Patents by Inventor Richard Brent Pyles

Richard Brent Pyles has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Replication-competent herpes simplex virus
    Patent number: 6509020
    Abstract: A promising approach for the therapeutic treatment of brain tumors utilizes replication-competent, neuroattenuated herpes simplex virus-1 (HSV-1) mutants. This approach requires mutation of HSV-1 to eliminate killing of normal, non-dividing cells of the brain (e.g., neurons). The present invention discloses methods for killing malignant brain tumor cells in vivo entails providing replication competent herpes simplex virus vectors to tumor cells. A replication competent herpes simplex virus vector, with defective expression of the gamma 34.5 gene and the uracil DNA glycosylase (UNG) gene, specifically destroys tumor cells, is hypersensitive to anti-viral agents, and is not neurovirulent.
    Type: Grant
    Filed: September 22, 1999
    Date of Patent: January 21, 2003
    Assignee: The University of Cincinnati
    Inventors: Richard Brent Pyles, Linda Marie Parysek, Ronald E. Warnick