Abstract: Devices used to pressurize, depressurize, or otherwise displace fluid are disclosed. The devices may be configured to displace fluid in order to inflate or deflate a medical device, such as a balloon. The devices further include features and mechanisms for limiting pressure generation so as to avoid damage due to overpressurization.

Abstract: A system and method for data allocation in a shared cache memory of a computing system are contemplated. Each cache way of a shared set-associative cache is accessible to multiple sources, such as one or more processor cores, a graphics processing unit (GPU), an input/output (I/O) device, or multiple different software threads. A shared cache controller enables or disables access separately to each of the cache ways based upon the corresponding source of a received memory request. One or more configuration and status registers (CSRs) store encoded values used to alter accessibility to each of the shared cache ways. The control of the accessibility of the shared cache ways via altering stored values in the CSRs may be used to create a pseudo-RAM structure within the shared cache and to progressively reduce the size of the shared cache during a power-down sequence while the shared cache continues operation.

Abstract: A system and method for data allocation in a shared cache memory of a computing system are contemplated. Each cache way of a shared set-associative cache is accessible to multiple sources, such as one or more processor cores, a graphics processing unit (GPU), an input/output (I/O) device, or multiple different software threads. A shared cache controller enables or disables access separately to each of the cache ways based upon the corresponding source of a received memory request. One or more configuration and status registers (CSRs) store encoded values used to alter accessibility to each of the shared cache ways. The control of the accessibility of the shared cache ways via altering stored values in the CSRs may be used to create a pseudo-RAM structure within the shared cache and to progressively reduce the size of the shared cache during a power-down sequence while the shared cache continues operation.

Abstract: Compounds of formulas 1 through 17 provided in the specification specifically or selectively inhibit either the cytochrome P450RAI-1 enzyme or the cytochrome P450RAI-2 enzyme.

Abstract: By providing at least two hardware representations of a specified circuit design, an efficient debugging system is provided that allows 100% design visibility at an extremely reduced simulation time owing to a time-shifted operation of the at least two hardware representations. Upon detection of a specified abort state in the leading hardware representation, the corresponding delayed state of the time-shifted hardware representation may be used for a subsequent simulation of only a relevant portion of the test run that has lead to the specified abort state.

Abstract: The invention provides methods for treating an individual having a retinoid responsive disorder. In one embodiment, a method involves administering to the individual an effective amount of a selective CYP26B inhibitor, the selective CYP26B inhibitor having at least 10-fold selectivity for CYP26B relative to CYP26A. In another embodiment, a method involves administering to the individual an effective amount of a selective CYP26A inhibitor, the selective CYP26A inhibitor having a chemical formula set forth in the specification. The invention further provides screening methods for identifying a selective CYP26A inhibitor or selective CYP26B inhibitor.

Abstract: Compounds of formulas 1 through 17 provided in the specification specifically or selectively inhibit either the cytochrome P450RAI-1 enzyme or the cytochrome P450RAI-2 enzyme.

Abstract: Compounds of formulas 1 through 17 provided in the specification specifically or selectively inhibit either the cytochrome P450RAI-1 enzyme or the cytochrome P450RAI-2 enzyme.

Abstract: A unified user input device is provided. The input device may include keys normally provided as part of a general purpose alphanumeric computer keyboard. In addition, a positional controller is provided. Both the conventional alphanumeric keys and the positional controller are associated with the same device platform. Additionally, special function keys may also be provided in association with the positional controller. Signals encoding the selection of an alphanumeric key, a control input, or a special function key are communicated to an interconnected computer using a common, conventional keyboard connection, and a common signaling protocol.

Abstract: The invention provides methods for treating an individual having a retinoid responsive disorder. In one embodiment, a method involves administering to the individual an effective amount of a selective CYP26B inhibitor, the selective CYP26B inhibitor having at least 10-fold selectivity for CYP26B relative to CYP26A. In another embodiment, a method involves administering to the individual an effective amount of a selective CYP26A inhibitor, the selective CYP26A inhibitor having a chemical formula set forth in the specification. The invention further provides screening methods for identifying a selective CYP26A inhibitor or selective CYP26B inhibitor.

Abstract: Compounds of formulas 1 through 17 provided in the specification specifically or selectively inhibit either the cytochrome P450RAI-1 enzyme or the cytochrome P450RAI-2 enzyme.

Abstract: Compounds of the formula where the variables have the meaning defined in the specification are capable of reducing serum glucose levels in diabetic mammals without the undesirable side effects of transiently increasing triglyceride levels and reducing serum thyroxine levels.

Abstract: A tissue product containing a multi-layered paper web that has at least one outer layer formed from a blend of pulp fibers and synthetic fibers is provided. A polymer latex is also applied to the outer layer of the tissue product. It is believed that the polymer latex and synthetic fibers can fuse together to have a synergistic effect on the strength of the tissue product. In addition, the resulting tissue product can be soft and produce low levels of lint and slough.

Abstract: Methods for modulating the activity of the mammalian BAR/FXR receptor. The methods include methods of treating a hypocholesterolemic mammal comprising contacting the mammal with synthetic compounds able to modulate an activity characteristic of the BAR/FXR receptor. Other methods include a method of treating colon cancer in a mammal comprising administering a compound having a BAR/FXR antagonistic activity.

Abstract: A tissue product containing a multi-layered paper web that has at least one outer layer formed from a blend of pulp fibers and synthetic fibers is provided. A polymer latex is also applied to the outer layer of the tissue product. It is believed that the polymer latex and synthetic fibers can fuse together to have a synergistic effect on the strength of the tissue product. In addition, the resulting tissue product can be soft and produce low levels of lint and slough.

Abstract: The invention provides a data visulisation system comprising a data value memory in which is maintained an interaction database of interaction data representing interactions between customers and merchants, the interaction data associated with at least one time value, a retrieval device arranged to retrieve from the interaction database data representing interactions between customers and merchants and to construct a finite set of data values from their retrieved data, a display arranged to display a first representation of the data values, and a pointing device enabling a user to select part of the first representation. The display is further arranged to generate and display a second representation based on the part of the first representation selected by the user.

Abstract: Compounds of the formula where the variables have the meaning defined in the specification, which bind specifically or selectively to to RAR&agr; retinoid receptors.