Patents by Inventor Richard C. Dage

Richard C. Dage has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of using quinolyloxazole-2-ones as proteinkinase C inhibitors
    Patent number: 4990519
    Abstract: This invention relates to novel quinolyloxazole-2-ones which are useful as protein kinase C inhibitors, effective in the treatment of hypertension and asthma. This invention also includes a novel procedure for producing an intermediate ketone compound involving the reaction of a bromo-quinoline compound with butyl lithium and further reacting the lithiated compound with N-methyl-N-methoxyalkanamide.
    Type: Grant
    Filed: February 23, 1990
    Date of Patent: February 5, 1991
    Assignee: Merrell Dow Pharmaceuticals
    Inventors: Winton D. Jones, George P. Claxton, Richard C. Dage, Hsien C. Cheng, Phillip J. Robinson
  • Cardiotonic aroylthiazolones
    Patent number: 4927939
    Abstract: Aroylthiazolones enhance myocardial contractile force and are useful as cardiotonics in the treatment of heart failure.
    Type: Grant
    Filed: March 17, 1987
    Date of Patent: May 22, 1990
    Assignee: Merrell Dow Pharmaceuticals
    Inventors: J. Martin Grisar, Richard C. Dage, Richard A. Schnettler
  • Novel alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones
    Patent number: 4920229
    Abstract: This invention relates to alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones and to their use as cardiotonic agents useful in treating cardiac failure, and to the process useful in the preparation thereof.
    Type: Grant
    Filed: March 10, 1989
    Date of Patent: April 24, 1990
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Winton D. Jones, Richard C. Dage, Richard A. Schnettler
  • Qunolyloxazole-2-ones useful as proteinkinase C inhibitors
    Patent number: 4886811
    Abstract: This invention relates to novel quinolyloxazole-2-ones which are useful as protein kinase C inhibitors, effective in the treatment of hypertension and asthma. This invention also includes a novel procedure for producing an intermediate ketone compound involving the reaction of a bromo-quinoline compound with butyl lithium and further reacting the lithiated compound with N-methyl-N-methoxyalkanamide.
    Type: Grant
    Filed: October 24, 1988
    Date of Patent: December 12, 1989
    Assignee: Merrell Dow Pharmaceuticals
    Inventors: Winton D. Jones, George P. Claxton, Richard C. Dage, Hsien C. Cheng, Phillip J. Robinson
  • Imidazole antiarrhythmics
    Patent number: 4868194
    Abstract: The present invention is directed to a new class of piperidinyl imidazole antiarrhythmic agents and to methods for treating arrhythmias.
    Type: Grant
    Filed: September 23, 1988
    Date of Patent: September 19, 1989
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Albert A. Carr, John E. Koerner, Richard C. Dage, Tung Li, David A. Hay
  • Enhancement of prazosin
    Patent number: 4868182
    Abstract: This invention relates to the synergistic enhancement of certain antihypertensives by the conjunctive use of certain cardiotonic agents. More specifically, this invention relates to the enhancement of the blood pressure lowering effect achieved with alpha.sub.1 -adrenoceptor antagonists by the conjunctive administration of cardiotonic agents possessing the ability to specifically inhibit cyclic AMP-phosphodiesterase.
    Type: Grant
    Filed: February 3, 1988
    Date of Patent: September 19, 1989
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventor: Richard C. Dage
  • Reducing reperfusion injury with 1,3-dihydro-4-methyl-5-(4-methylthio)benzoyl)-2H-imidazol-2-thione
    Patent number: 4868197
    Abstract: A sulfur analog of enoximone, 1,3-dihydro-4-methyl-5-[4-(methylthio)benzoyl]-2H-imidazol-2-thione, is reported to reduce reperfusion injury, the injry which occurs when molecular oxygen is reintroduced into an ischemic tissue. The compound could be used to prevent much of the damage which occurs to the heart of a heart attack victim.
    Type: Grant
    Filed: March 21, 1988
    Date of Patent: September 19, 1989
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Richard A. Schnettler, Richard C. Dage, J. Martin Grisar, Frank P. Palopoli
  • Cardiotonic alkanoyl and aroyl oxazolones
    Patent number: 4866182
    Abstract: Alkanoyl or aroyl oxazolones enhance myocardial contractile force and are useful as cardiotonics in the treatment of heart failure.
    Type: Grant
    Filed: February 18, 1988
    Date of Patent: September 12, 1989
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Richard A. Schnettler, Winton D. Jones, Richard C. Dage
  • Certain 3-carboxylate or 3-carbamyl-5-acyl-2-(1H)-pyridinones having cardiotonic properties
    Patent number: 4853395
    Abstract: Novel 5-acyl-2-(1H)pyridinones and their use as cardiotonic agents. Typical of the compounds is 5-acetyl-1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile which is prepared by condensing anionic cyano acetamide with 3-[(dimethylamino)methylenyl]-2,4-pentanedione in an inert organic solvent.
    Type: Grant
    Filed: November 17, 1987
    Date of Patent: August 1, 1989
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Winton D. Jones, Richard A. Schnettler, Richard C. Dage
  • Novel alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones
    Patent number: 4849522
    Abstract: This invention relates to alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones and to their use as cardiotonic agents useful in treating cardiac failure, and to the process useful in the preparation thereof.
    Type: Grant
    Filed: March 10, 1988
    Date of Patent: July 18, 1989
    Assignee: Merrell Dow Pharmaceuticals
    Inventors: Winton D. Jones, Richard C. Dage, Richard A. Schnettler
  • Cardiotonic tricyclic oxazolones
    Patent number: 4803210
    Abstract: Tricyclic oxazolones enhance myocardial contractile force and are useful as cardiotonics in the treatment of heart failure.
    Type: Grant
    Filed: April 14, 1988
    Date of Patent: February 7, 1989
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Winton D. Jones, Richard A. Schnettler, George P. Claxton, Richard C. Dage
  • 2H-[1]benzoxepino[5,4-b]-1,4-oxazine derivatives
    Patent number: 4766212
    Abstract: Derivatives of 2H-[1]benzoxepino[5,4-b]-1,4-oxazine, such as trans-3,4,4a,5,6,11b-hexahydro-10-methoxy-2H-[1]benzoxepino[5,4-b]-1,4-oxa zine, are prepared by acylating a trans-4-amino-2,3,4,5-tetrahydro-1-benzoxepin-5-ol, cyclizing the resulting chloroacetamido alcohol, reducing the 1,4-oxazine-3(4H)-one so obtained, acylating the resulting 2H-[1]-benzoxepino[5,4-b]-1,4-oxazine, and reducing the N-acryl-2H-[1]benzoxepino[5,4-b]-1,4-oxazine so obtained. The novel compounds disclosed herein possess useful antihypertensive properties.
    Type: Grant
    Filed: October 29, 1987
    Date of Patent: August 23, 1988
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Jules Freedman, Richard C. Dage
  • Cardiotonic alkanoylthiazolones
    Patent number: 4762849
    Abstract: Novel alkanoylthiazolones enhance myocardial contractile force and are useful as cardiotonics in the treatment of heart failure.
    Type: Grant
    Filed: October 15, 1985
    Date of Patent: August 9, 1988
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: J. Martin Grisar, Richard C. Dage, Richard A. Schnettler
  • Cardiotonic tricyclic imidazolones
    Patent number: 4743607
    Abstract: Tricyclic imidazolones enhance myocardial contractile force and are useful as cardiotonics in the treatment of heart failure.
    Type: Grant
    Filed: May 29, 1987
    Date of Patent: May 10, 1988
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Winton D. Jones, George P. Claxton, Richard A. Schnettler, Richard C. Dage
  • Cardiotonic aroylthiazolones and the use thereof
    Patent number: 4734422
    Abstract: Aroylthiazolones enhance myocardial contractile force and are useful as cardiotonics in the treatment of heart failure.
    Type: Grant
    Filed: February 26, 1987
    Date of Patent: March 29, 1988
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: J. Martin Grisar, Richard C. Dage, Richard A. Schnettler
  • Novel alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones
    Patent number: 4732982
    Abstract: This invention relates to alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones and to their use as cardiotonic agents useful in treating cardiac failure, and to the process useful in the preparation thereof.
    Type: Grant
    Filed: February 28, 1986
    Date of Patent: March 22, 1988
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Winton D. Jones, Richard A. Schnettler, Richard C. Dage
  • Certain 5-acyl-1,2-dihydro-2-oxo-3-pyridinecarbonitriles which are useful as cardiotonic agents
    Patent number: 4731371
    Abstract: Novel 5-acyl-2-(1H)pyridinones and their use as cardiotonic agents. Typical of the compounds is 5-acetyl-1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile which is prepared by condensing anionic cyano acetamide with 3-[(dimethylamino)methylenyl]-2,4-pentanedione in an inert organic solvent.
    Type: Grant
    Filed: May 27, 1986
    Date of Patent: March 15, 1988
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Winton D. Jones, Richard A. Schnettler, Richard C. Dage
  • Cardiotonic heterocyclocarbonyl- and acetyl-thiazolones
    Patent number: 4623651
    Abstract: Heterocyclocarbonyl- and acetyl-thiazolones enhance myocardial contractile force and are useful as cardiotonics in the treatment of heart failure.
    Type: Grant
    Filed: October 15, 1985
    Date of Patent: November 18, 1986
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: J. Martin Grisar, Richard C. Dage, Richard A. Schnettler
  • 5-Acyl-2-(1H)-pyridinones
    Patent number: 4568751
    Abstract: Novel 5-acyl-2-(1H)pyridinones and their use as cardiotonic agents. Typical of the compounds is 5-acetyl-1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile which is prepared by condensing anionic cyano acetamide with 3-[(dimethylamino)methylenyl]-2,4-pentanedione in an inert organic solvent.
    Type: Grant
    Filed: April 29, 1983
    Date of Patent: February 4, 1986
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Winton D. Jones, Richard C. Dage, Richard A. Schnettler
  • Pyrrole-3-carboxylate cardiotonic agents
    Patent number: 4560700
    Abstract: Pyrrole-3-carboxylates of the following general structure ##STR1## wherein R.sub.1 is a hydrogen or lower alkyl group; R.sub.2 is a 1 to 8 carbon atom alkyl group; and R.sub.3 is a hydrogen, lower alkyl, pyridyl, pyridylmethyl, pyrryl, pyrrylmethyl, thienyl, thienylmethyl or phenyl or benzyl optionally substituted with one or two lower alkyl, lower alkoxy, lower alkylthio, halogen, nitro, hydroxy, carboxy or cyano groups or with a methylenedioxy group.
    Type: Grant
    Filed: February 8, 1985
    Date of Patent: December 24, 1985
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Richard A. Schnettler, Richard C. Dage, J. Martin Grisar