Abstract: Recombinant immunotoxins are fusion proteins composed of the Fv domains of antibodies fused to bacterial or plant toxins. RFB4 (Fv)-PE38 is an immunotoxin that targets CD22 expressed on B cells and B cell malignancies. The present invention provides antibodies and antibody fragments that have improved ability to bind the CD22 antigen of B cells and B cell malignancies compared to RFB4. Immunotoxins made with the antibodies and antibody fragments of the invention have improved cytotoxicity to CD22-expressing cancer cells. Compositions that incorporate these antibodies into chimeric immunotoxin molecules that can be used in medicaments and methods for inhibiting the growth and proliferation of leukemia and lymphoma cells.

Abstract: CD30 is a receptor expressed on cells of Hodgkin's disease and certain leukemias. The extracellular portion of CD30 is cleaved, releasing a form known as sCD30. The invention relates in part to the discovery that a residual, extracellular “stalk” of CD30 remains after cleavage of sCD30. The stalk provides an advantageous and previously unrecognized target for immunotoxins. The invention provides antibodies that bind to the CD30 stalk or to epitopes destroyed upon the cleavage of CD30 which results in the stalk. The invention further provides new anti-CD30 antibodies that form effective immunotoxins and are particularly suitable for making disulfide stabilized Fv (“dsFv”)-immunoconjugates. The dsFv immunoconjugates can be used as reagents to label CD30-expressing cancer cells or to inhibit the growth of CD30-expressing cancer cells. Moreover, the invention provides anti-CD30 antibodies that activate complement-dependent cytotoxicity.

Abstract: A method for conducting a checkless cash advance settlement is provided, including the following steps: (1) a customer initiates a Debit or Credit POS transaction via a gaming machine; (2) the customer receives authorization or denial; (3) the customer provides his identification and the credit/debit card to a cashier/attendant at the gaming station; (4) the cashier or attendant validates the customer's identity, retrieves the transaction information, and completes the cash advance application; (5) the application prints a non-negotiable instrument, such as a transaction receipt; (6) the customer signs the receipt confirming the transaction with a physical receipt or electronic capture; (7) the receipt image is stored electronically for subsequent transmittal to a central server; (8) the transaction information, including the receipt image if applicable, is recorded on the central server; and (9) the central server generates an ACH file and electronically transmits the ACH file to the casino's designated fina

Abstract: Recombinant immunotoxins are fusion proteins composed of the Fv domains of antibodies fused to bacterial or plant toxins. RFB4 (Fv)-PE38 is an immunotoxin that targets CD22 expressed on B cells and B cell malignancies. The present invention provides antibodies and antibody fragments that have improved ability to bind the CD22 antigen of B cells and B cell malignancies compared to RFB4. Immunotoxins made with the antibodies and antibody fragments of the invention have improved cytotoxicity to CD22-expressing cancer cells. Compositions that incorporate these antibodies into chimeric immunotoxin molecules that can be used in medicaments and methods for inhibiting the growth and proliferation of leukemia and lymphoma cells.

Abstract: Systems and methods that provide casino cash bonuses and other incentives in connection with cash access services to promote casino patron loyalty and lower costs and expenses per transaction. The methods of distributing bonuses to casino patrons further provide incentives that maximize cash access transactions and promote and increase casino patron gaming in the casino.

Abstract: The invention provides antibodies to a mutant form of the epidermal growth factor receptor known as EGFRvIII found only or primarily on the surface of glioblastoma cells, and on cells of breast, ovarian and non-small cell lung carcinomas. The antibodies provided by the invention have the complementarity determining regions (“CDRs”) of the scFv designated MR1, but with mutations at positions 98 and 99 in the CDR3 of the heavy chain variable region and, optionally, in other CDRs. In particular, the invention provides an antibody, designated MR1-1, which mutates MR1 in the CDR3 of the VH and VL chains. The invention provides additional antibodies in which MR1 is mutated in the CDR1 and 2 of VH or VL, or both.

Abstract: CD30 is a receptor expressed on cells of Hodgkin's disease and certain leukemias. The extracellular portion of CD30 is cleaved, releasing a form known as sCD30. The invention relates in part to the discovery that a residual, extracellular “stalk” of CD30 remains after cleavage of sCD30. The stalk provides an advantageous and previously unrecognized target for immunotoxins. The invention provides antibodies that bind to the CD30 stalk or to epitopes destroyed upon the cleavage of CD30 which results in the stalk. The invention further provides new anti-CD30 antibodies that form effective immunotoxins and are particularly suitable for making disulfide stabilized Fv (“dsFv”)-immunoconjugates. The dsFv immunoconjugates can be used as reagents to label CD30-expressing cancer cells or to inhibit the growth of CD30-expressing cancer cells. Moreover, the invention provides anti-CD30 antibodies that activate complement-dependent cytotoxicity.

Abstract: A checkless cash advance settlement system and method are provided, including the following steps: (1) a customer initiates a Debit or Credit POS transaction via one of several possible systems, e.g., Kiosk, ATM or wireless device; (2) the customer receives authorization or denial from the selected system; (3) if authorized, the customer proceeds to the cashier's cage or central cage station and provides to a cashier on identification card and the credit/debit card used to initiate the transaction; alternatively, if the customer initiated the transaction on a wireless device, e.g.

Abstract: Recombinant immunotoxins are fusion proteins composed of the Fv domains of antibodies fused to bacterial or plant toxins. RFB4 (Fv)-PE38 is an immunotoxin that targets CD22 expressed on B cells and B cell malignancies. The present invention provides antibodies and antibody fragments that have improved ability to bind the CD22 antigen of B cells and B cell malignancies compared to RFB4. Immunotoxins made with the antibodies and antibody fragments of the invention have improved cytotoxicity to CD22-expressing cancer cells. Compositions that incorporate these antibodies into chimeric immunotoxin molecules that can be used in medicaments and methods for inhibiting the growth and proliferation of leukemia and lymphoma cells.

Abstract: A system and method are provided for performing a cashless gaming ticket redemption transaction for a customer in a casino environment. The system includes a gaming machine, such as a slot machine, that the customer plays. Rather than issuing cash to the customer, the gaming machine issues a redemption ticket with a unique identifier to the customer. The unique identifier and the amount of the customer's winnings accrued on the gaming machine are stored and associated on a redemption ticket database. When the customer wishes to redeem the winnings, the redemption ticket is introduced to a multi-function ATM. To perform the ticket redemption transaction, the ATM is adapted to electronically accept the redemption ticket and read the unique identifier. The ATM then electronically communicates with the redemption database to retrieve the predetermined dollar value associated with the unique identifier. Finally, the ATM transfers to the customer an award equal to the predetermined dollar value in cash or credit.

Abstract: The present invention relates to a system and method for integrating player tracking and cash access in a casino or other gaming environment. One aspect of the invention allows for fund access and management wherein gaming machines, such as slot machines, receive playable credits directly from a patron's banking or credit card account. Another aspect of the present invention relates to integrating player tracking and cash access transactions by allowing the players to provide a player tracking card for each financial transaction conducted in the casino. In return, the casino issues gaming or bonus points to the players for allowing their transactions to be tracked. Yet another aspect of the present invention consolidates the players' financial account information into a single casino database.

Abstract: A system and method is disclosed for creating and/or maintaining an electrical load on a diesel engine generator for use on a marine vessel in order to avoid the harmful effects of no-load or low-load operation of the diesel engine. The parasitic load bank system 10 utilizes the heat transfer fluid 23 contained in the closed circulation loop 28 of a chille7d-fluid air conditioning system 14 for creating and/or maintaining the electrical load on the diesel engine generator 12 by utilizing a load bank controller 44 for diverting a portion 23c of the heat transfer fluid 23a being supplied to the vessel's air handlers 42 into heat exchange relationship with the heat transfer fluid 20b discharged from the air conditioning system's source of heat transfer 18 such that the heat exchanged heat transfer fluid 23f activates the source of heat transfer 18, which may be a chiller, reverse-cycle chiller or heat pump, to create an electrical power demand on the diesel engine generator 12.

Abstract: The invention provides antibodies for a mutant form of the epidermal growth factor receptor known as EGFRvIII. This mutant is found only or primarily on the surface of glioblastoma cells, and on cells of breast, ovarian and non-small cell lung carcinomas. The antibodies provided by the invention have higher affinity for EGFRvIII, and form immunotoxins with higher cytotoxicity and yield, than prior art antibodies, including the scFv designated MR1. In particular, the invention provides an antibody, designated MR1-1, which mutates MR1 in the CDR3 of the VH and VL chains to provide an antibody with especially good cytotoxicity. The invention provides additional antibodies in which MR1 is mutated in the CDR1 and 2 of VH or VL, or both, with better binding to EGFRvIII than that of the parental MR1 antibody.

Abstract: The invention relates to a method for the production of two-component ice cream, in which a core of ice cream, the surface of which is cooled to at least about −15° C., is dipped into a fat-containing coating solution, in order to form a coating layer, and to the two-component ice cream which can be obtained with the method. Thereby, the fat content of the coating solution should be at least about 10%.

Abstract: A plasma processor for large workpieces includes a vacuum chamber having plural individually supported dielectric windows for coupling an r.f. field originating outside of the chamber into the chamber to excite the plasma. A planar coil for inductively deriving the field has plural segments with the same electrical length, each including an element connected in parallel with an element of another segment.

Abstract: In a process for producing composite confection products, comprising a plurality of superimposed confection layers formed from extruded strands, in particular of ice cream, of which at least one is wave-shaped and may overlap itself, the confection layers are extruded on to a conveyor belt and to produce the wave shape the component of movement of the extruded material is greater than the movement of the conveyor belt so that at least a first point of deposition of the leading end of the strand issuing from at least one extrusion nozzle is displaced laterally relative to the vertical movement of the extrusion strand from the outlet to the plane of deposition of the conveyor belt so that the pasty confection material is deposited laterally under its own weight due to a lateral displacement of the center of gravity of the strand, and that the conveyor belt is displaced laterally at the latest when at least one loop comprising at least two superimposed strand sections has been formed.

Abstract: A shaped body of ice cream built up of layers is described. The individual layers (3) of ice cream consist of extruded strands (2) that are laid down in the form of curves, for example an eight, beside and on top of one another.Further, an apparatus for preparing such shaped bodies is described wherein a plurality of nozzles are arranged side by side and with the outlets underneath in a moveably mounted support plate. The supply side of each nozzle is connected via a supply line with a distributor head and the support plate is moved in curves by means of a mechanism. A moveable substrate for the extrudate, for example a conveyor belt or a tray, is arranged underneath the nozzles.

Abstract: Apparatus for the production of spherical portions of ice-cream. The apparatus includes means forintroducing an ice-cream mixture having a creamy consistency into a hemispherical lower mould in a sufficient quantity to fill the mould and form a protruding cap having the same volume as that of the mould;means for smoothing the protruding cap into the shape of a hemisphere being a smoothing tool comprising a portion of the generatrix of a hemisphere which describes on rotation a hemispherical shape;means for freezing the completed sphere of ice-cream; andmeans for removing the sphere of ice-cream from the mould.The smoothing tool has the shape of a hemisphere, onto the crown of which there is fastened an extension piece, its generatrix being perforated in between some remaining segments.