Patents by Inventor Richard C. Gehrz

Richard C. Gehrz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Immunogenic glycoproteins of human cytomegalovirus
    Patent number: 5248768
    Abstract: Glycopeptides of human cytomegalovirus have been isolated and purified. These glycopeptides and antibodies reactive with them are useful in diagnosis and therapy.
    Type: Grant
    Filed: June 26, 1991
    Date of Patent: September 28, 1993
    Assignee: The Children's Hospital, Incorporated
    Inventors: Nancy O. Lussenhop, Bruce E. Kari, Richard C. Gehrz
  • Immunogenic glycoproteins of human cytomegalovirus gCII
    Patent number: 5153311
    Abstract: Substantially-pure immunogenic glycoprotein complexes of the gCII family, and constituent glycoproteins which can be derived from the membrane envelope of human cytomegalovirus are provided.
    Type: Grant
    Filed: August 3, 1988
    Date of Patent: October 6, 1992
    Assignee: The Children's Hospital, Incorporated
    Inventors: Bruce E. Kari, Richard C. Gehrz
  • Monoclonal antibodies reactive with specific antigenic sites on human cytomegalovirus glycoprotein A
    Patent number: 5126130
    Abstract: The present invention is directed to a composition containing a first monoclonal antibody, capable of neutralizing human cytomegalovirus (HCMV), that binds to a first epitope on HCMV GCA, and a second non-neutralizing HCMV monoclonal antibody that binds to a second epitope on HCMV GCA. The GCA complex includes antigenically-related glycoproteins of molecular weights 130,000, 93,000, and 50,000-52,000 kDa. The mixture of the two antibodies has greater neutralizing activity than a composition containing the first antibody alone. Also provided is a method for neutralizing the infectivity of HCMV using the composition.
    Type: Grant
    Filed: August 7, 1987
    Date of Patent: June 30, 1992
    Assignee: The Childrens Hospital Incorporated
    Inventors: Nancy O. Lussenhop, Bruce E. Kari, Richard C. Gehrz
  • Antibody and T cell recognition sites on glycoproteins comprising the GCI complex of human cytomegalovirus
    Patent number: 5124440
    Abstract: Glycopeptides of the gcI (gB) complex of human cytomegalovirus are disclosed. They possess unique B cell and T cell epitopes not present in other gcI glycopeptides. Glycopeptide fragments which comprise minimal antigenic determinants of the gcI complex are also disclosed, as are recombinant expression vectors, vaccines, and diagnostic methods.
    Type: Grant
    Filed: March 24, 1989
    Date of Patent: June 23, 1992
    Assignees: The Childrens Hospital, Inc., University of Iowa Research Foundation
    Inventors: Richard C. Gehrz, Mark F. Stinski, Bruce I. Kari, Yung-Nan Liu