Patents by Inventor Richard B. Edwards
Richard B. Edwards has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 7608465Abstract: Immunological assays for several biological markers for thyroid disorders in a biological sample are performed in a single test with a combination of sandwich-type, sequential competitive, and serological assays by the use of particles classified into groups that are distinguishable by flow cytometry, one group for the assay of each marker. Each group of particles is coated with a different immunological binding member, and coating densities, co-coating materials, and special buffer solutions are used to adjust for differences in the sensitivities and dynamic ranges of each of the markers in the typical sample.Type: GrantFiled: September 13, 2002Date of Patent: October 27, 2009Assignee: Bio-Rad Laboratories, Inc.Inventors: Michael I. Watkins, Suknan S. Chang, Renato B. Del Rosario, Patricia A. Miranda, Timothy D. Knight, Richard B. Edwards
-
Patent number: 7569399Abstract: Heterogeneous assays for different analytes in a single biological sample are performed simultaneously in a multiplexed assay that combines flow cytometry with the use of magnetic particles as the solid phase and yields an individual result for each analyte. The particles are distinguishable from each other by characteristics that permit them to be differentiated into groups, each group carrying an assay reagent bonded to the particle surface that is distinct from the assay reagents of particles in other groups. The magnetic particles facilitate separation of the solid and liquid phases, permitting the assays to be performed by automated equipment. Assays are also disclosed for the simultaneous detection of antibodies of different classes and a common antigen specificity or of a common class and different antigen specificities.Type: GrantFiled: August 9, 2006Date of Patent: August 4, 2009Assignee: Bio-Rad Laboratories, Inc.Inventors: Michael I. Watkins, Richard B. Edwards
-
Patent number: 7465538Abstract: Heterogeneous assays for different analytes in a single biological sample are performed simultaneously in a multiplexed assay that combines flow cytometry with the use of magnetic particles as the solid phase and yields an individual result for each analyte. The particles are distinguishable from each other by characteristics that permit them to be differentiated into groups, each group carrying an assay reagent bonded to the particle surface that is distinct from the assay reagents of particles in other groups. The magnetic particles facilitate separation of the solid and liquid phases, permitting the assays to be performed by automated equipment. Assays are also disclosed for the simultaneous detection of antibodies of different classes and a common antigen specificity or of a common class and different antigen specificities.Type: GrantFiled: August 9, 2006Date of Patent: December 16, 2008Assignee: Bio-Rad Laboratories, Inc.Inventors: Michael I. Watkins, Richard B. Edwards
-
Patent number: 7271009Abstract: Immunological assays for several biological markers for thyroid disorders in a biological sample are performed in a single test with a combination of sandwich-type, sequential competitive, and serological assays by the use of particles classified into groups that are distinguishable by flow cytometry, one group for the assay of each marker. Each group of particles is coated with a different immunological binding member, and coating densities, co-coating materials, and special buffer solutions are used to adjust for differences in the sensitivities and dynamic ranges of each of the markers in the typical sample.Type: GrantFiled: April 13, 2000Date of Patent: September 18, 2007Assignee: Bio-Rad Laboratories, Inc.Inventors: Michael I. Watkins, Suknan S. Chang, Renato B. Del Rosario, Patricia A. Miranda, Timothy D. Knight, Richard B. Edwards
-
Patent number: 7205160Abstract: Heterogeneous assays for different analytes in a single biological sample are performed simultaneously in a multiplexed assay that combines flow cytometry with the use of magnetic particles as the solid phase and yields an individual result for each analyte. The particles are distinguishable from each other by characteristics that permit them to be differentiated into groups, each group carrying an assay reagent bonded to the particle surface that is distinct from the assay reagents of particles in other groups. The magnetic particles facilitate separation of the solid and liquid phases, permitting the assays to be performed by automated equipment. Assays are also disclosed for the simultaneous detection of antibodies of different classes and a common antigen specificity or of a common class and different antigen specificities.Type: GrantFiled: July 11, 2005Date of Patent: April 17, 2007Assignee: Bio-Rad Laboratories, Inc.Inventors: Michael I. Watkins, Richard B. Edwards
-
Patent number: 6960478Abstract: Heterogeneous assays for different analytes in a single biological sample are performed simultaneously in a multiplexed assay that combines flow cytometry with the use of magnetic particles as the solid phase and yields an individual result for each analyte. The particles are distinguishable from each other by characteristics that permit them to be differentiated into groups, each group carrying an assay reagent bonded to the particle surface that is distinct from the assay reagents of particles in other groups. The magnetic particles facilitate separation of the solid and liquid phases, permitting the assays to be performed by automated equipment. Assays are also disclosed for the simultaneous detection of antibodies of different classes and a common antigen specificity or of a common class and different antigen specificities.Type: GrantFiled: December 11, 2003Date of Patent: November 1, 2005Assignee: Bio-Red Laboratories, Inc.Inventors: Michael I. Watkins, Richard B. Edwards
-
Patent number: 6872578Abstract: Heterogeneous assays for different analytes in a single biological sample are performed simultaneously in a multiplexed assay that combines flow cytometry with the use of magnetic particles as the solid phase and yields an individual result for each analyte. The particles are distinguishable from each other by characteristics that permit them to be differentiated into groups, each group carrying an assay reagent bonded to the particle surface that is distinct from the assay reagents of particles in other groups. The magnetic particles facilitate separation of the solid and liquid phases, permitting the assays to be performed by automated equipment. Assays are also disclosed for the simultaneous detection of antibodies of different classes and a common antigen specificity or of a common class and different antigen specificities.Type: GrantFiled: July 13, 2001Date of Patent: March 29, 2005Assignee: Bio-Rad Laboratories, Inc.Inventors: Michael I. Watkins, Richard B. Edwards
-
Publication number: 20040126904Abstract: Heterogeneous assays for different analytes in a single biological sample are performed simultaneously in a multiplexed assay that combines flow cytometry with the use of magnetic particles as the solid phase and yields an individual result for each analyte. The particles are distinguishable from each other by characteristics that permit them to be differentiated into groups, each group carrying an assay reagent bonded to the particle surface that is distinct from the assay reagents of particles in other groups. The magnetic particles facilitate separation of the solid and liquid phases, permitting the assays to be performed by automated equipment. Assays are also disclosed for the simultaneous detection of antibodies of different classes and a common antigen specificity or of a common class and different antigen specificities.Type: ApplicationFiled: December 11, 2003Publication date: July 1, 2004Applicant: Bio-Rad Laboratories, Inc.Inventors: Michael I. Watkins, Richard B. Edwards
-
Publication number: 20010054580Abstract: Heterogeneous assays for different analytes in a single biological sample are performed simultaneously in a multiplexed assay that combines flow cytometry with the use of magnetic particles as the solid phase and yields an individual result for each analyte. The particles are distinguishable from each other by characteristics that permit them to be differentiated into groups, each group carrying an assay reagent bonded to the particle surface that is distinct from the assay reagents of particles in other groups. The magnetic particles facilitate separation of the solid and liquid phases, permitting the assays to be performed by automated equipment. Assays are also disclosed for the simultaneous detection of antibodies of different classes and a common antigen specificity or of a common class and different antigen specificities.Type: ApplicationFiled: July 13, 2001Publication date: December 27, 2001Applicant: Bio-Rad Laboratories, Inc.Inventors: Michael I. Watkins, Richard B. Edwards
-
Patent number: 6280618Abstract: Heterogeneous assays for different analytes in a single biological sample are performed simultaneously in a multiplexed assay that combines flow cytometry with the use of magnetic particles as the solid phase and yields an individual result for each analyte. The particles are distinguishable from each other by characteristics that permit them to be differentiated into groups, each group carrying an assay reagent bonded to the particle surface that is distinct from the assay reagents of particles in other groups. The magnetic particles facilitate separation of the solid and liquid phases, permitting the assays to be performed by automated equipment. Assays are also disclosed for the simultaneous detection of antibodies of different classes and a common antigen specificity or of a common class and different antigen specificities.Type: GrantFiled: April 30, 1999Date of Patent: August 28, 2001Assignee: Bio-Rad Laboratories, Inc.Inventors: Michael I. Watkins, Richard B. Edwards
-
Publication number: 20010008217Abstract: Heterogeneous assays for different analytes in a single biological sample are performed simultaneously in a multiplexed assay that combines flow cytometry with the use of magnetic particles as the solid phase and yields an individual result for each analyte. The particles are distinguishable from each other by characteristics that permit them to be differentiated into groups, each group carrying an assay reagent bonded to the particle surface that is distinct from the assay reagents of particles in other groups. The magnetic particles facilitate separation of the solid and liquid phases, permitting the assays to be performed by automated equipment. Assays are also disclosed for the simultaneous detection of antibodies of different classes and a common antigen specificity or of a common class and different antigen specificities.Type: ApplicationFiled: April 30, 1999Publication date: July 19, 2001Inventors: MICHAEL I. WATKINS, RICHARD B. EDWARDS
-
Patent number: 5616310Abstract: Process for manufacturing an alkali metal aluminosilicate of zeolite P type, wherein sodium silicate solution, sodium aluminate solution and sodium hydroxide are mixed together in a first reacting zone, the mixture reacting to form amorphous aluminosilicate and supersaturated mother liquor and being then transferred from this first reacting zone to a second reacting zone, the transferred mixure having a degree of crystallinity below 30%, preferably 20%, the mixture being afterwards allowed to fully convert into P type zeolite, the resulting product being eventually filtered, washed and dried.Type: GrantFiled: July 9, 1996Date of Patent: April 1, 1997Assignee: Crosfield LimitedInventors: Richard B. Edwards, Peter Graham
-
Patent number: 5253774Abstract: A reagent vessel and support rack for use in an automated clinical analyzer are disclosed. Characteristic features of the vessel are a membrane covering which is puncturable and preferably self-sealing, and characteristic features of the support rack are a rigid wall and retaining members to hold the vessel in the rack with the membrane against the rigid wall of the rack, thereby providing structural support to the membrane, with holes in the wall to permit access to the membrane and hence to the contents of the receptacle.Type: GrantFiled: June 26, 1992Date of Patent: October 19, 1993Assignee: Bio-Rad Laboratories, Inc.Inventors: Jordan S. Honig, Christopher J. Macko, Richard B. Edwards
-
Patent number: 4680132Abstract: Grittiness in soap-containing formulations, one source of which is the reworking of previously processed soap, is reduced in an efficient manner by passing the formulation through a cavity transfer mixer.Type: GrantFiled: February 21, 1985Date of Patent: July 14, 1987Assignee: Lever Brothers CompanyInventors: Terence A. Clarke, Richard B. Edwards, Graeme N. Irving
-
Patent number: 4517107Abstract: A soap-containing formulation capable of becoming transparent on working is subjected to shear between two mutually displaceable surfaces. A shear zone is formed in the formulation as the latter is entrained in the surfaces.Type: GrantFiled: March 14, 1984Date of Patent: May 14, 1985Assignee: Lever Brothers CompanyInventors: Terence A. Clarke, Richard B. Edwards, Graeme N. Irving
-
Patent number: 4485030Abstract: The phases present in a shear sensitive soap-containing formulation are controlled and may be changed by passing the formulation through shear zones formed by mutually displaceable surfaces. The shear zones are formed within the formulation by entraining it in the surfaces during passage between the surfaces.Type: GrantFiled: March 14, 1984Date of Patent: November 27, 1984Assignee: Lever Brothers CompanyInventors: Terence A. Clarke, Richard B. Edwards, Graeme N. Irving
-
Patent number: 4479884Abstract: The mush and/or lather properties of soap-containing material including free fatty acids can be improved by subjecting the material to working. The material is passed through the shear zone(s) formed between two mutually displaceable surfaces between which the material passes.Type: GrantFiled: March 14, 1984Date of Patent: October 30, 1984Assignee: Lever Brothers CompanyInventors: Terence A. Clarke, Richard B. Edwards, Graeme N. Irving