Abstract: The present disclosure provides for cancer treatment methods related to the unexpected discovery of the role of mannan-binding protein-associated serine protease-2 (MASP-2) in cancer. Improved cancer treatment methods are disclosed that are determined by measuring changes in levels of MASP-2, a previously unknown biomarker for cancer. It has been discovered that changes in MASP-2 levels are useful as indications of cancer progression, chemotherapeutic responsiveness, and cancer remission, such as in pancreatic cancers. More particularly, changes of levels in MASP-2 in extracellular vesicles (EVs), i.e. EV-MASP2, from patient blood samples are useful for providing effective and targeted cancer treatment regimens, such as in pancreatic cancers. The present disclosure further includes compositions and methods related to inhibiting MASP-2 for the treatment of cancers.

Abstract: The present disclosure provides for cancer treatment methods related to the unexpected discovery of the role of mannan-binding protein-associated serine protease-2 (MASP-2) in cancer. Improved cancer treatment methods are disclosed that are determined by measuring changes in levels of MASP-2, a previously unknown biomarker for cancer. It has been discovered that changes in MASP-2 levels are useful as indications of cancer progression, chemotherapeutic responsiveness, and cancer remission, such as in pancreatic cancers. More particularly, changes of levels in MASP-2 in extracellular vesicles (EVs), i.e. EV-MASP2, from patient blood samples are useful for providing effective and targeted cancer treatment regimens, such as in pancreatic cancers. The present disclosure further includes compositions and methods related to inhibiting MASP-2 for the treatment of cancers.

Abstract: In an example, a graphical user interface can be used to display a graphical representation of a virtual reference structure for an anatomic structure, the reference structure being determined from geometry of the anatomic structure. A location parameter along the reference structure is determined in response to a first user input from a user input device. A graphical proxy marker is displayed on the graphical representation of the reference structure based on the location parameter. A fixed location is selected along the reference structure for a final graphical marker in response to a second user input from the from the user input device. An output visualization is generated to include at least one view of the anatomic structure and a graphical representation of the final graphical marker at the fixed location.

Abstract: In an example, a graphical user interface can be used to display a graphical representation of a virtual reference structure for an anatomic structure, the reference structure being determined from geometry of the anatomic structure. A location parameter along the reference structure is determined in response to a first user input from a user input device. A graphical proxy marker is displayed on the graphical representation of the reference structure based on the location parameter. A fixed location is selected along the reference structure for a final graphical marker in response to a second user input from the from the user input device. An output visualization is generated to include at least one view of the anatomic structure and a graphical representation of the final graphical marker at the fixed location.

Abstract: In an example, a graphical user interface can be used to display a graphical representation of a virtual reference structure for an anatomic structure, the reference structure being determined from geometry of the anatomic structure. A location parameter along the reference structure is determined in response to a first user input from a user input device. A graphical proxy marker is displayed on the graphical representation of the reference structure based on the location parameter. A fixed location is selected along the reference structure for a final graphical marker in response to a second user input from the from the user input device. An output visualization is generated to include at least one view of the anatomic structure and a graphical representation of the final graphical marker at the fixed location.

Abstract: In an example, a method includes selecting a user-selected seed voxel from a medical image. The user-selected seed voxel is shifted to an adjusted seed voxel in an evaluation region based on an evaluation. The evaluation region includes the user-selected seed voxel and at least one other voxel within a predetermined spatial distance. A given region in the image volume is filled with voxels to provide a segmented volume for the given region based on the adjusted seed voxel and segmentation filter parameters. A segmentation region is evaluated to ascertain a quality of the fill. Seed candidates may be determined from a set of the filled voxels adjacent a boundary of the for another region given region in response to determining that the quality of the fill indicates a valid segmentation for the anatomic vessel structure in the given region. Segmented vessel image data is stored.

Abstract: In an example, a graphical user interface can be used to display a graphical representation of a virtual reference structure for an anatomic structure, the reference structure being determined from geometry of the anatomic structure. A location parameter along the reference structure is determined in response to a first user input from a user input device. A graphical proxy marker is displayed on the graphical representation of the reference structure based on the location parameter. A fixed location is selected along the reference structure for a final graphical marker in response to a second user input from the from the user input device. An output visualization is generated to include at least one view of the anatomic structure and a graphical representation of the final graphical marker at the fixed location.

Abstract: In an example, a method includes selecting a user-selected seed voxel from a medical image. The user-selected seed voxel is shifted to an adjusted seed voxel in an evaluation region based on an evaluation. The evaluation region includes the user-selected seed voxel and at least one other voxel within a predetermined spatial distance. A given region in the image volume is filled with voxels to provide a segmented volume for the given region based on the adjusted seed voxel and segmentation filter parameters. A segmentation region is evaluated to ascertain a quality of the fill. Seed candidates may be determined from a set of the filled voxels adjacent a boundary of the for another region given region in response to determining that the quality of the fill indicates a valid segmentation for the anatomic vessel structure in the given region. Segmented vessel image data is stored.