Abstract: A system for facilitating the purchase and sale of advertising including a server with a non-transient computer readable storage medium. The server is in communication with at least one user device through a network, the user device being configured to receive user input. The server receives from the user device at least one Promotional Avail (PA) which includes a plurality of customizable elements of user input. The display of the user device presents a user interface, which is configured to present information related to the customizable elements in real time. The server is configured to cause to be presented proof-of-performance information to be presented on the user interface in response to a request.

Abstract: The present invention relates to compositions and methods for altering (e.g., enhancing) RNAi. In particular, the present invention provides systems and methods for identifying regulators of RNAi. For example, the present invention provides RNAi regulators (e.g., HPS1 and HPS4) and methods of altering (e.g., inhibiting) these regulators in order to alter (e.g., enhance) RNAi. The present invention also provides methods of identifying inhibitors (e.g., small molecule, nucleic acid (e.g., siRNA), and antibody) of RNAi regulators and methods of using the same (e.g., to enhance RNAi). Compositions and methods of the present invention find use in research (e.g., functional genomics), therapeutic (e.g., drug discovery and delivery) and clinical applications.