Abstract: Syntheses of compounds of Formula III from compounds of Formula I via compounds of Formula II are described, as well as particular compounds of Formula III, or pharmaceutically acceptable salts thereof, compositions comprising such compounds, and uses thereof. For example, certain of these compounds and compositions of Formula III have uses in the treatment of psychiatric or neurological disorders.

Abstract: The present invention relates to compounds of formula I, or pharmaceutically acceptable salts thereof, as well as compositions comprising such compounds. These compounds and compositions have uses in the treatment of psychiatric or neurological disorders. Compounds of formula I comprise at least one deuterium atom at the ?-position and consequently have improved oral bioavailability relative to ?-diprotic analogues.

Abstract: Syntheses of compounds of Formula III from compounds of Formula I via compounds of Formula II are described, as well as particular compounds of Formula III, or pharmaceutically acceptable salts thereof, compositions comprising such compounds, and uses thereof. For example, certain of these compounds and compositions of Formula III have uses in the treatment of psychiatric or neurological disorders.

Abstract: A process and intermediates for making the compound of Formula (I).

Abstract: The present invention relates to compounds of formula I, or pharmaceutically acceptable salts thereof, as well as compositions comprising such compounds. These compounds and compositions have uses in the treatment of psychiatric or neurological disorders. Compounds of formula I comprise at least one deuterium atom at the ?-position and consequently have improved oral bioavailability relative to ?-diprotic analogues.

Abstract: The present invention relates to compounds of formula I, or pharmaceutically acceptable salts thereof, as well as compositions comprising such compounds. These compounds and compositions have uses in the treatment of psychiatric or neurological disorders. Compounds of formula I comprise at least one deuterium atom at the ?-position and consequently have improved oral bioavailability relative to ?-diprotic analogues.

Abstract: Syntheses of compounds of Formula III from compounds of Formula I via compounds of Formula II are described, as well as particular compounds of Formula III, or pharmaceutically acceptable salts thereof, compositions comprising such compounds, and uses thereof. For example, certain of these compounds and compositions of Formula III have uses in the treatment of psychiatric or neurological disorders.

Abstract: A door packing assembly can include a pallet having a plurality of frames positioned thereon. The plurality of frames define an interior area, and a plurality of doors are positioned onto the pallet within the interior area defined by the plurality of frames. In further instances, a door container component can be positioned onto the pallet and the plurality of doors can be positioned within the door container component. In this way, the door container component can have a perimeter surrounded by at least some of the plurality of frames.

Abstract: Embodiments of devices, assemblies, and related methods for transporting glass panels, such as doors, are disclosed. One embodiment of a rack assembly includes a support rack and a first support wedge positioned at the support rack. The first support wedge includes a first end and a second end opposite the first end. The first support wedge further includes a first surface extending between the first end and the second end as well as a second surface extending between the first end and the second end opposite the first surface. The second surface defines a plurality of support platform pairs. Each support platform pair includes a first platform at a first elevation relative to the first surface and a second platform at a second elevation relative to the first surface. The second elevation is different than the first elevation.

Abstract: Embodiments of devices, assemblies, and related methods for transporting glass panels, such as doors, are disclosed. One embodiment of a rack assembly includes a support rack and a first support wedge positioned at the support rack. The first support wedge includes a first end and a second end opposite the first end. The first support wedge further includes a first surface extending between the first end and the second end as well as a second surface extending between the first end and the second end opposite the first surface. The second surface defines a plurality of support platform pairs. Each support platform pair includes a first platform at a first elevation relative to the first surface and a second platform at a second elevation relative to the first surface. The second elevation is different than the first elevation.

Abstract: The present invention pertains generally to the field of organic chemical synthesis, and in particular to certain methods for the synthesis of 8-(4-aminophenyoxy)-4H-pyrido[2,3-b]pyrazin-3-one and related compounds (denoted herein as (3)) from 4-(4-aminophenyoxy)pyridine-2,3-diamine and related compounds (denoted herein as (1)), by reaction with glyoxylic acid (denoted herein as (2)). The compounds (3) are useful in the synthesis of known anti-cancer agents, such as 1-(5-tert-butyl-2-(4-methyl-phenyl)-pyrazol-3-yl)-3-[2-fluoro-4-[(3-oxo-4H-pyrido[2,3-b]pyrazin-8-yl)oxy]phenyl]urea.

Abstract: Door, frame, and door and frame assembly embodiments are disclosed herein. The disclosed embodiments can provide one or more useful insulating features in a variety of applications. One embodiment of a door includes a glass unit and a rail assembly receiving the glass unit. The rail assembly can include a first body having a first sidewall and a first insulating member secured to the first sidewall. The first insulating member can have a first wall and a second wall spaced from the first wall by a first support and a second support. The first wall, the second wall, the first support, and the second support can define a first cavity of the first insulating member.

Abstract: The present invention pertains generally to the field of organic chemical synthesis, and in particular to certain methods for the synthesis of 8-(4-aminophenyoxy)-4H-pyrido[2,3-b[pyrazin-3-one and related compounds (denoted herein as (3)) from 4-(4-aminophenyoxy)pyridine-2,3-diamine and related compounds (denoted herein as (1)), by reaction with glyoxylic acid (denoted herein as (2)). The compounds (3) are useful in the synthesis of known anti-cancer agents, such as 1-(5-tert-butyl-2-(4-methyl-phenyl)-pyrazol-3-yl)-3-[2-fluoro-4-[(3-oxo-4H-pyrido[2,3-b]pyrazin-8-yl)oxy]phenyflurea.

Abstract: The present invention pertains generally to the field of organic chemical synthesis, and in particular to certain methods for the synthesis of 8-(4-aminophenyoxy)-4H-pyrido[2,3-b]pyrazin-3-one and related compounds (denoted herein as (3)) from 4-(4-aminophenyoxy)pyridine-2,3-diamine and related compounds (denoted herein as (1)), by reaction with glyoxylic acid (denoted herein as (2)). The compounds (3) are useful in the synthesis of known anti-cancer agents, such as 1-(5-tert-butyl-2-(4-methyl-phenyl)-pyrazol-3-yl)-3-[2-fluoro-4-[(3-oxo-4H-pyrido[2,3-b]pyrazin-8-yl)oxy]phenyl]urea.

Abstract: A door packing assembly can include a pallet having a plurality of frames positioned thereon. The plurality of frames define an interior area, and a plurality of doors are positioned onto the pallet within the interior area defined by the plurality of frames. In further instances, a door container component can be positioned onto the pallet and the plurality of doors can be positioned within the door container component. In this way, the door container component can have a perimeter surrounded by at least some of the plurality of frames.

Abstract: A door is constructed for a refrigerated cabinet and includes an insulated glass IG unit of rectangular shape and a frame surrounding the unit. The frame is formed of a pair of horizontally disposed aluminum rails and a pair of vertically disposed plastic stiles. Each stile is secured at each end to a respective end of each of the rails by screws. Each rail and stile receives the insulated glass unit in a recessed manner. Full perimeter gasketing of the door is obtained by a vertical gasket on the stile on the hinged side of the door and a pair of horizontal seals on the cabinet opposite the rails of the door.

Abstract: A door for a refrigerated cabinet has an insulated glass unit of rectangular shape mounted in a pair of horizontally disposed aluminum rails and a pair of vertically disposed plastic rails connected to and across the pair horizontally disposed rails. A plastic breaker is mounted on each aluminum rail and a sealing gasket of open rectangular shape is mounted in each breaker and in each plastic rail to seal against a planar surface of the refrigerated cabinet in the closed position of the door.

Abstract: The present invention pertains generally to the field of organic chemical synthesis, and in particular to certain methods for the synthesis of 8-(4-aminophenyoxy)-4H-pyrido[2,3-b]pyrazin-3-one and related compounds (denoted herein as (3)) from 4-(4-aminophenyoxy)pyridine-2,3-diamine and related compounds (denoted herein as (1)), by reaction with glyoxylic acid (denoted herein as (2)). The compounds (3) are useful in the synthesis of known anti-cancer agents, such as 1-(5-tert-butyl-2-(4-methyl-phenyl)-pyrazol-3-yl)-3-[2-fluoro-4-[(3-oxo-4H-pyrido[2,3-b]pyrazin-8-yl)oxy]phenyl]urea.