Patents by Inventor Richard A. Zager

Richard A. Zager has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL TETRAHYDROCURCUMIN COMPOSITIONS, METHODS OF MAKING, AND METHODS OF USING THE SAME
    Publication number: 20200281871
    Abstract: The present invention relates to novel tetrahydrocurcumin (THCu) compositions, novel methods of manufacturing, and methods of using these compositions for therapeutic applications. The novel synthetic pathway(s) result in THCu compositions that generally lack hexahydrocurcumin (HHC), and include an improved impurity profile with reduced additional species that are generally present in hydrogenated curcumin compositions.
    Type: Application
    Filed: March 6, 2020
    Publication date: September 10, 2020
    Inventors: Donald Jeffrey KEYSER, Alvaro F. GUILLEM, Bhupinder SINGH, Richard A. ZAGER
  • NOVEL IRON COMPOSITIONS AND METHODS OF MAKING AND USING THE SAME
    Publication number: 20200277325
    Abstract: The present invention involves a novel aqueous iron composition. The aqueous iron composition includes iron sucrose and bicarbonate. The aqueous iron composition of the invention exhibits enhanced renal protective effects relative to conventional iron sucrose compositions.
    Type: Application
    Filed: February 28, 2020
    Publication date: September 3, 2020
    Inventors: Donald Jeffrey KEYSER, Alvaro F. GUILLEM, Richard A. ZAGER
  • METHODS FOR TREATING RENAL INJURY BY THERAPEUTICALLY UPREGULATING P21
    Publication number: 20200171051
    Abstract: The present invention relates to methods for treating acute kidney injury that utilize a glucocorticoid prodrug. The glucocorticoid prodrug selectively delivers a glucocorticoid to the kidney, where it is capable of eliciting a p21 protective response. The present invention also contemplates several novel glucocorticoid prodrugs capable of use in the above manner.
    Type: Application
    Filed: November 27, 2019
    Publication date: June 4, 2020
    Inventors: Richard A. ZAGER, Donald Jeffrey KEYSER, Alvaro F. GUILLEM
  • Compositions, kits, and methods to induce acquired cytoresistance using stress protein inducers
    Patent number: 10639321
    Abstract: The present disclosure provides compositions, kits, and methods to protect organs by inducing acquired cytoresistance without causing injury to the organ. The compositions, kits, and methods utilize heme proteins, iron and/or vitamin B12 and, optionally, agents that impact heme protein metabolism.
    Type: Grant
    Filed: September 28, 2015
    Date of Patent: May 5, 2020
    Assignee: FRED HUTCHINSON CANCER RESEARCH CENTER
    Inventors: Richard Zager, Ali C M Johnson
  • METHODS OF TREATING PATIENTS AT RISK FOR RENAL INJURY AND RENAL FAILURE
    Publication number: 20200057076
    Abstract: The p21 biomarker is utilized in the evaluation of whether a patient is suffering from kidney injury or failure, and can be used in methods of treating kidney injury or failure by determining the appropriateness of one or more of initiating renal replacement therapy, withdrawing delivery of compounds that are known to be damaging to the kidney, delaying or avoiding procedures that are known to be damaging to the kidney, and modifying diuretic administration.
    Type: Application
    Filed: May 24, 2019
    Publication date: February 20, 2020
    Inventors: Richard A. ZAGER, Donald Jeffrey KEYSER, Alvaro F. GUILLEM
  • COMPOSITIONS, KITS, AND METHODS TO INDUCE ACQUIRED CYTORESISTANCE USING STRESS PROTEIN INDUCERS
    Publication number: 20190358242
    Abstract: The present disclosure provides compositions, kits, and methods to protect organs by inducing acquired cytoresistance without causing injury to the organ. The compositions, kits, and methods utilize Me-porphryin complexs, heme proteins, iron containing molecules, and/or vitamin B12 and, optionally, agents that impact heme protein metabolism.
    Type: Application
    Filed: February 6, 2018
    Publication date: November 28, 2019
    Inventor: Richard A. ZAGER
  • COMPOUNDS LINKED WITH A SACCHARIDE METAL COMPLEX AND USES THEREOF
    Publication number: 20190106454
    Abstract: The present disclosure provides compounds linked with a saccharide-metal complex. The compounds are designed to protect organs by inducing acquired cytoresistance without causing injury to the organ, among other potential uses.
    Type: Application
    Filed: March 23, 2017
    Publication date: April 11, 2019
    Inventors: Richard A. ZAGER, Julian SIMON
  • COMPOSITIONS, KITS, AND METHODS TO INDUCE ACQUIRED CYTORESISTANCE USING STRESS PROTEIN INDUCERS
    Publication number: 20190091255
    Abstract: The present disclosure provides compositions, kits, and methods to protect organs by inducing acquired cytoresistance without causing injury to the organ. The compositions, kits, and methods utilize heme proteins, iron and/or vitamin B12 and, optionally, agents that impact heme protein metabolism.
    Type: Application
    Filed: August 29, 2018
    Publication date: March 28, 2019
    Inventors: Richard ZAGER, Ali CM JOHNSON
  • Compositions, kits, and methods to induce acquired cytoresistance using stress protein inducers
    Patent number: 9844563
    Abstract: The present disclosure provides compositions, kits, and methods to protect organs by inducing acquired cytoresistance without causing injury to the organ. The compositions, kits, and methods utilize heme proteins, iron and/or vitamin B12 and, optionally, agents that impact heme protein metabolism.
    Type: Grant
    Filed: January 6, 2017
    Date of Patent: December 19, 2017
    Assignee: FRED HUTCHINSON CANCER RESEARCH CENTER
    Inventors: Richard A. Zager, Ali C M Johnson
  • COMPOSITIONS, KITS, AND METHODS TO INDUCE ACQUIRED CYTORESISTANCE USING STRESS PROTEIN INDUCERS
    Publication number: 20170112869
    Abstract: The present disclosure provides compositions, kits, and methods to protect organs by inducing acquired cytoresistance without causing injury to the organ. The compositions, kits, and methods utilize heme proteins, iron and/or vitamin B12 and, optionally, agents that impact heme protein metabolism.
    Type: Application
    Filed: January 6, 2017
    Publication date: April 27, 2017
    Inventors: Richard A. Zager, Ali CM Johnson
  • COMPOSITIONS, KITS, AND METHODS TO INDUCE ACQUIRED CYTORESISTANCE USING STRESS PROTEIN INDUCERS
    Publication number: 20160271164
    Abstract: The present disclosure provides compositions, kits, and methods to protect organs by inducing acquired cytoresistance without causing injury to the organ. The compositions, kits, and methods utilize heme proteins, iron and/or vitamin B12 and, optionally, agents that impact heme protein metabolism.
    Type: Application
    Filed: September 28, 2015
    Publication date: September 22, 2016
    Inventors: Richard Zager, Ali CM Johnson
  • Methods of Treating Acute Kidney Injury
    Publication number: 20160015701
    Abstract: Methods are provided for treating acute kidney injury in a subject, particularly ischemia-induced kidney injury and/or hypoxia-induced kidney injury. The methods comprise administering to the subject an ETA receptor antagonist, such as atrasentan or a pharmaceutically acceptable salt thereof. Methods of diagnosing and treating such kidney injuries are also provided. Methods of reducing or preventing loss of kidney function and/or renal mass or volume, and methods of delaying progression to chronic kidney disease are also provided.
    Type: Application
    Filed: March 10, 2014
    Publication date: January 21, 2016
    Inventors: Richard A. Zager, Dennis Andress
  • Treatment of ICU-associated hypocalcemia with vitamin D compounds
    Publication number: 20050261256
    Abstract: The present invention relates to a method of improving intensive care unit (ICU)-associated hypocalcemia in a mammal by the administration of a vitamin D compound, or other compounds exhibiting vitamin D-like activity, to the mammal for a sufficient period of time to improve or restore the serum calcium levels of the mammal.
    Type: Application
    Filed: July 27, 2005
    Publication date: November 24, 2005
    Inventors: Leticia Delgado-Herrera, Patricia Mershimer, Richard Zager
  • Treatment of ICU-associated hypocalcemia with vitamin D compounds
    Publication number: 20010036937
    Abstract: The present invention relates to a method of improving intensive care unit (ICU)-associated hypocalcemia in a mammal by the administration of a vitamin D compound, or other compounds exhibiting vitamin D-like activity, to the mammal for a sufficient period of time to improve or restore the serum calcium levels of the mammal.
    Type: Application
    Filed: April 6, 2001
    Publication date: November 1, 2001
    Inventors: Leticia Delgado-Herrera, Patricia Loreen Mershimer, Richard Zager