Patents by Inventor RICHARD BRUEHL

RICHARD BRUEHL has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Recombinant Deamidated Gliadin Antigen
    Publication number: 20170146531
    Abstract: The present invention provides a method for determining whether a subject is suffering from celiac disease by contacting a sample of bodily fluid from the subject, with an antigen formed from a gliadin fusion protein immobilized on a solid support. The gliadin fusion protein of the antigen includes a recombinant deamidated gliadin linked to a tag such as Glutathione-S transferase (GST) protein. The antigen is prepared by immobilizing on the solid support the gliadin fusion protein via the tag. The antigen can further include tissue Transglutaminase (tTG) cross-linked to the gliadin fusion protein. When tTG is present, the tTG and recombinant deamidated gliadin are mixed together prior to immobilization to the solid phase.
    Type: Application
    Filed: January 20, 2017
    Publication date: May 25, 2017
    Inventors: Michael I. Watkins, Gregory A. Marr, Xiaoyun Yang, Richard Bruehl, Daming Shan, Patrick F. Coleman
  • RECOMBINANT DEAMIDATED GLIADIN ANTIGEN
    Publication number: 20090311727
    Abstract: The present invention provides a method for determining whether a subject is suffering from celiac disease by contacting a sample of bodily fluid from the subject, with an antigen formed from a gliadin fusion protein immobilized on a solid support. The gliadin fusion protein of the antigen includes a recombinant deamidated gliadin linked to a tag such as Glutathione-S transferase (GST) protein. The antigen is prepared by immobilizing on the solid support the gliadin fusion protein via the tag. The antigen can further include tissue Transglutaminase (tTG) cross-linked to the gliadin fusion protein. When tTG is present, the tTG and recombinant deamidated gliadin are mixed together prior to immobilization to the solid phase.
    Type: Application
    Filed: April 17, 2009
    Publication date: December 17, 2009
    Applicant: BIO-RAD LABORATORIES, INC.
    Inventors: MICHAEL I. WATKINS, GREGORY A. MARR, XIAOYUN YANG, RICHARD BRUEHL, DAMING SHAN, PATRICK F. COLEMAN