Patents by Inventor Richard B. Pyles

Richard B. Pyles has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cystatin C and Cystatin 9 to treat gut inflammation caused by thermal injury
    Patent number: 12053511
    Abstract: The present invention includes a composition and method of modulating a dysregulated gut-derived inflammation following a thermal injury comprising: identifying a mammal in need of treatment for the dysregulated gut-derived inflammation following the thermal injury; and providing the mammal with a recombinant Cystatin 9 (CST9) and Cystatin C (CSTC) in a synergistic amount sufficient to restrain or prevent a life-threatening, unrestrained systemic dysregulated gut-derived inflammation in the mammal caused by the thermal injury.
    Type: Grant
    Filed: June 16, 2020
    Date of Patent: August 6, 2024
    Assignee: BOARD OR REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Tonyia Eaves-Pyles, Richard B. Pyles
  • CYSTATIN C AND CYSTATIN 9 TO TREAT INFLAMMATION CAUSED BY BACTERIA
    Publication number: 20200306351
    Abstract: The present invention includes a composition and method of modulating a dysregulated gut-derived inflammation following a thermal injury comprising: identifying a mammal in need of treatment for the dysregulated gut-derived inflammation following the thermal injury; and providing the mammal with a recombinant Cystatin 9 (CST9) and Cystatin C (CSTC) in a synergistic amount sufficient to restrain or prevent a life-threatening, unrestrained systemic dysregulated gut-derived inflammation in the mammal caused by the thermal injury.
    Type: Application
    Filed: June 16, 2020
    Publication date: October 1, 2020
    Applicant: Board of Regents, The University of Texas System
    Inventors: Tonyia Eaves-Pyles, Richard B. Pyles
  • CYSTATIN C AND CYSTATIN 9 TO TREAT INFLAMMATION CAUSED BY BACTERIA
    Publication number: 20180147268
    Abstract: The present invention includes a composition and method for controlling an immune response in a host to a pathogenic bacterial infection comprising: identifying a subject in need of treatment for infection with a pathogenic bacteria; and providing a composition comprising recombinant Cystatin 9 (CST9), a cystatin C (CSTC), or both CST9 and CSTC, in an amount sufficient to restrain or prevent a life-threatening, unrestrained systemic inflammatory response syndrome in a host against a pathogenic bacteria.
    Type: Application
    Filed: November 29, 2017
    Publication date: May 31, 2018
    Applicant: Board of Regents, The University of Texas System
    Inventors: Tonyia Eaves-Pyles, Richard B. Pyles, Bernard P. Arulanandam
  • Molecular typing system for flavivirus diagnostics
    Patent number: 9771623
    Abstract: Certain embodiments of the invention include methods and compositions for evaluating flaviviruses, such as Zika virus, for the purpose of identifying, typing, and/or categorizing/speciation of virus in samples using nucleic acid sequencing.
    Type: Grant
    Filed: March 15, 2017
    Date of Patent: September 26, 2017
    Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Aaron L. Miller, Richard B. Pyles
  • MOLECULAR TYPING SYSTEM FOR FLAVIVIRUS DIAGNOSTICS
    Publication number: 20170268073
    Abstract: Certain embodiments of the invention include methods and compositions for evaluating flaviviruses, such as Zika virus, for the purpose of identifying, typing, and/or categorizing/speciation of virus in samples using nucleic acid sequencing.
    Type: Application
    Filed: March 15, 2017
    Publication date: September 21, 2017
    Inventors: Aaron L. Miller, Richard B. Pyles
  • Methods and compositions for identifying enterovirus
    Patent number: 9518303
    Abstract: Certain embodiments of the invention include, but are not limited to PCR primer pairs, sequencing primers, and/or associated thermocycling protocols targeting a region identified by the inventors within the 5? untranslated region of enteroviruses for the purpose of identifying, subtyping, and/or classifying of virus in samples using nucleic acid sequencing. The sequencing procedures can use nucleic acid templates, such as cDNA or PCR amplicons, as a template for sequencing in medium to high throughput format that is cost effective and easily deployed to other clinical microbiology laboratories.
    Type: Grant
    Filed: October 25, 2012
    Date of Patent: December 13, 2016
    Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Richard B. Pyles, Aaron L. Miller
  • METHODS AND COMPOSITIONS FOR IDENTIFYING ENTEROVIRUS
    Publication number: 20150292041
    Abstract: Certain embodiments of the invention include, but are not limited to PCR primer pairs, sequencing primers, and/or associated thermocycling protocols targeting a region identified by the inventors within the 5? untranslated region of enteroviruses for the purpose of identifying, subtyping, and/or classifying of virus in samples using nucleic acid sequencing. The sequencing procedures can use nucleic acid templates, such as cDNA or PCR amplicons, as a template for sequencing in medium to high throughput format that is cost effective and easily deployed to other clinical microbiology laboratories.
    Type: Application
    Filed: October 25, 2012
    Publication date: October 15, 2015
    Applicant: The Board of Regents of the University of Texas System
    Inventors: Richard B. Pyles, Aaron L. Miller