Abstract: A system and method for performing structural health monitoring on a structural element while it remains in service and experiences normal loading. The energy input to the element will be the normal and random energy inputs the element sees in service. The inventive system places an intelligent module at one or more points along the length of the structural element. The inventive system collects mass data from multiple modules on multiple elements. The system then applies machine learning or artificial intelligence techniques to detect changes in the measurements received from one or more modules. This approach reduces or eliminates the need to provide calibrated input energy. The invention preferably provides the ability to determine the condition of one element or sub-element under measurement relative to other elements.

Abstract: This invention related to compounds that are inhibitors of the CDK12 kinase. The compounds are useful in the treatment of disorders mediated by the CDK12 kinase including myotonic dystrophy type 1 (DM1) and other disorders caused by the generation of RNA repeat expansion transcripts. In particular, the invention relates to compounds of the formula (I), or a pharmaceutically acceptable salts or N-oxides thereof, wherein R1a, R2, R3, R4a, R4b and R4c are as defined herein.

Abstract: This invention related to compounds that are inhibitors of the CDK12 kinase. The compounds are useful in the treatment of disorders mediated by the CDK12 kinase including myotonic dystrophy type 1 (DM1) and other disorders caused by the generation of RNA repeat expansion transcripts. In particular, the invention relates to compounds of the formula (I), or a pharmaceutically acceptable salts or N-oxides thereof, wherein R1a, R2, R3, R4a, R4b and R4c are as defined herein.

Abstract: The invention provides [2-(4-chloro-benzyloxy)-ethyl]-[2-((R)-cyclohexyl-hydroxy-phenyl-methyl)-oxazol-5-yl-methyl]-dimethyl-ammonium napadisylate, pharmaceutical compositions containing it, and its use in therapy.

Abstract: The present invention pertains to a method of combating fruit flies by bringing into contact the male and the female species with fipronil characterized in that a) the male species are lured onto a material containing a pheromone or a parapheromone and fipronil b) the male species take up fipronil via contact with this material and c) transfer fipronil to the females via contact. The present invention also pertains to a method of combating fruit flies by bringing into contact the female species with fipronil according to the above-defined method. The present invention further provides a method of substantially eradicating from a land area fruit flies comprising the above method.

Abstract: A compound of formula (I): which can be used in the treatment of diseases associated with histone deacetylase enzymatic activity.