Patents by Inventor Richard A. Yost

Richard A. Yost has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200258732
    Abstract: Atmospheric pressure ion guides are provided. The atmospheric pressure ion guides can include a multi-ring electrode structure connecting a larger opening to a smaller opening and having a series of ring electrodes with decreasing diameter and voltage going from the larger opening to the smaller opening. The electrodes can be made from stainless steel or other suitable conductive material. The multi-ring electrode structure can be contained in a housing, such as a housing made from polyetheretherketone or other suitable thermosetting polymer. The atmospheric pressure ion guide can focus ions from an ion source for use with ion detection devices such as an ion mobility spectrometer or a mass spectrometer. Methods of using the atmospheric pressure ion guides are provided, for example to focus a plurality of ions to be injected into an ion detection device. The atmospheric pressure ion guides can increase the signal intensity of the ion detection device.
    Type: Application
    Filed: February 17, 2020
    Publication date: August 13, 2020
    Inventors: Jared J. Boock, Joaquin Jesus Casanova, Richard A. Yost, Brian Smith
  • Patent number: 10607826
    Abstract: Atmospheric pressure ion guides are provided. The atmospheric pressure ion guides can include a multi-ring electrode structure connecting a larger opening to a smaller opening and having a series of ring electrodes with decreasing diameter and voltage going from the larger opening to the smaller opening. The electrodes can be made from stainless steel or other suitable conductive material. The multi-ring electrode structure can be contained in a housing, such as a housing made from polyetheretherketone or other suitable thermosetting polymer. The atmospheric pressure ion guide can focus ions from an ion source for use with ion detection devices such as an ion mobility spectrometer or a mass spectrometer. Methods of using the atmospheric pressure ion guides are provided, for example to focus a plurality of ions to be injected into an ion detection device. The atmospheric pressure ion guides can increase the signal intensity of the ion detection device.
    Type: Grant
    Filed: July 28, 2016
    Date of Patent: March 31, 2020
    Assignee: University of Florida Research Foundation, Incorporated
    Inventors: Jared J. Boock, Joaquin Jesus Casanova, Richard A. Yost, Brian Smith
  • Publication number: 20190307396
    Abstract: A system for collecting cannabis and the psychoactive component tetrahydrocannabinol or other controlled substances from a sample of exhaled breath. Single or multiple exhaled breaths are conditioned by removing contaminants, and regulating flow rate and/or pressure to collect a sample of tetrahydrocannabinol for timely local or remote analysis using FAIMS. The cannabis detection system comprises a containment trap for removing interfering materials from the breath of the subject and a collection component for sampling components of breath introduced into the system through the containment trap for FAIMS analysis to determine the level of THC or other controlled substance in the breath.
    Type: Application
    Filed: March 6, 2017
    Publication date: October 10, 2019
    Inventors: Rajpaul ATTARIWALA, Kulwant MALHI, Richard YOST, Jared BOOCK, Michael T. COSTANZO
  • Publication number: 20180315587
    Abstract: An IROA Matrix of metabolite compounds is disclosed. Each of whose compounds has a molecular weight of 2000 AMU or less, and is present as first and second isotopomers that are equally present at two predetermined isotopomeric balances, and contain 2 to 10% of a first isotope, and 90 to 98% of a second isotope, respectively. A reagent pair for transforming a natural abundance mass spectral analysis metabolite sample into an IROA sample is also disclosed and comprises two reactively identical reagents that constitute first and second isotopomers containing 2 to 10% of a first isotope, and 90 to 98% of a second isotope, respectively. Each of the reagent pair contains the same reactive group that reacts with and bonds to a functional group of one or more compounds present in a composition of biologically-produced metabolite compounds. Methods of making and using the above and related materials are also disclosed.
    Type: Application
    Filed: February 26, 2018
    Publication date: November 1, 2018
    Inventors: Christopher Beecher, Richard A. Yost, Robin Hendrikus Johannes Kemperman
  • Publication number: 20180233342
    Abstract: Atmospheric pressure ion guides are provided. The atmospheric pressure ion guides can include a multi-ring electrode structure connecting a larger opening to a smaller opening and having a series of ring electrodes with decreasing diameter and voltage going from the larger opening to the smaller opening. The electrodes can be made from stainless steel or other suitable conductive material. The multi-ring electrode structure can be contained in a housing, such as a housing made from polyetheretherketone or other suitable thermosetting polymer. The atmospheric pressure ion guide can focus ions from an ion source for use with ion detection devices such as an ion mobility spectrometer or a mass spectrometer. Methods of using the atmospheric pressure ion guides are provided, for example to focus a plurality of ions to be injected into an ion detection device. The atmospheric pressure ion guides can increase the signal intensity of the ion detection device.
    Type: Application
    Filed: July 28, 2016
    Publication date: August 16, 2018
    Inventors: JARED J. BOOCK, JOAQUIN JESUS CASANOVA, RICHARD A. YOST, BRIAN SMITH
  • Publication number: 20120196297
    Abstract: The present invention is a method for the characterization or detection of one or more antibodies in a sample. The method comprises obtaining a tagged antigen comprising an antigen and a mass tag attached to the antigen. The tagged antigen has specificity for the antibody. In addition, the method comprises combining the tagged antigen with the antibody to form a tagged antigen-antibody complex. Further, the method comprises cleaving the mass tag from the tagged antigen-antibody complex. Thereafter, the method comprises analyzing the mass tag via a mass spectrometer to determine the presence of the mass tag in the sample and correlating the presence of the mass tag with a presence of the antibody in the sample.
    Type: Application
    Filed: July 14, 2010
    Publication date: August 2, 2012
    Inventor: Richard A. Yost
  • Patent number: 7771713
    Abstract: Compositions and methods employing the compositions for attracting arthropods. The compositions comprise at least one compound of formula I and at least one compound from group II.
    Type: Grant
    Filed: September 26, 2003
    Date of Patent: August 10, 2010
    Inventors: Ulrich Bernier, Donald Barnard, Matthew Booth, Daniel Kline, Kenneth Posey, Richard Yost
  • Publication number: 20070288172
    Abstract: Among other things, configuring an information collection/retrieval system includes receiving a data file structured to describe biological data, generating a first metadata representation of a first part of the data file, generating a first configuration file based on the first metadata representation; and configuring the information collection/retrieval system using the first configuration file.
    Type: Application
    Filed: June 9, 2006
    Publication date: December 13, 2007
    Inventors: David Benjamin Aronow, Mark Richard Cacciapouti, Gregg Richard Yost, Bonnie Lynne Zeigler
  • Patent number: 7135674
    Abstract: A method of separating ions comprises applying a spot of a sample material to a target plate. The target plate is mounted in fluid communication with an ion inlet orifice of a FAIMS analyzer region and externally to the FAIMS analyzer region. Using a laser light source that is disposed external to the FAIMS analyzer region, the target plate is irradiated with light of a predetermined wavelength, the light of a predetermined wavelength being selected to affect the sample material applied to the target plate so as to produce ions of the sample material. The ions of the sample material are directed along an ion flow path between the target plate and FAIMS analyzer region, via the ion inlet orifice. A flow of a gas is directed counter-current to the ion flow path and passing through the target plate. The flow of gas through the target plate assists in desolvation of ions and directs neutral molecules away from the FAIMS analyzer region.
    Type: Grant
    Filed: January 21, 2005
    Date of Patent: November 14, 2006
    Assignees: Thermo Finnigan LLC, University of Florida
    Inventors: Roger Guevremont, Ragnar Dworschak, Richard A. Yost, Christopher Karl Hilton, Michael William Belford
  • Publication number: 20050161597
    Abstract: A method of separating ions comprises applying a spot of a sample material to a target plate. The target plate is mounted in fluid communication with an ion inlet orifice of a FAIMS analyzer region and externally to the FAIMS analyzer region. Using a laser light source that is disposed external to the FAIMS analyzer region, the target plate is irradiated with light of a predetermined wavelength, the light of a predetermined wavelength being selected to affect the sample material applied to the target plate so as to produce ions of the sample material. The ions of the sample material are directed along an ion flow path between the target plate and FAIMS analyzer region, via the ion inlet orifice. A flow of a gas is directed counter-current to the ion flow path and passing through the target plate. The flow of gas through the target plate assists in desolvation of ions and directs neutral molecules away from the FAIMS analyzer region.
    Type: Application
    Filed: January 21, 2005
    Publication date: July 28, 2005
    Applicants: Ionalytics Corporation, University of Florida
    Inventors: Roger Guevremont, Ragnar Dworschak, Richard Yost, Christopher Hilton, Michael Belford
  • Publication number: 20050118223
    Abstract: Compositions and methods employing the compositions for attracting arthropods. The compositions comprise at least one compound of formula I and at least one compound from group II.
    Type: Application
    Filed: September 26, 2003
    Publication date: June 2, 2005
    Inventors: Ulrich Bernier, Donald Barnard, Matthew Booth, Daniel Kline, Kenneth Posey, Richard Yost
  • Patent number: 6800279
    Abstract: Compositions and methods employing the compositions for attracting arthropods. The compositions comprise at least one compound of formula I and at least one compound from group II.
    Type: Grant
    Filed: May 4, 2001
    Date of Patent: October 5, 2004
    Assignees: The United States of America as represented by the Secretary of the Agriculture, University of Florida
    Inventors: Ulrich R. Bernier, Donald R. Barnard, Matthew M. Booth, Daniel L. Kline, Kenneth H. Posey, Richard A. Yost
  • Publication number: 20020028191
    Abstract: Compositions and methods employing the compositions for attracting arthropods. The compositions comprise at least one compound of formula I and at least one compound from group II.
    Type: Application
    Filed: May 4, 2001
    Publication date: March 7, 2002
    Inventors: Ulrich R. Bernier, Donald R. Barnard, Matthew M. Booth, Daniel L. Kline, Kenneth H. Posey, Richard A. Yost
  • Patent number: 6267953
    Abstract: Compositions and methods employing the compositions for attracting arthropods. The compositions comprise at least one compound of formula I and at least one compound from group II.
    Type: Grant
    Filed: May 4, 1999
    Date of Patent: July 31, 2001
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventors: Ulrich R. Bernier, Daniel L. Kline, Donald R. Barnard, Kenneth H. Posey, Matthew M. Booth, Richard A. Yost
  • Patent number: 6147348
    Abstract: The subject invention pertains to a scan function which will allow parent and neutral loss scans, with a reduced number of false positives, greater detection efficiency, shortened time periods, and enhanced mass resolution, to be performed on the quadrupole ion trap mass spectrometer. In a specific embodiment, the subject invention involves first trapping ions of interest and obtaining a mass spectrum of the m/z range of interest. The (m/z)'s which are present and meet certain predetermined criteria can then be selected and stored. Ions are again trapped in the ion trap and then all ions with (m/z)'s below that of the first ion of interest are ejected. The first ion of interest is resonantly excited to cause CID and the presence of a particular daughter ion is then determined using a standard mass-selective instability scan over a narrow m/z range with resonant ejection at a predetermined ejection q.sub.z.
    Type: Grant
    Filed: May 17, 1999
    Date of Patent: November 14, 2000
    Assignee: University of Florida
    Inventors: Scott T. Quarmby, Richard A. Yost
  • Patent number: 5747801
    Abstract: The methods and devices which improve the trapping efficiency of injected ions for quadrupole ion traps. The methods and apparatus of the subject invention can be used in quadrupole ion trap mass spectrometry. The technique of the subject can, for example, vary the amplitude of the trap offset voltage with respect to RF phase angle and/or apply a time varying voltage to at least one lens external to the trap, thus altering the potential energy profile near the entrance to the trap and, therefore, altering the kinetic energy and/or arrival time of ions entering the ion trap. By controlling the kinetic energy and/or arrival time, a larger percentage of injected ions arrive at the ion trap with a kinetic energy conducive for trapping given the corresponding arrival RF phase angle. This allows a larger percentage of injected ions to be successfully trapped and therefore improves the sensitivity and analytical utility of the mass spectrometer.
    Type: Grant
    Filed: January 24, 1997
    Date of Patent: May 5, 1998
    Assignee: University of Florida
    Inventors: Scott T. Quarmby, Richard A. Yost
  • Patent number: 5352890
    Abstract: There is described a method of operating an ion trap mass spectrometer. The method is carried out by trapping ions of selected masses in a three-dimensional field and then generating at least two fields in said trap having different frequencies to excite multiple trapped ions.
    Type: Grant
    Filed: December 14, 1992
    Date of Patent: October 4, 1994
    Assignees: University of Florida, Finnigan Corporation
    Inventors: Jodie V. Johnson, Randall E. Pedder, Richard A. Yost, Michael S. Story
  • Patent number: 5171991
    Abstract: Disclosed is quadrupole ion trap mass spectrometer of the type including a ring electrode and end caps defining a trap volume and including means for introducing sample ion into the ion trap and means for applying voltages to the electrodes. Further included are means for applying two resonant excitation waveforms at two different frequencies and two different voltages between the end cap electrodes to simultaneously excite multiple ions in the ion trap volume.
    Type: Grant
    Filed: January 25, 1991
    Date of Patent: December 15, 1992
    Assignee: Finnigan Corporation
    Inventors: Jodie V. Johnson, Randall E. Pedder, Richard A. Yost, Michael S. Story
  • Patent number: 5128542
    Abstract: This invention relates generally to a method of operating an ion trap mass spectrometer to determine the resonant excitation frequencies of trapped ions. This can be achieved by: (1) introducing sample ions into the ion trap volume: (2) adjusting the trapping fields so that parent ions having a mass-to-charge ratio of interest which are to undergo collision induced dissociation (CID) are trapped; (3) applying an excitation voltage of predetermined frequency and amplitude across the end caps of the ion trap; (4) scanning the frequency of the excitation voltage in a first direction and monitoring for ejection of the parent ions; (5) repeating steps (1) through (3) and scanning the frequency of the excitation voltage in an opposite direction and monitoring for ejection of the parent ions; (6) averaging the frequencies at which the ions are ejected; and (7) applying that frequency in a subsequent MS/MS scan to promote CID of the parent ions to form daughter ions.
    Type: Grant
    Filed: January 25, 1991
    Date of Patent: July 7, 1992
    Assignee: Finnigan Corporation
    Inventors: Nathan A. Yates, Stephen C. Bradshaw, Richard A. Yost, David B. Tucker
  • Patent number: 5114439
    Abstract: An improved system and method for high resolution gas chromatography (GC) is disclosed. This invention involves the use of fused silica open tubular capillary columns having a conductive exterior coating and an arrangement for electrically coupling a power source to such coating, whereby it is now possible to effect direct resistive heating of the capillary column while controlling the temperature thereof. Such control is achieved by measurement of the resistance of the conductive coating, correlating such resistance with the temperature of the column and increasing or decreasing the electrical power supplied to such coating, as appropriate, to effect the desired adjustment in column temperature. Because of the low thermal mass of the column and the conductive coating, temperature changes can be effected readily thereby improving the speed of such separation and reducing the time interval between resolution of successive samples.
    Type: Grant
    Filed: September 25, 1990
    Date of Patent: May 19, 1992
    Assignee: University of Florida
    Inventors: Richard A. Yost, Mark E. Hail