Abstract: A machine-learning based method includes receiving an instruction to model an engagement predicting score for a user. User-specific, activity-specific data is obtained from digital resources that include a user-specific activity performance data regarding performance of at least one activity by the user, an object data for an object that allows the user to perform the at least one activity, and user-specific personal data of the user. A user-specific activity engagement labeling data for the at least one activity is predicted by utilizing a first-type data pipeline on the at least one user-specific activity performance data. User-specific, activity-specific data features are predicted by utilizing a second-type data pipeline on the user-specific, activity-specific data. The engagement predicting score is predicted from the user-specific, activity-specific data features and the user-specific activity engagement labeling data.

Abstract: A machine-learning based method includes receiving an instruction to model an engagement predicting score for a user. User-specific, activity-specific data is obtained from digital resources that include a user-specific activity performance data regarding performance of at least one activity by the user, an object data for an object that allows the user to perform the at least one activity, and user-specific personal data of the user. A user-specific activity engagement labeling data for the at least one activity is predicted by utilizing a first-type data pipeline on the at least one user-specific activity performance data. User-specific, activity-specific data features are predicted by utilizing a second-type data pipeline on the user-specific, activity-specific data. The engagement predicting score is predicted from the user-specific, activity-specific data features and the user-specific activity engagement labeling data.

Abstract: A method of treating prostate cancer in a patient comprising administering to the patient a pharmaceutical composition including a first therapeutic including a TLK1B inhibitor, or a pharmaceutically acceptable salt, solvate, ester, amide, clathrate, stereoisomer, enantiomer, prodrug or analog thereof, and a second therapeutic including an antiandrogen or a pharmaceutically acceptable salt, solvate, ester, amide, clathrate, stereoisomer, enantiomer, prodrug or analog thereof.

Abstract: Methods and apparatus for a fastener head having a dual zone socket area and a mating driver bit according to aspects of the present technology include a fastener configured with driving surfaces adapted to provide enhanced engagement between each other during use. The fastener includes a recessed socket area with a sidewall that has an upper inwardly tapering section and a lower vertical section that extends to the bottom of the recessed socket area. The upper inwardly tapering section of the sidewall may also include an offset relative to the lower vertical section to create asymmetrical driving and removal surfaces. The technology also includes a corresponding mating driver bit configured with mating surfaces to the fastener to provide enhanced engagement between the fastener and mating driver bit. The technology also allows either the fastener or the driving bit to be used with preexisting fasteners and driver bits.

Abstract: A method of treating prostate cancer in a patient comprising administering to the patient a pharmaceutical composition including a first therapeutic including a TLK1B inhibitor, or a pharmaceutically acceptable salt, solvate, ester, amide, clathrate, stereoisomer, enantiomer, prodrug or analog thereof, and a second therapeutic including an antiandrogen or a pharmaceutically acceptable salt, solvate, ester, amide, clathrate, stereoisomer, enantiomer, prodrug or analog thereof.

Abstract: Methods and apparatus for a fastener head having a dual zone socket area and a mating driver bit according to aspects of the present technology include a fastener configured with driving surfaces adapted to provide enhanced engagement between each other during use. The fastener includes a recessed socket area with a sidewall that has an upper inwardly tapering section and a lower vertical section that extends to the bottom of the recessed socket area. The upper inwardly tapering section of the sidewall may also include an offset relative to the lower vertical section to create asymmetrical driving and removal surfaces. The technology also includes a corresponding mating driver bit configured with mating surfaces to the fastener to provide enhanced engagement between the fastener and mating driver bit. The technology also allows either the fastener or the driving bit to be used with preexisting fasteners and driver bits.

Abstract: A machine-learning based method includes receiving an instruction to model an engagement predicting score for a user. User-specific, activity-specific data is obtained from digital resources that include a user-specific activity performance data regarding performance of at least one activity by the user, an object data for an object that allows the user to perform the at least one activity, and user-specific personal data of the user. A user-specific activity engagement labeling data for the at least one activity is predicted by utilizing a first-type data pipeline on the at least one user-specific activity performance data. User-specific, activity-specific data features are predicted by utilizing a second-type data pipeline on the user-specific, activity-specific data. The engagement predicting score is predicted from the user-specific, activity-specific data features and the user-specific activity engagement labeling data.

Abstract: A machine-learning based method includes receiving an instruction to model an engagement predicting score for a user. User-specific, activity-specific data is obtained from digital resources that include a user-specific activity performance data regarding performance of at least one activity by the user, an object data for an object that allows the user to perform the at least one activity, and user-specific personal data of the user. A user-specific activity engagement labeling data for the at least one activity is predicted by utilizing a first-type data pipeline on the at least one user-specific activity performance data. User-specific, activity-specific data features are predicted by utilizing a second-type data pipeline on the user-specific, activity-specific data. The engagement predicting score is predicted from the user-specific, activity-specific data features and the user-specific activity engagement labeling data.

Abstract: Methods and apparatus for a fastener head having a dual zone socket area and a mating driver bit according to aspects of the present technology include a fastener configured with driving surfaces adapted to provide enhanced engagement between each other during use. The fastener includes a recessed socket area with a sidewall that has an upper inwardly tapering section and a lower vertical section that extends to the bottom of the recessed socket area. The upper inwardly tapering section of the sidewall may also include an offset relative to the lower vertical section to create asymmetrical driving and removal surfaces. The technology also includes a corresponding mating driver bit configured with mating surfaces to the fastener to provide enhanced engagement between the fastener and mating driver bit. The technology also allows either the fastener or the driving bit to be used with preexisting fasteners and driver bits.

Abstract: Methods and apparatus for a fastener head having a dual zone socket area and a mating driver bit according to aspects of the present technology include a fastener configured with driving surfaces adapted to provide enhanced engagement between each other during use. The fastener includes a recessed socket area with a sidewall that has an upper inwardly tapering section and a lower vertical section that extends to the bottom of the recessed socket area. The upper inwardly tapering section of the sidewall may also include an offset relative to the lower vertical section to create asymmetrical driving and removal surfaces. The technology also includes a corresponding mating driver bit configured with mating surfaces to the fastener to provide enhanced engagement between the fastener and mating driver bit. The technology also allows either the fastener or the driving bit to be used with preexisting fasteners and driver bits.

Abstract: Methods and apparatus for a fastener head having a dual zone socket area and a mating driver bit according to aspects of the present technology include a fastener configured with driving surfaces adapted to provide enhanced engagement between each other during use. The fastener includes a recessed socket area with a sidewall that has an upper inwardly tapering section and a lower vertical section that extends to the bottom of the recessed socket area. The upper inwardly tapering section of the sidewall may also include an offset relative to the lower vertical section to create asymmetrical driving and removal surfaces. The technology also includes a corresponding mating driver bit configured with mating surfaces to the fastener to provide enhanced engagement between the fastener and mating driver bit. The technology also allows either the fastener or the driving bit to be used with preexisting fasteners and driver bits.

Abstract: A spirit level comprising a generally central elongate bar (1), and at least one pair of arm members (6) pivotally coupled at a respective end of said bar for movement between a first, extended, generally H-shaped configuration in which said arm members (6) extend from said end of side bar at an angle thereto, and a second folded configuration, in which a side-wall of each of said arm members (6) is substantially parallel to and located against or adjacent to a side edge of said central bar, wherein at least one bulb (2) containing a bubble is provided in or on said central bar (1) and oriented substantially parallel to its longitudinal axis, and at least one bulb (2) containing a bubble is provided in or on an arm member (6) and oriented substantially parallel to its longitudinal axis.

Abstract: A method of treating prostate cancer in a patient comprising administering to the patient a pharmaceutical composition including a first therapeutic including a TLK1B inhibitor, or a pharmaceutically acceptable salt, solvate, ester, amide, clathrate, stereoisomer, enantiomer, prodrug or analog thereof, and a second therapeutic including an antiandrogen or a pharmaceutically acceptable salt, solvate, ester, amide, clathrate, stereoisomer, enantiomer, prodrug or analog thereof.

Abstract: Methods and apparatus for a fastener head having a dual zone socket area and a mating driver bit according to aspects of the present technology include a fastener configured with driving surfaces adapted to provide enhanced engagement between each other during use. The fastener includes a recessed socket area with a sidewall that has an upper inwardly tapering section and a lower vertical section that extends to the bottom of the recessed socket area. The upper inwardly tapering section of the sidewall may also include an offset relative to the lower vertical section to create asymmetrical driving and removal surfaces. The technology also includes a corresponding mating driver bit configured with mating surfaces to the fastener to provide enhanced engagement between the fastener and mating driver bit. The technology also allows either the fastener or the driving bit to be used with preexisting fasteners and driver bits.

Abstract: An environmental control system (ECS) having contaminants in supply air that flows into an environment includes an outside air contaminant component that senses contaminants in outside air, wherein the outside air contaminant component is upstream of the environment, A recirculated air contaminant component is provided and that senses contaminants in recirculated air supplied by the environment, wherein the recirculated air contaminant component is downstream of the environment. A voltage supply provides a non-linear variable voltage to at least one of the components. A controller is in communication with the components and the voltage supply; wherein, upon a measured resistance, from at least one of the components, that exceeds a threshold, the controller varies at least one of an outside air flow and a recirculated air flow in the ECS.

Abstract: A spirit level comprising a generally central elongate bar (1), and at least one pair of arm members (6) pivotally coupled at a respective end of said bar for movement between a first, extended, generally H-shaped configuration in which said arm members (6) extend from said end of side bar at an angle thereto, and a second folded configuration, in which a side-wall of each of said arm members (6) is substantially parallel to and located against or adjacent to a side edge of said central bar, wherein at least one bulb (2) containing a bubble is provided in or on said central bar (1) and oriented substantially parallel to its longitudinal axis, and at least one bulb (2) containing a bubble is provided in or on an arm member (6) and oriented substantially parallel to its longitudinal axis.

Abstract: An environmental control system (ECS) having contaminants in supply air that flows into an environment includes an outside air contaminant component that senses contaminants in outside air, wherein the outside air contaminant component is upstream of the environment, A recirculated air contaminant component is provided and that senses contaminants in recirculated air supplied by the environment, wherein the recirculated air contaminant component is downstream of the environment. A voltage supply provides a non-linear variable voltage to at least one of the components. A controller is in communication with the components and the voltage supply; wherein, upon a measured resistance, from at least one of the components, that exceeds a threshold, the controller varies at least one of an outside air flow and a recirculated air flow in the ECS.

Abstract: Methods and apparatus for an enhanced driving bit according to various aspects of the present technology include a bit comprising a plurality of driving surfaces having a limited length and a shoulder portion positioned between the driving surfaces and a mid-body portion of the bit. The length of the driving surfaces is selected to allow complete insertion into a recessed socket area of a fastener such that the entire driving surface is positioned within the recessed socket area. The shoulder surface is configured to distribute localized stresses away from the driving surfaces to the mid-body portion more efficiently to reduce a potential for breakage of the driving surfaces during use.