Abstract: A system and method are provided for determining a processing engine to process a request from a client in a distributed client-server architecture. Requests from the clients are handled by a request management module, which determines a processing entity for each request. A processing entity may be one or more processing engines, or one or more additional request management modules in conjunction with additional processing engines. Processing entities register with the request management module as available to process the requests. Processing entities may be determined based on the information supplied in the requests, such as, for example, required characteristics of the processing entities. Once the processing entity is determined, the request is transferred to that processing entity, where the request is processed. Results of processing the request are transferred to the original request management module, from where they are transferred back to the requesting client.

Abstract: The compounds of formula I, ##STR1## wherein the substituents have various significances, and physiologically acceptable hydrolyzable derivatives thereof having the hydroxy group in the 2 position of the 3-aminopropoxy side chain in esterified form, are useful as cardioselective .beta.-adrenoceptor blocking agents.

Abstract: Compounds of formula (I), ##STR1## characterized in that R signifies optionally substituted heteroaryl-, heteroarylakyl or heteroarylalkenyl, R.sub.1 signifies hydrogen or a substituent, R.sub.2 is hydroxy or a group --z--(CH.sub.2).sub.n --Y--R.sub.3 wherein R.sub.3 is hydrogen, alkyl, hydroxyalkyl, alkenyl, cycloalkyl, cycloalkylalkylene, hydroxy substituted cycloalkyl or cycloalkylalkylene, or optionally substituted aryl or aralkyl or aralkenyl moiety, and Y signifies oxygen or sulfur, and either Z is an oxygen atom and n is 2 or 3, or Z is a bond and n is 1, 2 or 3, A signifies alkylene or branched alkylene of 2 to 5 carbon atoms, W signifies a bond or imino, and X signifies a bond or imino, and their physiologically hydrolyzable derivatives, in which at least one hydroxy group is in esterified form. The compounds exhibit beta adrenoceptor blocking activity. Processes for the preparation of the compounds are also disclosed.

Abstract: The compounds of formula I, ##STR1## where the substituents have various significances, and physiologically acceptable hydrolyzable derivatives thereof having the hydroxy group in the 2 position of the 3-aminopropoxy side chain in esterified form, are useful as cardioselective .beta.-adrenoceptor blocking agents.

Abstract: The compounds of formula I, ##STR1## where the substituents have various significances, and physiologically acceptable hydrolyzable derivatives thereof having the hydroxy group in the 2 position of the 3-aminopropoxy side chain in esterifield form, are useful as cardioselective .beta.-adrenoceptor blocking agents.

Abstract: The compounds of formula I, ##STR1## wherein the substituents have various significances, and physiologically hydrolyzable derivative thereof having at least one hydroxy group in esterified form, are useful as cardioselective .beta.-adrenoceptor blocking and cardiotonic agents.

Abstract: Pharmaceutical composition containing as active agents (A) a calcium antagonist of a 4-(2,1,3-benz-oxa- or thiadiazoly)-1,4-dihydro pyridine type and (B) a .beta.-blocker and/or a vasodilating nitrate, effective against coronary heart disease and hypertension.

Abstract: The compounds of formula I, ##STR1## where R.sub.1, R.sub.2 and R.sub.3 have various significances, and physiologically acceptable hydrolyzable derivatives thereof having the hydroxy group in the 2 position of the 3-aminopropoxy side chain in esterified form, are useful as cardiotonic, antiarrhythmic, .alpha.- and .beta.-adrenoceptor blocking agents.

Abstract: The compounds of formula I, ##STR1## wherein the substituents have various significances, and physiologically acceptable hydrolyzable derivatives thereof having the hydroxy group in the 2 position of the 3-aminopropoxy side chain in esterified form, are useful as cardioselective .beta.-adrenoceptor blocking agents.

Abstract: Compounds of formula I ##STR1## wherein (i) m is O, n is 2 and p is 1 or(ii) m is 0 or 1, n is 1, and p is 1 or(iii) m is 1, n is 1 or 2 and p is 0,R.sub.1 is (i) alkyl of 3 to 7 carbon atoms or (ii) phenylalkyl, phenoxyalkyl or phenylthioalkyl of 8 to 11 carbon atoms in the aggregate thereof and wherein the phenyl ring is separated by at least 2 carbon atoms from the nitrogen atom to which R.sub.1 is bound and wherein the phenyl ring is unsubstituted, or mono-substituted by, or independently disubstituted by, alkyl or alkoxy of 1 to 4 carbon atoms, halogen of atomic number from 9 to 35, trifluoromethyl or cyano,R.sub.2 and R.sub.3 are either together straight chain alkylene of 4 to 6 carbon atoms, or, independently, hydrogen or alkyl of 1 to 4 carbon atoms, with the proviso that when m is 1, n is 1 and p is 0 then at least one of R.sub.2 and R.sub.3 is other than hydrogen, andR.sub.4 and R.sub.5 are, independently, hydrogen or alkyl of 1 to 4 carbon atoms, are useful in the treatment of coronary disorders.

Abstract: The compounds of formula I ##STR1## where R.sub.1, R.sub.2 and R have various significances, and physiologically acceptable hydrolyzable derivatives thereof having the hydroxy group in the 2 position of the 3-aminopropoxy side chain in esterified form, are useful as cardiotonic, anti-arrhythmic, .alpha.- and .beta.-adrenoceptor blocking agents.

Abstract: The present invention relates to a compound of formula I, ##STR1## wherein A is straight chain alkylene of 2 to 4 carbon atoms, or straight chain alkenylene of 2 to 4 carbon atoms,n is 1, 2 or 3,R is hydrogen or halogen of atomic number from 9 to 35, andeither (i) R.sub.1 is a group of formula II, ##STR2## wherein R.sub.2 and R.sub.3, independently, are hydrogen or alkyl of 1 to 4 carbon atoms, andR.sub.4 is alkyl of 1 to 4 carbon atoms, alkoxyalkyl of 2 to 5 carbon atoms, alkylthioalkyl of 2 to 5 carbon atoms, phenylalkyl or phenoxyalkyl or phenylthioalkyl, wherein the alkyl moiety has from 1 to 3 carbon atoms, or phenyl, the phenyl ring of each of the last four radicals being unsubstituted or mono-substituted by, or disubstituted independently by, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, hydroxy or halogen of atomic number from 9 to 35, andR.sub.5 is hydrogen,or (ii) R.sub.1 and R.sub.

Abstract: The compounds of formula I ##STR1## wherein R.sub.1 is hydrogen or methyl,R.sub.3 is hydrogen, methyl, hydroxymethyl, carboxyl, alkoxycarbonyl of 2 to 5 carbon atoms, carbamoyl or cyano andR.sub.2 is a group (a) to (i), groups (a) to (i) having the following significances: ##STR2## wherein n is 0 or 1 and R.sub.a, R.sub.b, R.sub.c and R.sub.d independently are hydrogen or alkyl of 1 to 4 carbon atoms; ##STR3## wherein R.sub.e is hydrogen or alkyl of 1 to 4 carbon atoms; ##STR4## wherein R.sub.h is halogen of atomic number of from 9 to 35; ##STR5## wherein R.sub.i together with R.sub.n is o-phenylene optionally substituted by alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms or halogen of atomic number of from 9 to 35 and,when R.sub.3 is cyano,R.sub.i together with R.sub.n additionally is lower alkylene separating by 2 or 3 carbon atoms the nitrogen atom to which R.sub.i is bound from the nitrogen atom to which R.sub.n is bound andR.sub.

Abstract: The compounds of formula I ##STR1## wherein R is a group ##STR2## wherein A is alkylene of 2 to 5 carbon atoms,X is a bond, oxygen or sulfur,R.sub.3 is hydrogen, hydroxy, alkoxy of 1 to 4 carbon atoms, halogen of atomic member of from 9 to 35, cyano, carbamoyl or a group NHCOR.sub.d, wherein R.sub.d is alkyl of 1 to 4 carbon atoms, andR.sub.4 is hydrogen and, when R.sub.3 is alkoxy of 1 to 4 carbon atoms, R.sub.4 additionally may be alkoxy of 1 to 4 carbon atoms or, when R.sub.3 is halogen of atomic number of from 9 to 35, R.sub.4 additionally may be halogen of atomic number of from 9 to 35 either(i) R.sub.1 is hydrogen or methyl andR.sub.2 is cyano, CONR.sub.a R.sub.b, COOR.sub.c or CH.sub.2 OR.sub.e, wherein R.sub.a, R.sub.b, R.sub.c and R.sub.e independently are hydrogen or alkyl of 1 to 4 carbon atoms,or(ii) either R.sub.1 is methyl and R.sub.2 is halogen of atomic number of from 17 to 35or R.sub.1 is halogen of atomic number of from 17 to 35 and R.sub.

Abstract: This invention provides new compounds of formula I, ##STR1## wherein Het is a radical formed by removing one of the hydrogens from the phenyl ring of 2-indolinone or fluorenone, andR is the group A, B, C or D, ##STR2## wherein N IS THE NUMBER 2 OR 3,n' is the number 1, 2, 3 or 4, andX-x' is ethylene or vinylene,Wherein in group D each of the two C atoms adjacent to the N atom are identically substituted by hydrogen or by one or two alkyl groups of 1 to 4 carbon atoms useful as antiarrhythmic agents.

Abstract: The present invention provides compounds of formula I, ##STR1## wherein R.sub.1 and R.sub.2 are, independently, hydrogen, fluorine, chlorine, trifuoromethyl, alkyl of 1 to 4 carbon atoms, or alkoxy of 1 to 4 carbon atoms, andR.sub.3 is hydrogen, or alkoxy of 1 to 4 carbon atoms, with the proviso that when R.sub.3 is alkoxy then at least one of R.sub.1 and R.sub.2 is alkoxy, orR.sub.1 and R.sub.2 are bound to adjacent ring carbon atoms and are together --(CH.sub.2).sub.m --, wherein m is 3 or 4, --CH.dbd.CH--CH.dbd.CH--, or --O--CH.sub.2 --X--, wherein X is --O-- or --CH.sub.2 --, andR.sub.3 is hydrogen, fluorine, chlorine, trifluoromethyl, alkyl of 1 to 4 carbon atoms, or alkoxy of 1 to 4 carbon atoms,Useful as hypolipidemic agents and anti-arrhythmics.

Abstract: The invention provides new (3aRS,4SR,7aRS)-4-phenyl-hexahydro-4-indolinol derivatives useful as anti-depressants and anti-arrhythmics.

Abstract: This invention provides new compounds of formula I, ##STR1## wherein R.sub.1 is hydrogen or alkyl of 1 to 5 carbon atoms,R.sub.2 is a group ##STR2## wherein N IS A WHOLE NUMBER FROM 0 TO 3,R.sub.5 and R.sub.6, independently, are hydrogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, halogen of atomic number from 9 to 35, or together are 3,4-methylenedioxy,R.sub.7 is hydrogen, or when both R.sub.5 and R.sub.6 are alkoxy of 1 to 4 carbon atoms also may be alkoxy of 1 to 4 carbon atoms,R.sub.3 is hydrogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, or halogen of atomic number from 9 to 35, andR.sub.4 is hydrogen or alkoxy of 1 to 4 carbon atoms,Useful as sleep-promoting agents, and anti-aggressive agents.

Abstract: This invention provides new compounds of formula I, ##STR1## wherein R.sub.1 to R.sub.3 are hydrogen or optionally substituted hydrocarbyl substituents, andR.sub.5 and R.sub.6 are hydrogen, halogen, alkoxy or alkylthio,Useful as anti-hypertensive agents.

Abstract: This invention provides new compounds of formula I, ##STR1## wherein N IS A WHOLE NUMBER FROM 1 TO 3,R.sub.1 is hydrogen, or halogen of atomic number from 9 to 35,Each of the two radicals R.sub.2 are the same, and each is hydrogen or alkyl of 1 to 4 carbon atoms,Each of the two radicals R.sub.3 are the same, and each is hydrogen or alkyl of 1 to 4 carbon atoms, andX is carbonyl or methylene,Useful as anti-arrhythmics.