Abstract: Methods, apparatus, systems, and articles of manufacture to optimize pipeline execution are disclosed. An example apparatus includes at least one memory, machine readable instructions, and processor circuitry to execute the machine readable instructions to determine a value associated with a first location of a first pixel of a first image and a second location of a second pixel of a second image by calculating a matching cost between the first location and the second location, generate a disparity map including the value, and determine a minimum value based on the disparity map corresponding to a difference in horizontal coordinates between the first location and the second location.

Abstract: A computer-implemented method for effectively delivering notifications in data storage environments includes, receiving, by a storage controller from a host system, a request to register the host system with the storage controller to receive notifications. These notifications may be associated with a selected type of event detected by the storage controller. In certain embodiments, the selected type of event is a space-related condition associated with a particular storage resource controlled by the storage controller. The computer-implemented method registers the host system with the storage controller. In response to detecting an event of the selected type on the storage controller, the computer-implemented method transmits a notification from the storage controller to the host system to provide notice of the event. A corresponding system and computer program product are also disclosed.

Abstract: An example device includes a user interface component that implements a user interface and receives a visualization request value from user operations; an inspection database comprising an aggregation of inspection data; and a controller, comprising: a facility planning circuit that interprets a user facility visualization value in response to the visualization request value; a facility inspection data circuit that interprets the aggregation of inspection data in response to the user facility visualization value; a geographic depiction circuit that determines a geographic display boundary and a hierarchical inspection presentation for at least one industrial facility positioned within the geographic display boundary in response to the user facility visualization value and the aggregation of inspection data, and determines a user geographic display value in response to the geographic display boundary and the hierarchical inspection presentation.

Abstract: There is provided a method for mediating the flow of messages in a computer network having a mediation architecture that includes a plurality of logical nodes arranged in a logical mediation cycle. The method provides algorithms for: handing mediation tasks over between mediator nodes; reconfiguring the logical topology of the mediation architecture in response to a change request while maintaining system invariants; and refining the structure of the mediation architecture by adding whole subnetworks in place of single nodes. The method also addresses failure detection and recovery.

Abstract: A distributed mediation network and method of employing such is provided, having a plurality of different types of network module. Each module has a non-reciprocal path therethrough for network traffic and the distribution of network traffic across the network is managed by an autonomic control plane.

Abstract: There is provided a method for mediating the flow of messages in a computer network having a mediation architecture that includes a plurality of logical nodes in a cubic mediation arrangement. The method comprises handing over one or more mediation tasks between a donor mediator module and a recipient mediator module in response to a change request while maintaining system invariants.

Abstract: A distributed mediation network and method of employing such is provided, having a plurality of different types of network module. Each module has a non-reciprocal path therethrough for network traffic and the distribution of network traffic across the network is managed by an autonomic control plane.

Abstract: A distributed mediation network and method of employing such is provided, having a plurality of different types of network module. Each module has a non-reciprocal path therethrough for network traffic and the distribution of network traffic across the network is managed by an autonomic control plane.

Abstract: Biomarkers that correlate to treatment with drugs that inhibit c-met are disclosed. These biomarkers have been shown to have utility in assessing response to the compounds. The expression level of the biomarkers is reduced upon treatment with c-met inhibitor compounds, thus indicating that these biomarkers are involved in c-met activity.

Abstract: A distributed mediation network and method of employing such is provided, having a plurality of different types of network module. Each module has a non-reciprocal path therethrough for network traffic and the distribution of network traffic across the network is managed by an autonomic control plane.

Abstract: Fascines for filling ditches or smoothing other discontinuities in or on the ground to facilitate the passage of vehicles across the discontinuity are composed of inflatable members of the kind comprising an inflatable chamber configured to define a hollow tube when inflated. These tubes, or at least selected lengths thereof, are reinforced internally against deformation under applied loads, by means of additional inflatable chambers which may themselves be of hollow or “solid” form, or by means of flexible tension members tied across the interior of the tube to resist expansion of the tube cross-section in the plane perpendicular to the load.

Abstract: The invention is directed to triazolopyridazine compounds of Formula I: where R1, R5, R6, R7, R8, and A are as defined herein, the use of such compounds as protein tyrosine kinase modulators, particularly inhibitors of c-Met, and the use of such compounds to reduce or inhibit kinase activity of c-Met in a cell or a subject, and modulate c-Met expression in a cell or subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or disorders related to c-Met. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as cancers and other cell proliferative disorders.

Abstract: The invention is directed to acylhydrazones compounds of Formula I: where R1, R2 and A are as defined herein, the use of such compounds as protein tyrosine kinase modulators, particularly inhibitors of c-Met, and the use of such compounds to reduce or inhibit kinase activity of c-Met in a cell or a subject, and modulate c-Met expression in a cell or subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or disorders related to c-Met. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as cancers and other cell proliferative disorders.

Abstract: The invention relates to the discovery of triazolopyrimidine derivatives of formula (I), which have been found to exhibit inhibitory activity against the serine-tyrosine and tyrosine kinases.

Abstract: The present invention relates to the compounds of Formula I, their preparation and pharmaceutical compositions comprising them. The compounds and pharmaceutical compositions are useful, for example, for the treatment and prevention of obesity, obesity-related disorders and eating disorders.

Abstract: The present invention concerns the compounds of formula the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein m represents an integer being 0 or 1; n represents an integer being 0, 1 or 2; R1 represents C1-4alkyl, C1-4alkyl substituted with pyridinyl, phenyl, piperidinyl or piperidinyl substituted with C1-4alkyloxycarbonyl; R2 represents hydrogen or C1-4alkyl; R3 represents hydrogen or C1-4alkyl; or R2 and R3 taken together with the carbon atom to which they are attached form cyclopentyl or piperidinyl wherein said cyclopentyl or piperidinyl each independently may optionally be substituted with one, or where possible, two or three substituents each independently selected from C1-4alkyloxycarbonyl, phenylcarbonyl or —C(?NH)—NH2; R4 represents halo or C1-4alkyloxy; R5 represents Het2, C1-4alkyl substituted with one or where possible more substituents being selected from hydroxy, halo, Het3 or NR6R7, or C1-4alkyloxy substituted with one or

Abstract: The present invention concerns the compounds of formula the N-oxide forms, the pharmaceutically acceptable addition salts and the stereo-chemically isomeric forms thereof, wherein n represents an integer being 0, 1 or 2; m represents an integer being 0 or 1; R represents C1-4alkyl; R represents C1-4alkyl; R3 represents C1-4alkyl; or R2 and R3 taken together with the carbon atom to which they are attached form a C3-8cycloalkyl or Het1 wherein said C3-8cycloalkyl or Het1 each independently may optionally be substituted with C1-4alkyloxycarbonyl; R4 represents halo or C1-4alkyloxy; R5 represents C1-4alkyloxycarbonyl, —O-(mono- or di(C1-4alkyl)aminosulfonyl), C1-4alkyl substituted with one or where possible more substituent being selected from Het3 or NR6R7, C1-4alkyloxy substituted with one or where possible more substituents being selected from amino, Het4 or NR8R9; R6 and R7 are each independently selected from hydrogen, C1-4alkyl, C1-4alkyloxyC1-4alkyl, -Het5 or C1-4alkyl substituted with one or where po

Abstract: The present invention relates to immobilized N-substituted tricyclic 3-aminopyrazole compounds of Formula 1 as tools for the identification of bimolecular targets in cells of therapeutic significance, profiling the selectivity of compounds, prediction of possible related toxicities and exploration of mechanisms of action in biological systems for therapeutic indications related to compounds. These agents can be used to identify biomolecules with the potential to interact with the immobilized reagent. The identified biomolecule may be then be used as a therapeutic target, serve as a marker of drug action, or alternatively describe an untoward or toxic potential of the immobilized agent.

Abstract: A projection display system employs one or more color modifying aperture stops, such as apodizing aperture stops, to provide high contrast, balanced color and high throughput. One projection system includes a reflective liquid crystal-on-silicon light valve positioned with a polarizing beam splitter, such as a wire grid polarizing beam splitter, for each of the primary color component light paths to separately impart image information into each of the primary color components of light. A color combiner receives and combines the primary color components of light with imparted image information to provide light representing a polychromatic display image. At least one aperture stop is positioned along at least one of the primary color component light paths to balance relative intensities of the primary color components of light.

Abstract: There is provided a method for mediating the flow of messages in a computer network having a mediation architecture that includes a plurality of logical nodes in a cubic mediation arrangement. The method comprises handing over one or more mediation tasks between a donor mediator module and a recipient mediator module in response to a change request while maintaining system invariants.