Abstract: The invention relates to a computer program comprising a sequence of instructions for execution on a processing unit having instruction storage for holding the computer program, an execution unit for executing the computer program and data storage for holding data, the computer program comprising one or more computer executable instruction which, when executed, implements: a send function which causes a data packet destined for a recipient processing unit to be transmitted on a set of connection wires connected to the processing unit, the data packet having no destination identifier but being transmitted at a predetermined transmit time; and a switch control function which causes the processing unit to control switching circuitry to connect a set of connection wires of the processing unit to a switching fabric to receive a data packet at a predetermined receive time.

Abstract: Ozone generator (1) for generating ozone comprising at least one high voltage electrode HVE (2), two low voltage electrodes LVE (3), at least one dielectric (4) and an electric isolator (25) placed in an area between the two LVE (3?, 3?). The generator (1) further comprises a first gap (7) and a second gap (8) and at least one of the gaps (7, 8) is a corona chamber. The at least one dielectric (4) comprising a first surface (9) is turning towards a HVE-surface (22) and an opposite second surface (10) is turning towards a first surface (17) of one of the LVE (3). The second surface (10) of the dielectric (4) is directly or indirectly supported in its full extension by the first LVE-surface (17), and at least one of the gaps (7, 8) is placed between the first surface (9) of the dielectric (4) and a first HVE-surface (22), said gap is a corona-chamber adapted to develop ozone.

Abstract: The present invention provides, among other things, compositions and methods for CNS delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some embodiments, the present invention includes a stable formulation for direct CNS intrathecal administration comprising an iduronate-2-sulfatase (I2S) protein, salt, and a polysorbate surfactant for the treatment of Hunters Syndrome.

Abstract: Devices for the disruption and/or removal of obstructive material in a blood vessel. The device can comprise an elongated shaft having a proximal portion, a distal portion, and a lumen extending therebetween. The device can further comprise a capture structure carried by the distal portion of the elongated shaft and having a greater cross-sectional dimension than a cross-sectional dimension of the elongated shaft. The capture structure can comprise an opening at a first end portion that is fluidly coupled to the lumen of the elongated shaft, a fluid impermeable sidewall enclosing an interior region, and an opening extending through a thickness of the sidewall. A portion of the sidewall surrounding the opening can be configured to deform towards or away from the interior region such that a cross-sectional dimension of the opening increases to receive the obstructive material therethrough.

Abstract: According to some embodiments, the present technology includes a device for the disruption and/or removal of obstructive material in a blood vessel. The device can comprise an elongated shaft having a proximal portion, a distal portion, and a lumen extending therebetween. The device can further comprise a capture structure carried by the distal portion of the elongated shaft and having a greater cross-sectional dimension than a cross-sectional dimension of the elongated shaft. The capture structure can comprise an opening at a first end portion that is fluidly coupled to the lumen of the elongated shaft, a fluid impermeable sidewall enclosing an interior region, and an opening extending through a thickness of the sidewall. A portion of the sidewall surrounding the opening can be configured to deform towards or away from the interior region such that a cross-sectional dimension of the opening increases to receive the obstructive material therethrough.

Abstract: An apparatus and method for endwise connecting subterranean barrier members is disclosed. The apparatus includes at least two barrier members with each barrier member extending between top and bottom edges. Further, each barrier member has a side first edge having a flange defining a first connector and an opposed second side edge having a channel defining a second connector. The channel is sized and shaped to receive the flange of an adjacent barrier member in slidable interconnection therein. The apparatus further include a first side panel shaped to lie against a first side of the barrier members, a second side panel shaped to lie against a second side of the barrier members and a bridging plate located between the first and second panel members so as to bridge a gap therebetween, wherein the gap has a width corresponding to a width of the first and second barrier members. The associated method is directed toward creating the apparatus.

Abstract: A modified chip spreader is adapted to be used in a chip sealing train including a chip supply dump truck and an asphalt composition supply truck. The modified chip spreader is a self-propelled vehicle that has a receiving hopper on its front end for receiving stone chips from the chip supply dump truck, a spreader assembly on its rear end and a conveyor assembly for conveying the stone chips from the receiving hopper to the spreader assembly. The modified chip spreader also includes a spray assembly that is in fluid communication with an outlet line from the asphalt composition supply truck, which spray assembly is adapted to dispense an asphalt composition onto the surface of a roadway in front of the spreader assembly. The spreader assembly dispenses the stone chips onto the newly applied asphalt composition on the surface of the roadway.

Abstract: A CIR train includes a milling machine, an asphalt cement supply tank, a mechanism for dispensing asphalt cement onto paving material that has been removed from the roadway by the milling machine, an asphalt cement pump for pumping asphalt cement from the asphalt cement supply tank into and through an asphalt cement flow circuit to the asphalt cement dispensing mechanism. A heating assembly is interposed in the asphalt cement flow circuit between the asphalt cement supply tank and the dispensing mechanism. The heating assembly includes a heater and a heat modifying component. The heater includes an asphalt cement coil that is in the asphalt cement flow circuit, and a burner that is adapted to direct hot gases of combustion across the asphalt cement coil. The heat modifying component is adapted to modulate the amount of heat transfer from the hot gases of combustion to the asphalt cement in the coil.

Abstract: A system for dispensing asphalt cement in connection with a working operation on a roadway includes a storage tank for asphalt cement and a working machine having a spray assembly for dispensing the asphalt cement. The system also includes a fluid circuit including a pump that is adapted to pump the asphalt cement from the storage tank to the spray assembly. A controller is operatively connected to the pump and is adapted to control the operation of the pump. A cavitation sensor is provided in the fluid circuit. The cavitation sensor is operatively connected to the controller and is adapted to transmit a cavitation signal to the controller when the cavitation sensor detects conditions in the fluid circuit that are indicative of the existence of cavitation in the pump.

Abstract: An apparatus and method for endwise connecting subterranean barrier members is disclosed. The apparatus includes at least two barrier members with each barrier member extending between top and bottom edges. Further, each barrier member has a side first edge having a flange defining a first connector and an opposed second side edge having a channel defining a second connector. The channel is sized and shaped to receive the flange of an adjacent barrier member in slidable interconnection therein. The apparatus further include a first side panel shaped to lie against a first side of the barrier members, a second side panel shaped to lie against a second side of the barrier members and a bridging plate located between the first and second panel members so as to bridge a gap therebetween, wherein the gap has a width corresponding to a width of the first and second barrier members. The associated method is directed toward creating the apparatus.

Abstract: An apparatus and method for endwise connecting subterranean barrier members is disclosed. The apparatus includes at least two barrier members with each barrier member extending between top and bottom edges. Further, each barrier member has a side first edge having a flange defining a first connector and an opposed second side edge having a channel defining a second connector. The channel is sized and shaped to receive the flange of an adjacent barrier member in slidable interconnection therein. The apparatus further include a first side panel shaped to lie against a first side of the barrier members, a second side panel shaped to lie against a second side of the barrier members and a bridging plate located between the first and second panel members so as to bridge a gap therebetween, wherein the gap has a width corresponding to a width of the first and second barrier members. The associated method is directed toward creating the apparatus.

Abstract: A device for treating a patient suffering from obstructive sleep apnea or snoring can include an expiratory valve connected to a manifold. The expiratory valve can include a body portion including a feedback port configured to be connected to an air flow generator. The expiratory valve can include a plunger at least partially disposed in the body portion. The expiratory valve can include a pressurizing chamber positioned between an end of the plunger and an end of the expiratory valve. The pressurizing chamber can be configured to receive air from the air flow generator through the feedback port.

Abstract: A CIR train includes a milling machine, an asphalt cement supply tank, a mechanism for dispensing asphalt cement onto paving material that has been removed from the roadway by the milling machine, an asphalt cement pump for pumping asphalt cement from the asphalt cement supply tank into and through an asphalt cement flow circuit to the asphalt cement dispensing mechanism. A heating assembly is interposed in the asphalt cement flow circuit between the asphalt cement supply tank and the dispensing mechanism. The heating assembly includes a heater and a heat modifying component. The heater includes an asphalt cement coil that is in the asphalt cement flow circuit, and a burner that is adapted to direct hot gases of combustion across the asphalt cement coil. The heat modifying component is adapted to modulate the amount of heat transfer from the hot gases of combustion to the asphalt cement in the coil.

Abstract: A modified chip spreader is adapted to be used in a chip sealing train including a chip supply dump truck and an asphalt composition supply truck. The modified chip spreader is a self-propelled vehicle that has a receiving hopper on its front end for receiving stone chips from the chip supply dump truck, a spreader assembly on its rear end and a conveyor assembly for conveying the stone chips from the receiving hopper to the spreader assembly. The modified chip spreader also includes a spray assembly that is in fluid communication with an outlet line from the asphalt composition supply truck, which spray assembly is adapted to dispense an asphalt composition onto the surface of a roadway in front of the spreader assembly. The spreader assembly dispenses the stone chips onto the newly applied asphalt composition on the surface of the roadway.

Abstract: A device for treating a patient suffering from obstructive sleep apnea or snoring can include an expiratory valve connected to a manifold. The expiratory valve can include a body portion including a feedback port configured to be connected to an air flow generator. The expiratory valve can include a plunger at least partially disposed in the body portion. The expiratory valve can include a pressurizing chamber positioned between an end of the plunger and an end of the expiratory valve. The pressurizing chamber can be configured to receive air from the air flow generator through the feedback port.

Abstract: A CIR train that is adapted to traverse a roadway of asphalt pavement in order to recycle and repair the asphalt pavement includes a milling machine for removing asphalt paving material from the roadway. The CIR train also includes an asphalt cement supply tank and a mechanism for dispensing asphalt cement onto asphalt paving material that has been removed from the roadway. A heater is in fluid communication with the asphalt cement supply tank and the mechanism for dispensing asphalt cement on the asphalt paving material that has been removed from the roadway. The heater is adapted to heat the asphalt cement from the asphalt cement supply tank prior to said asphalt cement being dispensed on the asphalt paving material that has been removed from the roadway.

Abstract: A chip sealing train for use in carrying out a chip sealing operation on a roadway using foamed asphalt cement includes a chip supply dump truck, an asphalt cement supply truck and a chip spreader. The chip spreader includes a receiving hopper for receiving stone chips from the raised dump bed of the chip supply dump truck and a spreader assembly which is adapted to dispense the stone chips onto the roadway. The chip sealing train includes a water tank and a foam dispersal assembly. The foam dispersal assembly includes a foaming chamber, an asphalt cement supply line that is in fluid communication with the asphalt cement supply truck and the foaming chamber, and an asphalt cement pump for pumping asphalt cement from the asphalt cement supply tank into the foaming chamber. The foam dispersal assembly also includes a water supply line that is in fluid communication with the water tank and the foaming chamber, and a water pump for pumping water from the water tank into the foaming chamber.

Abstract: Processes and compositions for 2-heteroaryl substituted benzofuran derivatives are described. The 2-heteroaryl substituted benzofuran derivatives may be suitable for preparing radiolabeled 2-heteroaryl substituted benzofuran derivatives for imaging amyloid deposits in living patients.

Abstract: A method for operating a working machine including a fluid storage tank on a roadway includes providing a spray assembly that is in fluid communication with the fluid storage tank. The spray assembly further includes a plurality of nozzle assemblies, each of which comprises a direct acting valve having a solenoid switch assembly and a valve assembly. The spray assembly also includes a controller that is operatively connected to each of the direct acting valves for controlling the opening and closing thereof. The controller includes a power source, a spray control, an input module and an output module. The input module is operatively connected to the solenoid switch assembly of each nozzle assembly and to the spray control, and it is adapted to determine if the valve assembly of each nozzle assembly is open or closed. The output module is operatively connected to the spray assembly and to the power source, and it is adapted to energize the solenoid switch assembly of each nozzle assembly in the spray assembly.

Abstract: A CIR-modified milling machine includes a milling drum that is adapted to mill material from a roadway, which milling drum is contained in a milling drum housing. An additive spray assembly is located within the milling drum housing and adapted to dispense an asphalt additive therein. An additive flow system includes an inlet line that is adapted to be operatively connected to an external supply line, a surge tank for asphalt additive that is in fluid communication with the additive spray assembly, and an additive pump for pumping asphalt additive from the surge tank to the additive spray assembly.