Patents by Inventor Richard Anthony Wisdom

Richard Anthony Wisdom has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Microorganism lactamase enzyme obtained therefrom and their use
    Patent number: 6423522
    Abstract: A lactamase enzyme having good stability, capable of hydrolysing an enantiomer of the bicyclic lactam, 2-azabicyclo[2.2.1]hept-5-en-3-one, to give (−) lactam and (+) amino acid, has been found in a strain of Comamonas acidivorans. The enzyme has been isolated and cloned, and its structure identified.
    Type: Grant
    Filed: February 22, 2000
    Date of Patent: July 23, 2002
    Assignee: Chirotech Technology, Ltd.
    Inventors: Richard Anthony Wisdom, Caroline Susan Lee, Robert Christopher Brown
  • Microorganism, lactamase enzyme obtained therefrom, and their use
    Patent number: 6090616
    Abstract: A lactamase enzyme having good stability, capable of hydrolysing an enatiomer of the bicyclic lactam, 2-azabicyclo[2.2.1]hept-5-en-3-one, to give (-) lactam and (+) amino acid, has been found in a strain of Comamonas acidivorans. The enzyme has been isolated and cloned, and its structure identified.
    Type: Grant
    Filed: September 3, 1997
    Date of Patent: July 18, 2000
    Assignee: Chirotech Technology, Ltd.
    Inventors: Richard Anthony Wisdom, Caroline Susan Lee, Robert Christopher Brown
  • Stereoselective hydrolysis of chiral carboxylic acid esters using esterase from ophiostoma or ceratocystis
    Patent number: 5912164
    Abstract: An organism of the genus Ophiostoma or Ceratocystis, or a material having enzymatic activity derived therefrom, is used as a stereo-specific agent, in a biotransformation reaction, for the production of an enantiomeric acid or alcohol from a mixture of enantiomers of an ester thereof.
    Type: Grant
    Filed: May 9, 1997
    Date of Patent: June 15, 1999
    Assignees: Laboratorios Menarini S.A., Chirotech Technology Limited
    Inventors: Julie Belinda Hazel Warneck, Richard Anthony Wisdom
  • Enzyme and its use in preparing (S)-pipecolic acid
    Patent number: 5733754
    Abstract: An enzyme is provided which has acylase activity capable of hydrolyzing N-acetyl-(R,S)-pipecolic acid stereoselectively to give (S)-pipecolic acid, wherein this activity is greater than that on N-acetyl-S-proline, at pH 7.5, 25.degree. C., and substrate concentration 20 g/l, in 75 mM Tris buffer. The enzyme is obtainable from the species of Alcaligenes denitrificans deposited as NCIMB 40587. A microorganism having therein the enzyme also is provided, as is a process for preparing (S)-pipecolic acid comprising contacting a mixture of enantiomers of an N-acyl-pipe colic acid with the enzyme or microorganism.
    Type: Grant
    Filed: April 8, 1996
    Date of Patent: March 31, 1998
    Assignee: Chiroscience Limited
    Inventors: Richard Anthony Wisdom, Caroline Susan Lee, Paul Maurice Ricaud