Patents by Inventor Richard Bethell

Richard Bethell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DIOXOLANE ANALOGUES OF URIDINE FOR THE TREATMENT OF CANCER
    Publication number: 20230382931
    Abstract: The invention provides compounds of the formula: R1 is OR11, or NR5R5?; R2 is H or F; R5 is H, C1-C6alkyl, OH, C(?O)R6, O(C?O)R6 or O(C?O)OR6; R5? is H or C1-C6alkyl; R6 is C1-C6alkyl or C3-C7cycloalkyl; R13 is H, phenyl, pyridyl, benzyl, indolyl or naphthyl wherein the phenyl, pyridyl, benzyl, indolyl and naphthyl is optionally substituted with 1, 2 or 3 R22; and the other variables are as defined in the claims, which are of use in the treatment of cancer, and related aspects.
    Type: Application
    Filed: May 31, 2023
    Publication date: November 30, 2023
    Inventors: Richard BETHELL, Anders ENEROTH, Bjorn KLASSON, Fredrik OBERG
  • DIOXOLANE ANALOGUES OF URIDINE FOR THE TREATMENT OF CANCER
    Publication number: 20230117570
    Abstract: The invention provides compounds of the formula: R1 is OR11, or NR5R5?; R2 is H or F; R5 is H, C1-C6alkyl, OH, C(?O)R6, O(C?O)R6 or O(C?O)OR6; R5? is H or C1-C6alkyl; R6 is C1-C6or C3-C7cycloalkyl; R13 is H, phenyl, pyridyl, benzyl, indolyl or naphthyl wherein the phenyl, pyridyl, benzyl, indolyl and naphthyl is optionally substituted with 1, 2 or 3 R22; and the other variables are as defined in the claims, which are of use in the treatment of cancer, and related aspects.
    Type: Application
    Filed: September 19, 2022
    Publication date: April 20, 2023
    Inventors: Richard BETHELL, Anders ENEROTH, Bjorn KLASSON, Fredrik OBERG
  • Dioxolane analogues of uridine for the treatment of cancer
    Patent number: 11447511
    Abstract: The invention provides compounds of the formula: R1 is OR11, or NR5R5?; R2 is H or F; R5 is H, C1-C6alkyl, OH, C(?O)R6, O(C?O)R6 or O(C?O)OR6; R5? is H or C1-C6alkyl; R6 is C1-C6alkyl or C3-C7cycloalkyl; R13 is H, phenyl, pyridyl, benzyl, indolyl or naphthyl wherein the phenyl, pyridyl, benzyl, indolyl and naphthyl is optionally substituted with 1, 2 or 3 R22; and the other variables are as defined in the claims, which are of use in the treatment of cancer, and related aspects.
    Type: Grant
    Filed: November 2, 2020
    Date of Patent: September 20, 2022
    Assignee: MEDIVIR AB
    Inventors: Richard Bethell, Anders Eneroth, Bjorn Klasson, Fredrik Oberg
  • DIOXOLANE ANALOGUES OF URIDINE FOR THE TREATMENT OF CANCER
    Publication number: 20210054008
    Abstract: The invention provides compounds of the formula: R1 is OR11, or NR5R5?; R2 is H or F; R5 is H, C1-C6alkyl, OH, C(?O)R6, O(C?O)R6 or O(C?O)OR6; R5? is H or C1-C6alkyl; R6 is C1-C6alkyl or C3-C7cycloalkyl; R13 is H, phenyl, pyridyl, benzyl, indolyl or naphthyl wherein the phenyl, pyridyl, benzyl, indolyl and naphthyl is optionally substituted with 1, 2 or 3 R22; and the other variables are as defined in the claims, which are of use in the treatment of cancer, and related aspects.
    Type: Application
    Filed: November 2, 2020
    Publication date: February 25, 2021
    Inventors: Richard BETHELL, Anders ENEROTH, Bjorn KLASSON, Fredrik OBERG
  • Dioxolane analogues of uridine for the treatment of cancer
    Patent number: 10822360
    Abstract: The invention provides compounds of the formula: R1 is OR11, or NR5R5?; R2 is H or F; R5 is H, C1-C6alkyl, OH, C(?O)R6, O(C?O)R6 or O(C?O)OR6; R5? is H or C1-C6alkyl; R6 is C1-C6alkyl or C3-C7cycloalkyl; R13 is H, phenyl, pyridyl, benzyl, indolyl or naphthyl wherein the phenyl, pyridyl, benzyl, indolyl and naphthyl is optionally substituted with 1, 2 or 3 R22; and the other variables are as defined in the claims, which are of use in the treatment of cancer, and related aspects.
    Type: Grant
    Filed: April 13, 2020
    Date of Patent: November 3, 2020
    Assignee: MEDIVIR AB
    Inventors: Richard Bethell, Anders Eneroth, Bjorn Klasson, Fredrik Oberg
  • DIOXOLANE ANALOGUES OF URIDINE FOR THE TREATMENT OF CANCER
    Publication number: 20200239502
    Abstract: The invention provides compounds of the formula: R1 is OR11, or NR5R5?; R2 is H or F; R5 is H, C1-C6alkyl, OH, C(?O)R6, O(C?O)R6 or O(C?O)OR6; R5? is H or C1-C6alkyl; R6 is C1-C6alkyl or C3-C7cycloalkyl; R13 is H, phenyl, pyridyl, benzyl, indolyl or naphthyl wherein the phenyl, pyridyl, benzyl, indolyl and naphthyl is optionally substituted with 1, 2 or 3 R22; and the other variables are as defined in the claims, which are of use in the treatment of cancer, and related aspects.
    Type: Application
    Filed: April 13, 2020
    Publication date: July 30, 2020
    Inventors: Richard BETHELL, Anders ENEROTH, Bjorn KLASSON, Fredrik OBERG
  • Dioxolane analogues of uridine for the treatment of cancer
    Patent number: 10654877
    Abstract: The invention provides compounds of the formula: R1 is OR11, or NR5R5?; R2 is H or F; R5 is H, C1-C6alkyl, OH, C(?O)R6, O(C?O)R6 or O(C?O)OR6; R5? is H or C1-C6alkyl; R6 is C1-C6alkyl or C3-C7cycloalkyl; R13 is H, phenyl, pyridyl, benzyl, indolyl or naphthyl wherein the phenyl, pyridyl, benzyl, indolyl and naphthyl is optionally substituted with 1, 2 or 3 R22; and the other variables are as defined in the claims, which are of use in the treatment of cancer, and related aspects.
    Type: Grant
    Filed: July 1, 2019
    Date of Patent: May 19, 2020
    Assignee: MEDIVIR AB
    Inventors: Richard Bethell, Anders Eneroth, Bjorn Klasson, Fredrik Oberg
  • DIOXOLANE ANALOGUES OF URIDINE FOR THE TREATMENT OF CANCER
    Publication number: 20190389890
    Abstract: The invention provides compounds of the formula: R1 is OR11, or NR5R5?; R2 is H or F; R5 is H, C1-C6alkyl, OH, C(?O)R6, O(C?O)R6 or O(C?O)OR6; R5? is H or C1-C6alkyl; R6 is C1-C6alkyl or C3-C7cycloalkyl; R13 is H, phenyl, pyridyl, benzyl, indolyl or naphthyl wherein the phenyl, pyridyl, benzyl, indolyl and naphthyl is optionally substituted with 1, 2 or 3 R22; and the other variables are as defined in the claims, which are of use in the treatment of cancer, and related aspects.
    Type: Application
    Filed: July 1, 2019
    Publication date: December 26, 2019
    Inventors: Richard BETHELL, Anders ENEROTH, Bjorn KLASSON, Fredrik OBERG
  • Dioxolane analogues of uridine for the treatment of cancer
    Patent number: 10336780
    Abstract: The invention provides compounds of the formula: R1 is OR11, or NR5R5?; R2 is H or F; R5 is H, C1-C6alkyl, OH, C(?O)R6, O(C?O)R6 or O(C?O)OR6; R5 is H or C1-C6alkyl; R6 is C1-C6alkyl or C3-C7cycloalkyl; R13 is H, phenyl, pyridyl, benzyl, indolyl or naphthyl wherein the phenyl, pyridyl, benzyl, indolyl and naphthyl is optionally substituted with 1, 2 or 3 R22; and the other variables are as defined in the claims, which are of use in the treatment of cancer, and related aspects.
    Type: Grant
    Filed: December 3, 2018
    Date of Patent: July 2, 2019
    Assignee: MEDIVIR AB
    Inventors: Richard Bethell, Anders Eneroth, Bjorn Klasson, Fredrik Oberg
  • DIOXOLANE ANALOGUES OF URIDINE FOR THE TREATMENT OF CANCER
    Publication number: 20190100541
    Abstract: The invention provides compounds of the formula: R1 is OR11, or NR5R5?; R2 is H or F; R5 is H, C1-C6alkyl, OH, C(?O)R6, O(C?O)R6 or O(OQ)OR6; R5? is H or C1-C6alkyl; R6 is C1-C6alkyl or C3-C7cloalkyl; R13 is H, phenyl, pyridyl, benzyl, indolyl or naphthyl wherein the phenyl, pyridyl, benzyl, indolyl and naphthyl is optionally substituted with 1, 2 or 3 R22; and the other variables are as defined in the claims, which are of use in the treatment of cancer, and related aspects.
    Type: Application
    Filed: December 3, 2018
    Publication date: April 4, 2019
    Inventors: Richard BETHELL, Anders ENEROTH, Bjorn KLASSON, Fredrik OBERG
  • Dioxolane analogues of cytidine for the treatment of cancer
    Patent number: 10144750
    Abstract: The invention provides compounds of the formula: R1 is OR11, or NR5R5?; R2 is H or F; R5 is H, OH, C1-C6 alkyl, OH, C(?O)R6, O(C?O)R6 or O(C?O)OR6; R5? is H or C1-C6 alkyl; R6 is C1-C6 alkyl or C3-C7 cycloalkyl; R13 is H, phenyl, pyridyl, benzyl, indolyl or naphthyl wherein the phenyl, pyridyl, benzyl, indolyl and naphthyl is optionally substituted with 1, 2 or 3 R22; and the other variables are as defined in the claims, which are of use in the treatment of cancer, and related aspects.
    Type: Grant
    Filed: August 24, 2015
    Date of Patent: December 4, 2018
    Assignee: MEDIVIR AB
    Inventors: Richard Bethell, Anders Eneroth, Bjorn Klasson, Fredrik Oberg
  • Process for manufacturing zeranol
    Patent number: 8674120
    Abstract: This invention is directed generally to a process for producing Zeranol that eliminates high pressure and high temperature hydrogenations and provides high selectivity for Zeranol at improved yields.
    Type: Grant
    Filed: November 3, 2009
    Date of Patent: March 18, 2014
    Assignee: Intervet International B.V.
    Inventors: John Richard Bethell, Gary Robert Reid, Krista Marie Affleck, Tibor Breining
  • Bicyclic nucleosides and nucleotides as therapeutic agents
    Patent number: 8501699
    Abstract: The present disclosure relates to the use and methods of manufacture of bicyclic nucleosides and nucleotides for the treatment and prevention of infectious and proliferative diseases, including microbial infections and cancer.
    Type: Grant
    Filed: September 7, 2012
    Date of Patent: August 6, 2013
    Assignee: Biota Scientific Management Pty Ltd
    Inventors: Paula Francom, Barbara Frey, Silas Bond, Alistair George Draffan, Michael Harding, Richard Hufton, Saba Hangiri, Michael John Lilly, Edward Tyndall, Jianmin Duan, Richard Bethell, George Kukolj
  • Bicyclic nucleosides and nucleotides as therapeutic agents
    Patent number: 8415309
    Abstract: The present disclosure relates to the use and methods of manufacture of bicyclic nucleosides and nucleotides for the treatment and prevention of infectious and proliferative diseases, including microbial infections and cancer.
    Type: Grant
    Filed: January 11, 2012
    Date of Patent: April 9, 2013
    Assignee: Biota Scientific Managment Pty Ltd
    Inventors: Paula Francom, Barbara Frey, Jianmin Duan, Richard Bethell, George Kukolj
  • BICYCLIC NUCLEOSIDES AND NUCLEOTIDES AS THERAPEUTIC AGENTS
    Publication number: 20130018013
    Abstract: The present disclosure relates to the use and methods of manufacture of bicyclic nucleosides and nucleotides for the treatment and prevention of infectious and proliferative diseases, including microbial infections and cancer.
    Type: Application
    Filed: September 7, 2012
    Publication date: January 17, 2013
    Applicant: BIOTA SCIENTIFIC MANAGEMENT PTY LTD
    Inventors: Paula Francom, Barbara Frey, Silas Bond, Alistair George Draffan, Michael Harding, Richard Hufton, Saba Jahangiri, Michael John Lilly, Edward Tyndall, Jianmin Duan, Richard Bethell, George Kukolj
  • BICYCLIC NUCLEOSIDES AND NUCLEOTIDES AS THERAPEUTIC AGENTS
    Publication number: 20120122811
    Abstract: The present disclosure relates to the use and methods of manufacture of bicyclic nucleosides and nucleotides for the treatment and prevention of infectious and proliferative diseases, including microbial infections and cancer.
    Type: Application
    Filed: January 11, 2012
    Publication date: May 17, 2012
    Applicant: Biota Scientific Management Pty Ltd
    Inventors: Paula Francom, Barbara Frey, Silas Bond, Jianmin Duan, Richard Bethell, George Kukolj
  • Bicyclic nucleosides and nucleotides as therapeutic agents
    Patent number: 8119607
    Abstract: The present disclosure relates to the use and methods of manufacture of bicyclic nucleosides and nucleotides for the treatment and prevention of infectious and proliferative diseases, including microbial infections and cancer.
    Type: Grant
    Filed: July 1, 2009
    Date of Patent: February 21, 2012
    Assignee: Biota Scientific Management Pty Ltd
    Inventors: Paula Francom, Barbara Frey, Silas Bond, Alistair George Draffan, Michael Harding, Richard Hufton, Saba Jahangiri, Michael John Lilly, Edward Tyndall, Jianmin Duan, Richard Bethell, George Kukolj
  • PROCESS FOR MANUFACTURING ZERANOL
    Publication number: 20120016137
    Abstract: This invention is directed generally to a process for producing Zeranol that eliminates high pressure and high temperature hydrogenations and provides high selectivity for Zeranol at improved yields.
    Type: Application
    Filed: November 3, 2009
    Publication date: January 19, 2012
    Inventors: John Richard Bethell, Gary Robert Reid, Krista Marie Affleck, Tibor Breining
  • BICYCLIC NUCLEOSIDES AND NUCLEOTIDES AS THERAPEUTIC AGENTS
    Publication number: 20100035836
    Abstract: The present disclosure relates to the use and methods of manufacture of bicyclic nucleosides and nucleotides for the treatment and prevention of infectious and proliferative diseases, including microbial infections and cancer.
    Type: Application
    Filed: July 1, 2009
    Publication date: February 11, 2010
    Inventors: Paula Francom, Barbara Frey, Silas Bond, Alistair George Draffan, Michael Harding, Richard Hufton, Saba Jahangiri, Michael John Lilly, Edward Tyndall, Jianmin Duan, Richard Bethell, George Kukolj
  • Process for detecting serine/threonine kinase activity
    Patent number: 7049080
    Abstract: The present invention describes a process for detecting threonine or serine kinase activity in an immunoassay using a pre-phosphorylated substrate.
    Type: Grant
    Filed: August 7, 2001
    Date of Patent: May 23, 2006
    Inventors: Joachim Kramer, Thomas Mander, Richard Bethell, Neil Benson, Helen Boyd, Pam Greengrass, Ross Kinloch