Patents by Inventor Richard C. Hoying

Richard C. Hoying has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chiral intermediates for the preparation of carbacephems
    Patent number: 5700933
    Abstract: The present invention is directed to azetidinone compounds of the following formula: ##STR1## which are useful as intermediates to carbacephalosporins: ##STR2## These carbacephalosporins are useful as antibacterials.
    Type: Grant
    Filed: May 18, 1995
    Date of Patent: December 23, 1997
    Assignee: Eli Lilly and Company
    Inventors: Jack W. Fisher, Lowell D. Hatfield, Richard C. Hoying, James E. Ray
  • Intermediates for the preparation of carbacephems
    Patent number: 5644051
    Abstract: This invention is directed to carbacephems and methods for their preparation: ##STR1## In the foregoing formulae, R.sup.3 represents phenyl, C.sub.1 -C.sub.4 alkylphenyl, halophenyl, C.sub.1 -C.sub.4 alkoxyphenyl, naphthyl, thienyl, furyl, benzothienyl, or benzofuryl.
    Type: Grant
    Filed: May 18, 1995
    Date of Patent: July 1, 1997
    Assignee: Eli Lilly and Company
    Inventors: Jack W. Fisher, Lowell D. Hatfield, Richard C. Hoying, James E. Ray
  • Methods and compounds for the preparation of carbacephems
    Patent number: 5521307
    Abstract: A chiral process for preparing compounds of the formula: ##STR1## from a compound of the formula: ##STR2## in which the compound formula (IV) is reacted with trimethylsilyl iodide to remove the chiral auxiliary at the 7-position and the carboxy protecting group. The process allows for the retention of the amino and carboxy protecting groups throughout the preparation of Compound IV. Also disclosed are novel intermediates.
    Type: Grant
    Filed: February 18, 1992
    Date of Patent: May 28, 1996
    Assignee: Eli Lilly and Company
    Inventors: Jack W. Fisher, Lowell D. Hatfield, Richard C. Hoying, James E. Ray
  • DMF solvates of a .beta.-lactam antibiotic
    Patent number: 4977257
    Abstract: The crystalline bis(DMF), dihydrate mono(DMF) and mono(DMF) forms of 7.beta.-[2'-(R)-2'-phenyl-2'-aminoacetamido[-3-chloro-3-(1-carbadethiaceph em)-4-carboxylic acid (LY163892) are useful intermediates to the monohydrate form of LY163892.
    Type: Grant
    Filed: May 29, 1990
    Date of Patent: December 11, 1990
    Assignee: Eli Lilly and Company
    Inventors: Thomas M. Eckrich, Richard C. Hoying
  • Preparation of substituted 2-aminopyrazines
    Patent number: 4211870
    Abstract: Preparation of substituted 2-aminopyrazines by reaction of an .alpha.-chloro or .alpha.-bromo oxime with an aminoacetonitrile in the presence of an acid-uptake agent, followed by separation of the intermediate novel hydroxyimino-substituted aminoacetonitrile, and cyclization thereof with acid.
    Type: Grant
    Filed: April 6, 1979
    Date of Patent: July 8, 1980
    Assignee: Eli Lilly and Company
    Inventors: Charles J. Barnett, Thomas L. Emmick, Richard C. Hoying