Abstract: Systems and methods of this disclosure make use of positive pressure to evacuate pipeline product contained within an isolated section of pipeline. In embodiments, an inert fluid is injected at a first location along the isolated section at a pressure above that of a non-isolated section of pipeline The displaced pipeline product, which may be filtered, then flows out of the isolated section at second location along the isolated section and into the non-isolated section. In other embodiments, a pressure differential between the isolated and non-isolated sections is created by lowering a pressure of the non-isolated section below that of the isolated section. The pipeline product may be a liquid, a gas, or a mixture of the two. The composition of product may be monitored as it flows through the isolated section or as it exits the section. Evacuation may be slowed or stopped based upon the composition.

Abstract: The disclosed embodiments disclose techniques for controlling a hybrid space-conditioning system (HSCS) that comprises a two-phase fluid circuit and an energy-exchange resource connected in parallel to the two-phase fluid circuit. During operation, a computing mechanism tracks operating characteristics for the system. The computing mechanism receives a temperature forecast and uses tracked characteristics and forecasts to predict watt usage for a subsequent time interval and a beneficial time interval during which the two-phase fluid circuit will operate with high efficiency. The computing mechanism charges the energy-exchange resource during the beneficial time interval, and then reduces the watt usage of the HSCS by leveraging the charged energy-exchange resource during a time interval in which the two-phase fluid circuit is predicted to operate inefficiently.

Abstract: The disclosed embodiments disclose techniques for controlling a hybrid space-conditioning system (HSCS) that comprises a two-phase fluid circuit and an energy-exchange resource connected in parallel to the two-phase fluid circuit. During operation, a computing mechanism tracks operating characteristics for the system. The computing mechanism receives a temperature forecast and uses tracked characteristics and forecasts to predict watt usage for a subsequent time interval and a beneficial time interval during which the two-phase fluid circuit will operate with high efficiency. The computing mechanism charges the energy-exchange resource during the beneficial time interval, and then reduces the watt usage of the HSCS by leveraging the charged energy-exchange resource during a time interval in which the two-phase fluid circuit is predicted to operate inefficiently.

Abstract: Systems and methods of this disclosure make use of positive pressure to evacuate pipeline product contained within an isolated section of pipeline. In embodiments, an inert fluid is injected at a first location along the isolated section at a pressure above that of a non-isolated section of pipeline The displaced pipeline product, which may be filtered, then flows out of the isolated section at second location along the isolated section and into the non-isolated section. In other embodiments, a pressure differential between the isolated and non-isolated sections is created by lowering a pressure of the non-isolated section below that of the isolated section. The pipeline product may be a liquid, a gas, or a mixture of the two. The composition of product may be monitored as it flows through the isolated section or as it exits the section. Evacuation may be slowed or stopped based upon the composition.

Abstract: Provided include compositions, methods, and systems for modulating the expression, function, and/or activity of a target gene, for example a blood-clotting protein such as Factor VIII (FVIII), in a cell by genome editing. Also provided include compositions, methods, and systems for treating a subject having or suspected of having a disorder or health condition, e.g., Hemophilia A, employing ex vivo and/or in vivo genome editing.

Abstract: A water producing system for a photovoltaic panel may include a moisture collection layer, a liquid transfer mat, and a moisture collection substrate. The moisture collection layer may collect moisture from condensation and direct moisture away from the photovoltaic panel. The liquid transfer mat may include a plurality of tubes through which a chilled heat transfer liquid passes. The moisture collection substrate may include a thermally conductive material. The chilled heat transfer liquid within the liquid transfer mat may absorb heat from the photovoltaic panel and from ambient air through the moisture collection substrate, thereby reducing a temperature of the photovoltaic panel and condensing water on the moisture collection substrate to produce water.

Abstract: A waste heat recovery system for a photovoltaic panel may include an open loop system and a closed loop system. The open loop system includes an electric insulator layer and a moisture collection layer. The moisture collection layer may collect moisture from condensation and to direct moisture away from the photovoltaic panel. The closed loop system may be positioned adjacent to the open loop system. The closed loop system may include a liquid transfer mat that has a plurality of tubes through which a liquid passes to absorb heat from the photovoltaic panel. The open loop system is configured to encourage heat transfer from the photovoltaic panel to the closed loop system.

Abstract: Provided include compositions, methods, and systems for modulating the expression, function, and/or activity of a target gene, for example a blood-clotting protein such as Factor VIII (FVIII), in a cell by genome editing. Also provided include compositions, methods, and systems for treating a subject having or suspected of having a disorder or health condition, e.g., Hemophilia A, employing ex vivo and/or in vivo genome editing.

Abstract: Provided herein, in some embodiments, are materials and methods for treating hemophilia A in a subject ex vivo or in vivo. Also provided herein, in some embodiments, are materials and methods for knocking in a coding sequence encoding a synthetic FVIII having a B domain substitute into a genome.

Abstract: A control system for use with a working machine includes a machine body, and a load handling apparatus coupled to the machine body and moveable by a movement actuator with respect to the machine body, with the working machine being configured for use with at least one electric energy storage module. The control system includes a controller configured to: receive or acquire information representative of an attribute of said electric energy storage module; determine permitted and/or prohibited operations of the working machine based on the received or acquired information; and issue an operations signal for use by at least one element of the working machine corresponding to the determined permitted and/or prohibited operations.

Abstract: Provided herein, in some embodiments, are materials and methods for treating hemophilia A in a subject ex vivo or in vivo. Also provided herein, in some embodiments, are materials and methods for knocking in a coding sequence encoding a synthetic FVIII having a B domain substitute into a genome.

Abstract: A control system for use with a working machine is provided, the working machine including a machine body, and a load handling apparatus coupled to the machine body and moveable by a movement actuator with respect to the machine body, the working machine being configured for use with at least one electric energy storage module. The control system includes a controller configured to: receive or acquire information representative of an attribute of said electric energy storage module; determine permitted and/or prohibited operations of the working machine based on the received or acquired information; and issue an operations signal for use by at least one element of the working machine corresponding to the determined permitted and/or prohibited operations.

Abstract: Provided include materials and methods for treating Hemophilia A in a subject ex vivo or in vivo. Also provided include materials and methods for knocking in a FVIII-encoding gene in a genome, in particular the locus of albumin gene.

Abstract: A blind cutting machine includes a cutting blade; a base disposed on a first side of the cutting blade; and a guide disposed on a second side of the cutting blade. The first side is opposite the second side. The guide is adjacent to the cutting blade. The guide is configured to direct cutoff material to a waste collection area. An assembly includes a first member that is rotatable. A second member is configured to limit an amount of rotation of the first member. An actuator is configured to move the second member to a location wherein the second member does not limit the amount of rotation of the first member. The first member is configured to prevent a hand of an operator from coming into contact with the cutting blade.

Abstract: An IOT mesh system for smart cities is disclosed, the system comprising at least one primary module and a plurality of secondary modules suitable for on-street use. The secondary modules are configured to communicate with each other and with the at least one primary module using a wireless mesh communications protocol. The at least one primary module is configured to communicate with a control server using a low power wide area network, LEW AN, communications protocol. In particular examples, one or more of the modules are vehicle sensors.

Abstract: A working machine including a machine body having an operator cab, a ground engaging propulsion structure to permit movement of the machine over the ground, a load handling apparatus coupled to the machine body and moveable by a movement actuator with respect to the machine body, and an electric energy storage unit for providing power to the working machine. The working machine includes a longitudinal axis, wherein the operator cab is positioned towards a first side of the working machine with respect to the longitudinal axis, and the electric energy storage unit is positioned towards a second side of the working machine with respect to the longitudinal axis, wherein the first and second sides are located opposite each other.

Abstract: A working machine including a machine body having an operator cab, a ground engaging propulsion structure to permit movement of the machine over the ground, a load handling apparatus coupled to the machine body and moveable by a movement actuator with respect to the machine body, and an electric energy storage unit for providing power to the working machine. The working machine includes a longitudinal axis, wherein the operator cab is positioned towards a first side of the working machine with respect to the longitudinal axis, and the electric energy storage unit is positioned towards a second side of the working machine with respect to the longitudinal axis, wherein the first and second sides are located opposite each other.

Abstract: Aiming assistance is provided for assisting a user in aiming a ranged weapon at a target. The aiming assistance includes receiving telemetry information from one or more sensors, and determining an aim error based on the telemetry information. The aim error indicates of an error between a trajectory of the ranged weapon and an on target trajectory from the ranged weapon to the target. A somatosensation is provided to the user which is indicative of the aim error. This is done by operating haptic devices of a garment worn on an arm or wrist of the user to apply haptic sensation to skin of the arm or wrist. The haptic devices may be electrodes and the applied haptic sensation comprises transcutaneous electrical neurostimulation (TENS), or the haptic devices may be vibrators.

Abstract: A water producing system for a photovoltaic panel may include a moisture collection layer, a liquid transfer mat, and a moisture collection substrate. The moisture collection layer may collect moisture from condensation and direct moisture away from the photovoltaic panel. The liquid transfer mat may include a plurality of tubes through which a chilled heat transfer liquid passes. The moisture collection substrate may include a thermally conductive material. The chilled heat transfer liquid within the liquid transfer mat may absorb heat from the photovoltaic panel and from ambient air through the moisture collection substrate, thereby reducing a temperature of the photovoltaic panel and condensing water on the moisture collection substrate to produce water.

Abstract: Provided herein, in some embodiments, are materials and methods for treating hemophilia A in a subject ex vivo or in vivo. Also provided herein, in some embodiments, are materials and methods for knocking in a coding sequence encoding a synthetic FVIII having a B domain substitute into a genome.