Patents by Inventor Richard C. Conrad

Richard C. Conrad has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modified surfaces as solid supports for nucleic acid purification
    Patent number: 8426126
    Abstract: The invention relates to methods of separating polynucleotides, such as DNA, RNA and PNA, from solutions containing polynucleotides by reversibly binding the polynucleotides to a solid surface, such as a magnetic microparticle.
    Type: Grant
    Filed: September 30, 2004
    Date of Patent: April 23, 2013
    Assignee: Applied Biosystems, LLC
    Inventors: Gary J. Latham, Xingwang Fang, Richard C. Conrad, Jon A. Kemppainen, Robert A. Setterquist, Brittan L. Pasloske
  • Methods and compositions for isolating small RNA molecules
    Patent number: 8404439
    Abstract: The present invention concerns the use of methods and compositions for the isolation of small RNA molecules (100 nucleotides or fewer), such as microRNA and siRNA molecules. Such molecules are routinely lost in commonly used isolation procedures and therefore the present invention allows for a much higher level of enrichment or isolation of these small RNA molecules.
    Type: Grant
    Filed: November 2, 2009
    Date of Patent: March 26, 2013
    Assignee: Applied Biosystems, LLC
    Inventor: Richard C. Conrad
  • COMPOSITIONS AND METHODS FOR PRESERVING RNA IN BIOLOGICAL SAMPLES
    Publication number: 20120305846
    Abstract: The present invention concerns methods and compositions to prepare biological samples to preserve the macromolecules in the samples. Embodiments of the invention concern the use of a soak solution that contains one or more water-miscible solvents. A sample is incubated with the soak solution to the point of saturation at a temperature above the melting temperature of the water-miscible solvent but below 0° C. The use of methods and compositions of the invention allow for subsequent preparation or analysis of the samples.
    Type: Application
    Filed: May 3, 2012
    Publication date: December 6, 2012
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Matthew M. WINKLER, Richard C. CONRAD
  • Compositions and methods for preserving RNA in biological samples
    Patent number: 8193001
    Abstract: The present invention concerns methods and compositions to prepare biological samples to preserve the macromolecules in the samples. Embodiments of the invention concern the use of a soak solution that contains one or more water-miscible solvents. A sample is incubated with the soak solution to the point of saturation at a temperature above the melting temperature of the water-miscible solvent but below 0° C. The use of methods and compositions of the invention allow for subsequent preparation or analysis of the samples.
    Type: Grant
    Filed: February 23, 2009
    Date of Patent: June 5, 2012
    Assignee: Applied Biosystems, LLC
    Inventors: Matthew M. Winkler, Richard C. Conrad
  • METHODS AND COMPOSITIONS FOR ISOLATING SMALL RNA MOLECULES
    Publication number: 20100222564
    Abstract: The present invention concerns the use of methods and compositions for the isolation of small RNA molecules (100 nucleotides or fewer), such as microRNA and siRNA molecules. Such molecules are routinely lost in commonly used isolation procedures and therefore the present invention allows for a much higher level of enrichment or isolation of these small RNA molecules.
    Type: Application
    Filed: November 2, 2009
    Publication date: September 2, 2010
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventor: Richard C. Conrad
  • COMPOSITIONS AND METHODS FOR PRESERVING RNA IN BIOLOGICAL SAMPLES
    Publication number: 20090197346
    Abstract: The present invention concerns methods and compositions to prepare biological samples to preserve the macromolecules in the samples. Embodiments of the invention concern the use of a soak solution that contains one or more water-miscible solvents. A sample is incubated with the soak solution to the point of saturation at a temperature above the melting temperature of the water-miscible solvent but below 0° C. The use of methods and compositions of the invention allow for subsequent preparation or analysis of the samples.
    Type: Application
    Filed: February 23, 2009
    Publication date: August 6, 2009
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Matthew M. Winkler, Richard C. Conrad
  • Compositions and methods for preserving RNA in biological samples
    Patent number: 7517697
    Abstract: The present invention concerns methods and compositions to prepare biological samples to preserve the macromolecules in the samples. Embodiments of the invention concern the use of a soak solution that contains one or more water-miscible solvents. A sample is incubated with the soak solution to the point of saturation at a temperature above the melting temperature of the water-miscible solvent but below 0° C. The use of methods and compositions of the invention allow for subsequent preparation or analysis of the samples.
    Type: Grant
    Filed: February 5, 2003
    Date of Patent: April 14, 2009
    Assignee: Applied Biosystems, LLC
    Inventors: Matthew M. Winkler, Richard C. Conrad
  • HIGH EFFICIENCY MRNA ISOLATION METHODS AND COMPOSITIONS
    Publication number: 20040230048
    Abstract: The present invention provides methods and compositions, including kits, for the isolation and purification of mRNA, particularly poly(A) RNA. It concerns the use of isostabilizing salts such as TMAC and TEAC to reduce rRNA carryover during the purification process, thus facilitating the isolation of poly(A) RNA.
    Type: Application
    Filed: May 11, 2001
    Publication date: November 18, 2004
    Applicant: AMBION, INC.
    Inventor: Richard C. Conrad
  • High efficiency mRNA isolation methods and compositions
    Patent number: 6812341
    Abstract: The present invention provides methods and compositions, including kits, for the isolation and purification of mRNA, particularly poly(A) RNA. It concerns the use of isostabilizing salts such as TMAC and TEAC to reduce rRNA carryover during the purification process, thus facilitating the isolation of poly(A) RNA.
    Type: Grant
    Filed: May 11, 2001
    Date of Patent: November 2, 2004
    Assignee: Ambion, Inc.
    Inventor: Richard C. Conrad