Patents by Inventor Richard C. Border

Richard C. Border has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cationic lipids for intracellular delivery of biologically active molecules
    Patent number: 5459127
    Abstract: Disclosed are cationic lipids capable of facilitating transport of biologically active agents into cells, including the transfection of cells by therapeutic polynucleotides, the delivery of antiviral drugs, and the introduction of immunogenic peptides. The cationic lipids, comprising an ammonium group, have the general structure ##STR1## Also disclosed are adducts of these compounds comprising additional cationic sites that enhance the transfective or transport activity. Structure-activity correlations provide for the selection of preferred compounds to be synthesized for this purpose. Compositions disclosed for use of these cationic lipid include formulations for in vitro transfection and pharmaceutical formulations for parenteral and topical administration of therapeutic agents.
    Type: Grant
    Filed: September 16, 1993
    Date of Patent: October 17, 1995
    Assignee: Vical, Inc.
    Inventors: Philip L. Felgner, Raj Kumar, Channa Basava, Richard C. Border, Jiin-Yu Hwang-Felgner
  • Cationic lipids for intracellular delivery of biologically active molecules
    Patent number: 5264618
    Abstract: Disclosed are cationic lipids capable of facilitating transport of biologically active agents into cells, including the transfection of cells by therapeutic polynucleotides, the delivery of antiviral drugs, and the introduction of immunogenic peptides. The cationic lipids, comprising an ammonium group, have the general structure ##STR1## Also disclosed are adducts of these compounds comprising additional cationic sites that enhance the transfective or transport activity. Structure-activity correlations provide for the selection of preferred compounds to be synthesized for this purpose. Compositions disclosed for use of these cationic lipid include formulations for in vitro transfection and pharmaceutical formulations for parenteral and topical administration of therapeutic agents.
    Type: Grant
    Filed: April 16, 1991
    Date of Patent: November 23, 1993
    Assignee: Vical, Inc.
    Inventors: Philip L. Felgner, Raj Kumar, Channa Basava, Richard C. Border, Jiin-Yu Hwang-Felgner