmby, Richard A. Yost
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Patent number: 5747801Abstract: The methods and devices which improve the trapping efficiency of injected ions for quadrupole ion traps. The methods and apparatus of the subject invention can be used in quadrupole ion trap mass spectrometry. The technique of the subject can, for example, vary the amplitude of the trap offset voltage with respect to RF phase angle and/or apply a time varying voltage to at least one lens external to the trap, thus altering the potential energy profile near the entrance to the trap and, therefore, altering the kinetic energy and/or arrival time of ions entering the ion trap. By controlling the kinetic energy and/or arrival time, a larger percentage of injected ions arrive at the ion trap with a kinetic energy conducive for trapping given the corresponding arrival RF phase angle. This allows a larger percentage of injected ions to be successfully trapped and therefore improves the sensitivity and analytical utility of the mass spectrometer.Type: GrantFiled: January 24, 1997Date of Patent: May 5, 1998Assignee: University of FloridaInventors: Scott T. Quarmby, Richard A. Yost
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Patent number: 5352890Abstract: There is described a method of operating an ion trap mass spectrometer. The method is carried out by trapping ions of selected masses in a three-dimensional field and then generating at least two fields in said trap having different frequencies to excite multiple trapped ions.Type: GrantFiled: December 14, 1992Date of Patent: October 4, 1994Assignees: University of Florida, Finnigan CorporationInventors: Jodie V. Johnson, Randall E. Pedder, Richard A. Yost, Michael S. Story
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Patent number: 5171991Abstract: Disclosed is quadrupole ion trap mass spectrometer of the type including a ring electrode and end caps defining a trap volume and including means for introducing sample ion into the ion trap and means for applying voltages to the electrodes. Further included are means for applying two resonant excitation waveforms at two different frequencies and two different voltages between the end cap electrodes to simultaneously excite multiple ions in the ion trap volume.Type: GrantFiled: January 25, 1991Date of Patent: December 15, 1992Assignee: Finnigan CorporationInventors: Jodie V. Johnson, Randall E. Pedder, Richard A. Yost, Michael S. Story