Patents by Inventor Richard Carvajal

Richard Carvajal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190376149
    Abstract: The present invention relates to methods and compositions for determining the likelihood that a subject suffering from a cancer will benefit from treatment with a MEK inhibitor. It also relates to methods of treatment based on such determination. The invention is based, at least in part, on the discoveries that DDX43 mRNA and protein are expressed at high levels in biopsies from “non-responder” UM patients and that selumetinib-resistant cell lines showed high DDX43 expression which correlated with increased expression and activity of RAS. It was found that KRAS and HRAS but not NRAS, mediated expression of pERK and pAKT, bypassing oncogenic GNAQ. The invention is further based on the discovery that selumetinib-resistant cells became sensitive to AKT inhibition, suggesting alternative strategies for the treatment of cancer patients with acquired resistance to MEK inhibitors.
    Type: Application
    Filed: July 23, 2019
    Publication date: December 12, 2019
    Applicant: MEMORIAL SLOAN-KETTERING CANCER CENTER
    Inventors: Grazia Ambrosini, Raya Khanin, Richard Carvajal, Gary K. Schwartz
  • Patent number: 10400285
    Abstract: The present invention relates to methods and compositions for determining the likelihood that a subject suffering from a cancer will benefit from treatment with a MEK inhibitor. It also relates to methods of treatment based on such determination. The invention is based, at least in part, on the discoveries that DDX43 mRNA and protein are expressed at high levels in biopsies from “non-responder” UM patients and that selumetinib-resistant cell lines showed high DDX43 expression which correlated with increased expression and activity of RAS. It was found that KRAS and HRAS but not NRAS, mediated expression of pERK and pAKT, bypassing oncogenic GNAQ. The invention is further based on the discovery that selumetinib-resistant cells became sensitive to AKT inhibition, suggesting alternative strategies for the treatment of cancer patients with acquired resistance to MEK inhibitors.
    Type: Grant
    Filed: March 4, 2016
    Date of Patent: September 3, 2019
    Assignee: Memorial Sloan-Kettering Cancer Center
    Inventors: Grazia Ambrosini, Raya Khanin, Richard Carvajal, Gary K. Schwartz
  • Publication number: 20160258027
    Abstract: The present invention relates to methods and compositions for determining the likelihood that a subject suffering from a cancer will benefit from treatment with a MEK inhibitor. It also relates to methods of treatment based on such determination. The invention is based, at least in part, on the discoveries that DDX43 mRNA and protein are expressed at high levels in biopsies from “non-responder” UM patients and that selumetinib-resistant cell lines showed high DDX43 expression which correlated with increased expression and activity of RAS. It was found that KRAS and HRAS but not NRAS, mediated expression of pERK and pAKT, bypassing oncogenic GNAQ. The invention is further based on the discovery that selumetinib-resistant cells became sensitive to AKT inhibition, suggesting alternative strategies for the treatment of cancer patients with acquired resistance to MEK inhibitors.
    Type: Application
    Filed: March 4, 2016
    Publication date: September 8, 2016
    Applicant: Memorial Sloan-Kettering Cancer Center
    Inventors: Grazia Ambrosini, Raya Khanin, Richard Carvajal, Gary K. Schwartz
  • Publication number: 20070080518
    Abstract: The invention relates to an autonomous electromagnetic control system for binding boots to a electromagnetic control system for binding boots to a snowboard, skis or generally any board used for sports, surf as a skateboard or a surfboard. The inventive system is disposed on the clothing and boots of the sportsperson as well as on the board, in order to ensure the safe practice of said sports. According to the invention, the system comprises: rechargeable batteries; electric or solar chargers; power switches; electromagnetic gripper elements or electromagnets which are provided in each boot; slabs; sheets or particles of a ferromagnetic material, which are housed in the board(s) on which the boots are positioned and fixed; and optionally, a system fro the transmission/reception of commands, using electromagnetic waves or infrared rays, which is used to control the aforementioned switches and which can be equipped with a voice recognition device.
    Type: Application
    Filed: October 4, 2004
    Publication date: April 12, 2007
    Inventor: Richard Carvajal