Patents by Inventor Richard C. Flagan

Richard C. Flagan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190120743
    Abstract: The present disclosure describes a compact and lightweight, radial-flow DMA designed to operate at low aerosol and sheath flowrates (on the order of 0.3 L/min aerosol flow, and 0.6-1.2 L/min sheath flow) and so as to classify aerosols including particles having sizes in the 10-500 nm range. Thus, the DMA is capable of operating at relatively low resolution (RND=2-4) to minimize both instrument volume and pumping/power requirements, while enabling size distribution measurement with the precision required for desired applications.
    Type: Application
    Filed: October 16, 2018
    Publication date: April 25, 2019
    Applicant: California Institute of Technology
    Inventors: Richard C. Flagan, Stavros Amanatidis, Changhyuk Kim
  • Patent number: 9177774
    Abstract: A continuous flow mobility classifier provide the ability to perform two-dimensional separation in mass spectrometry. An ionization system is used to ionize a sample. A differential mobility analyzer (DMA) (e.g., a nano-radial DMA) is coupled to the ionization system and to a mass spectrometer. The nano-RDMA is configured to separate the ionized sample by mobility for subsequent mass analysis by the mass spectrometer.
    Type: Grant
    Filed: January 18, 2011
    Date of Patent: November 3, 2015
    Assignee: California Institute of Technology
    Inventors: Nicholas Brunelli, Konstantinos P. Giapis, Richard C. Flagan, Jesse L. Beauchamp, Evan Neidholdt
  • Patent number: 9138663
    Abstract: A method is provided for changing a property of a sample. A sample, comprising particles suspended within a sample fluid, is introduced into a channel which comprises two walls that are permeable to a flow of fluid. A cross-flow is introduced at a predetermined temperature and of a predetermined chemical composition into the channel through a wall. This cross-flow flows at a first velocity and exits in a first direction through the other wall. An imposed field is applied on the particles in a second direction counter to the first direction of the cross-flow. The imposed field causes the particles to migrate at a second velocity opposite and/or equal to the first velocity of the cross-flow. Particles that are approximately balanced by the first and second velocities travel through the channel and are discharged in a fluid of predetermined chemical composition and at the predetermined temperature of the cross-flow.
    Type: Grant
    Filed: February 15, 2013
    Date of Patent: September 22, 2015
    Assignee: California Institute of Technology
    Inventors: Richard C. Flagan, Wilton Mui, Andrew J. Downard
  • Patent number: 9116128
    Abstract: Micro-cavity resonant sensors have outer surfaces that are functionalized using click chemistry, e.g., involving a cycloaddition reaction of an alkyne functional group and an azide functional group. A first polymer linking element binds to an outer surface of the micro-cavity and has an azide functional group, which bonds to an alkyne functional group of a second polymer linking element as a result of a cycloaddition reaction. A functionalization element such as an antibody, antigen or protein for sensing a target molecule is bound to the second linking element.
    Type: Grant
    Filed: January 9, 2012
    Date of Patent: August 25, 2015
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Andrea M. Armani, Akinleye C. Alabi, Mark E. Davis, Richard C. Flagan, Scott E. Fraser
  • Patent number: 9095793
    Abstract: A radial opposed migration classifier is provided for separating particles in a sample, introducing and removing the particles into and out of the classifier at the same potential. A sample passes through a classification channel having two circular walls. The sample is introduced and exits the classifier through the same plane as the first wall, which is at a different potential from the second wall. A cross-flow fluid enters the classification channel through one of the walls. The cross-flow fluid flows at a first velocity and exits in a first direction through the other wall. An imposed field is applied on the particles in a second direction counter to the first direction of the cross-flow. This causes the particles of a desired size and/or charge to migrate at a second velocity opposite and/or equal to a first velocity of the cross-flow. The particles that travel through the channel are discharged.
    Type: Grant
    Filed: February 15, 2013
    Date of Patent: August 4, 2015
    Assignee: California Institute of Technology
    Inventors: Richard C. Flagan, Wilton Mui, Andrew J. Downard
  • Patent number: 8748730
    Abstract: Systems and methods for concentrating solar energy without tracking the sun are provided. In one embodiment, the invention relates to a solar collector assembly for collecting and concentrating light for solar cell assemblies, the collector assembly including an array of solar collectors, each including a funnel shaped collector including a side wall defining a tapered opening having a base aperture and an upper aperture, the side wall including an outer surface, and a solar cell assembly positioned at the base aperture, where the outer surface is coated with a material that substantially reflects light, where the upper aperture is wider than the base aperture, where the funnel shaped collector is configured to substantially confine light, incident via the upper aperture, within the funnel shaped collector until the light exits proximate the base aperture, and where the solar cell assembly is configured to capture light exiting the base aperture.
    Type: Grant
    Filed: March 13, 2010
    Date of Patent: June 10, 2014
    Assignee: California Institute of Technology
    Inventors: Julia A. Kornfield, Richard C. Flagan
  • Patent number: 8597577
    Abstract: An optoelectronic swept-frequency semiconductor laser coupled to a microfabricated optical biomolecular sensor with integrated resonator and waveguide and methods related thereto are described. Biomolecular sensors with optical resonator microfabricated with integrated waveguide operation can be in a microfluidic flow cell.
    Type: Grant
    Filed: February 18, 2011
    Date of Patent: December 3, 2013
    Assignee: California Institute of Technology
    Inventors: Richard C. Flagan, Amnon Yariv, Jason Gamba, Naresh Satyan, Jacob Sendowski, Arseny Vasilyev
  • Patent number: 8310677
    Abstract: Micro-cavity gas or vapor sensors and gas or vapor detection methods. Optical energy is introduced into a resonant micro-cavity having a deformable coating such as a polymer. The coating swells or expands when it is exposed to or absorbs a gas or vapor, thereby changing the resonant wavelength of optical energy circulating within the micro-cavity/coating. Expansion or swelling of the coating may be reversible such that it contracts when gas or vapor diffuses from the coating. The coating deformation and/or a change of one or more optical properties of the optical energy circulating within the micro-cavity are used to detect the presence of the gas or vapor or molecules or particulates thereof.
    Type: Grant
    Filed: January 30, 2012
    Date of Patent: November 13, 2012
    Assignee: California Institute of Technology
    Inventors: Andrea M. Armani, Tsu-Te J. Su, Richard C. Flagan, Scott E. Fraser
  • Publication number: 20120156802
    Abstract: An optoelectronic swept-frequency semiconductor laser coupled to a microfabricated optical biomolecular sensor with integrated resonator and waveguide and methods related thereto are described. Biomolecular sensors with optical resonator microfabricated with integrated waveguide operation can be in a microfluidic flow cell.
    Type: Application
    Filed: February 18, 2011
    Publication date: June 21, 2012
    Inventors: Richard C. FLAGAN, Amnon YARIV, Jason GAMBA, Naresh SATYAN, Jacob SENDOWSKI, Arseny VASILYEV
  • Publication number: 20120120398
    Abstract: Micro-cavity gas or vapor sensors and gas or vapor detection methods. Optical energy is introduced into a resonant micro-cavity having a deformable coating such as a polymer. The coating swells or expands when it is exposed to or absorbs a gas or vapor, thereby changing the resonant wavelength of optical energy circulating within the micro-cavity/coating. Expansion or swelling of the coating may be reversible such that it contracts when gas or vapor diffuses from the coating.
    Type: Application
    Filed: January 30, 2012
    Publication date: May 17, 2012
    Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Andrea M. Armani, Tsu-Te J. Su, Richard C. Flagan, Scott E. Fraser
  • Publication number: 20120107177
    Abstract: Micro-cavity resonant sensors have outer surfaces that are functionalized using click chemistry, e.g., involving a cycloaddition reaction of an alkyne functional group and an azide functional group. A first polymer linking element binds to an outer surface of the micro-cavity and has an azide functional group, which bonds to an alkyne functional group of a second polymer linking element as a result of a cycloaddition reaction. A functionalization element such as an antibody, antigen or protein for sensing a target molecule is bound to the second linking element.
    Type: Application
    Filed: January 9, 2012
    Publication date: May 3, 2012
    Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Andrea M. Armani, Akinleye C. Alabi, Mark E. Davis, Richard C. Flagan, Scott E. Fraser
  • Patent number: 8107081
    Abstract: Micro-cavity gas or vapor sensors and gas or vapor detection methods. Optical energy is introduced into a resonant micro-cavity having a deformable coating such as a polymer. The coating swells or expands when it is exposed to or absorbs a gas or vapor, thereby changing the resonant wavelength of optical energy circulating within the micro-cavity/coating. Expansion or swelling of the coating may be reversible such that it contracts when gas or vapor diffuses from the coating. The coating deformation and/or a change of one or more optical properties of the optical energy circulating within the micro-cavity are used to detect the presence of the gas or vapor or molecules or particulates thereof.
    Type: Grant
    Filed: October 1, 2008
    Date of Patent: January 31, 2012
    Assignee: California Institute of Technology
    Inventors: Andrea M. Armani, Tsu-Te J. Su, Richard C. Flagan, Scott E. Fraser
  • Patent number: 8092855
    Abstract: Micro-cavity resonant sensors have outer surfaces that are functionalized using click chemistry, e.g., involving a cycloaddition reaction of an alkyne functional group and an azide functional group. A first polymer linking element binds to an outer surface of the micro-cavity and has an azide functional group, which bonds to an alkyne functional group of a second polymer linking element as a result of a cycloaddition reaction. A functionalization element such as an antibody, antigen or protein for sensing a target molecule is bound to the second linking element.
    Type: Grant
    Filed: November 26, 2008
    Date of Patent: January 10, 2012
    Assignee: California Institute of Technology
    Inventors: Andrea M. Armani, Akinleye C. Alabi, Mark E. Davis, Richard C. Flagan, Scott E. Fraser
  • Publication number: 20110174964
    Abstract: A continuous flow mobility classifier provide the ability to perform two-dimensional separation in mass spectrometry. An ionization system is used to ionize a sample. A differential mobility analyzer (DMA) (e.g., a nano-radial DMA) is coupled to the ionization system and to a mass spectrometer. The nano-RDMA is configured to separate the ionized sample by mobility for subsequent mass analysis by the mass spectrometer.
    Type: Application
    Filed: January 18, 2011
    Publication date: July 21, 2011
    Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Nicholas Brunelli, Konstantinos P. Giapis, Richard C. Flagan, Jesse L. Beauchamp, Evan Neidholdt
  • Publication number: 20100258170
    Abstract: Systems and methods for concentrating solar energy without tracking the sun are provided. In one embodiment, the invention relates to a solar collector assembly for collecting and concentrating light for solar cell assemblies, the collector assembly including an array of solar collectors, each including a funnel shaped collector including a side wall defining a tapered opening having a base aperture and an upper aperture, the side wall including an outer surface, and a solar cell assembly positioned at the base aperture, where the outer surface is coated with a material that substantially reflects light, where the upper aperture is wider than the base aperture, where the funnel shaped collector is configured to substantially confine light, incident via the upper aperture, within the funnel shaped collector until the light exits proximate the base aperture, and where the solar cell assembly is configured to capture light exiting the base aperture.
    Type: Application
    Filed: March 13, 2010
    Publication date: October 14, 2010
    Inventors: Julia A. Kornfield, Richard C. Flagan
  • Publication number: 20090214755
    Abstract: Micro-cavity resonant sensors have outer surfaces that are functionalized using click chemistry, e.g., involving a cycloaddition reaction of an alkyne functional group and an azide functional group. A first polymer linking element binds to an outer surface of the micro-cavity and has an azide functional group, which bonds to an alkyne functional group of a second polymer linking element as a result of a cycloaddition reaction. A functionalization element such as an antibody, antigen or protein for sensing a target molecule is bound to the second linking element.
    Type: Application
    Filed: November 26, 2008
    Publication date: August 27, 2009
    Inventors: Andrea M. Armani, Akinleye C. Alabi, Mark E. Davis, Richard C. Flagan, Scott E. Fraser
  • Publication number: 20090097031
    Abstract: Micro-cavity gas or vapor sensors and gas or vapor detection methods. Optical energy is introduced into a resonant micro-cavity having a deformable coating such as a polymer. The coating swells or expands when it is exposed to or absorbs a gas or vapor, thereby changing the resonant wavelength of optical energy circulating within the micro-cavity/coating. Expansion or swelling of the coating may be reversible such that it contracts when gas or vapor diffuses from the coating. The coating deformation and/or a change of one or more optical properties of the optical energy circulating within the micro-cavity are used to detect the presence of the gas or vapor or molecules or particulates thereof.
    Type: Application
    Filed: October 1, 2008
    Publication date: April 16, 2009
    Inventors: Andrea M. Armani, Tsu-te J. Su, Richard C. Flagan, Scott E. Fraser
  • Patent number: 7407531
    Abstract: A system is disclosed for condensation particle counting in conjunction with modifying an aerosol to enhance the formation and growth of droplets of a selected working fluid, preferably water. Before saturation with the working fluid, the aerosol is exposed to an aerosol modifying component, preferably a vapor including molecules that are adsorbed onto surfaces of the particles or other elements suspended in the aerosol. Adsorption alters the surface character of the suspended elements towards increased affinity for the vapor of the working fluid, to promote the formation and growth of working fluid droplets. The droplets are optically detected to indicate numbers and concentrations of the suspended elements.
    Type: Grant
    Filed: May 9, 2005
    Date of Patent: August 5, 2008
    Assignees: TSI Incorporated, California Institute of Technology
    Inventors: Richard C. Flagan, Stanley L. Kaufman, Gilmore J. Sem
  • Patent number: 7297619
    Abstract: A system and method for making nanoparticles. The system includes a first cathode including a first metal tube associated with a first end and a second end, a first anode including a second metal tube associated with a third end and a fourth end, and a first container including a first gas inlet. The first end and the third end are located inside the first container. The first end and the third end are separated by a first gap, the first metal tube is configured to allow a first gas to flow from the second end to the first end, and the first container is configured to allow a second gas to flow from the first gas inlet into the second metal tube through at least a first part of the first gap.
    Type: Grant
    Filed: May 4, 2005
    Date of Patent: November 20, 2007
    Assignee: California Institute of Technology
    Inventors: R. Mohan Sankaran, Konstantinos P. Giapis, Richard C. Flagan, Dean Holunga
  • Patent number: 6905029
    Abstract: A method, system, apparatus, and article of manufacture provide a cross-flow migration classifier capable of separating particles. The classifier provides a channel through which a sample, having one or more particles, passes in a first direction, wherein the channel comprises two or more walls that are permeable to a flow of fluid. A cross-flow enters the channel through one of the permeable walls and exits through another of the permeable walls. An imposed field is applied in a second direction that is counter to the cross-flow and having an orthogonal component to the first direction. The imposed field causes one or more of the particles to migrate at a first velocity opposite and/or equal to a second velocity of the cross-flow. The particles that migrate opposite to the cross-flow are continuously discharged from the cross-flow migration classifier.
    Type: Grant
    Filed: August 29, 2003
    Date of Patent: June 14, 2005
    Assignee: California Institute of Technology
    Inventor: Richard C. Flagan