Abstract: The present disclosure relates to a support apparatus for use on a leg, ankle, and foot cast. The support apparatus attaches to the bottom of the cast and has a first sole and a second sole. The first sole is removable from the second sole providing the cast with both an aggressive tread on the second sole and a moderate tread on the first sole.

Abstract: The present invention relates generally to a diagnostic device including a prognostic assay for parameters which are indicative of a condition or event associated with the systemic vasculature. More particularly, the present invention provides an assay to detect parameters associated with a vascular disease including cardiovascular, stroke, pulmonary, renovascular, cerebrovascular, thrombotic or generalized arterial or venous condition or event including acute coronary syndrome such as but not limited to acute myocardial infarction, heart failure, atheromoma or a thrombotic condition. The identification of these parameters or more particularly a pattern of parameters enables the diagnosis of a condition or event or the determination of the risk of development of a condition or event associated to the systemic vasculature.