Patents by Inventor Richard D. Caldwell

Richard D. Caldwell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BICYCLIC ARYL SPHINGOSINE 1-PHOSPHATE ANALOGS
    Publication number: 20180133233
    Abstract: Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphin-gosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.
    Type: Application
    Filed: October 13, 2017
    Publication date: May 17, 2018
    Inventors: Jermaine Thomas, Xiaogao Liu, Edward Yin-Shiang Lin, Guo Zhu Zheng, Bin Ma, Richard D. Caldwell, Kevin M. Guckian, Gnanasambandam Kumaravel, Arthur G. Taveras
  • 2-OXO-IMIDAZOPYRIDINES AS REVERSIBLE BTK INHIBITORS AND USES THEREOF
    Publication number: 20180051024
    Abstract: The present invention relates to imidazo pyridine compounds, and pharmaceutically acceptable compositions thereof, useful as BTK inhibitors.
    Type: Application
    Filed: August 15, 2017
    Publication date: February 22, 2018
    Inventor: Richard D. CALDWELL
  • S1P MODULATING AGENTS
    Publication number: 20180028511
    Abstract: Compounds of formula (I) or (II) can modulate the activity of S1P receptors.
    Type: Application
    Filed: July 7, 2017
    Publication date: February 1, 2018
    Inventors: Jermaine Thomas, Sha Mi, Edward Yin-Shiang Lin, Guo Zhu Zheng, Bin Ma, Richard D. Caldwell, Kevin M. Guckian, Gnanasambandam Kumaravel
  • HETEROBICYCLIC SPHINGOSINE 1-PHOSPHATE ANALOGS
    Publication number: 20180002356
    Abstract: Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.
    Type: Application
    Filed: June 13, 2017
    Publication date: January 4, 2018
    Inventors: Richard D. Caldwell, Kevin M. Guckian, Gnanasambandam Kumaravel, Wen-Cherng Lee, Edward Yin-Shiang Lin, Xiaogao Liu, Bin Ma, Daniel M. Scott, Zhan Shi, Jermaine Thomas, Arthur G. Taveras, Guo Zhu Zheng
  • Bicyclic aryl sphingosine 1-phosphate analogs
    Patent number: 9827258
    Abstract: Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphin-gosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.
    Type: Grant
    Filed: January 3, 2017
    Date of Patent: November 28, 2017
    Assignee: BIOGEN MA INC.
    Inventors: Jermaine Thomas, Xiaogao Liu, Edward Yin-Shiang Lin, Guo Zhu Zheng, Bin Ma, Richard D. Caldwell, Kevin M. Guckian, Gnanasambandam Kumaravel, Arthur G. Taveras
  • S1P modulating agents
    Patent number: 9808449
    Abstract: Compounds of formula (I) or (II) can modulate the activity of S1P receptors.
    Type: Grant
    Filed: December 23, 2015
    Date of Patent: November 7, 2017
    Assignee: BIOGEN MA INC.
    Inventors: Jermaine Thomas, Sha Mi, Edward Yin-Shiang Lin, Guo Zhu Zheng, Bin Ma, Richard D. Caldwell, Kevin Guckian, Gnanasambandam Kumaravel
  • BICYCLIC ARYL SPHINGOSINE 1-PHOSPHATE ANALOGS
    Publication number: 20170239280
    Abstract: Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.
    Type: Application
    Filed: January 3, 2017
    Publication date: August 24, 2017
    Inventors: Jermaine Thomas, Xiaogao Liu, Edward Yin-Shiang Lin, Guo Zhu Zheng, Bin Ma, Richard D. Caldwell, Kevin M. Guckian, Gnanasambandam Kumaravel, Arthur G. Taveras
  • Pyridines, pyrimidines, and pyrazines, as BTK inhibitors and uses thereof
    Patent number: 9738648
    Abstract: The present invention relates to pyridine, pyrimidine, and pyrazine compounds, and pharmaceutically acceptable compositions thereof, useful as BTK inhibitors.
    Type: Grant
    Filed: July 30, 2014
    Date of Patent: August 22, 2017
    Assignee: Merck Patent GmbH
    Inventors: Lesley Liu-Bujalski, Ngan Nguyen, Hui Qiu, Reinaldo Jones, Igor Mochalkin, Richard D. Caldwell
  • PYRIDINES, PYRIMIDINES, AND PYRAZINES, AS BTK INHIBITORS AND USES THEREOF
    Publication number: 20170226113
    Abstract: The present invention relates to pyridine, pyrimidine, and pyrazene compounds, and pharmaceutically acceptable compositions thereof, useful as BTK inhibitors.
    Type: Application
    Filed: April 27, 2017
    Publication date: August 10, 2017
    Inventors: Lesley LIU-BUJALSKI, Ngan NGUYEN, Hui QIU, Reinaldo JONES, Igor MOCHALKIN, Richard D. CALDWELL
  • Heterobicyclic sphingosine 1-phosphate analogs
    Patent number: 9708353
    Abstract: Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.
    Type: Grant
    Filed: February 12, 2015
    Date of Patent: July 18, 2017
    Assignee: BIOGEN MA INC.
    Inventors: Richard D. Caldwell, Kevin Guckian, Gnanasambandam Kumaravel, Wen-Cherng Lee, Edward Yin-Shiang Lin, Xiaogao Liu, Bin Ma, Daniel M. Scott, Zhan Shi, Jermaine Thomas, Arthur G. Taveras, Guo Zhu Zheng
  • Bicyclic aryl sphingosine 1-phosphate analogs
    Patent number: 9572824
    Abstract: Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphin-gosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.
    Type: Grant
    Filed: October 5, 2015
    Date of Patent: February 21, 2017
    Assignee: BIOGEN MA INC.
    Inventors: Jermaine Thomas, Xiaogao Liu, Edward Yin-Shiang Lin, Guo Zhu Zheng, Bin Ma, Richard D. Caldwell, Kevin M. Guckian, Gnanasambandam Kumaravel, Arthur G. Taveras
  • HETEROARYL COMPOUNDS AS BTK INHIBITORS AND USES THEREOF
    Publication number: 20170008857
    Abstract: The present invention relates to pyrimidine compounds, and pharmaceutically acceptable compositions thereof, useful as BTK inhibitors.
    Type: Application
    Filed: July 8, 2016
    Publication date: January 12, 2017
    Inventors: Hui QIU, Richard D. CALDWELL, Lesley LIU-BUJALSKI
  • HETEROARYL COMPOUNDS AS BTK INHIBITORS AND USES THEREOF
    Publication number: 20160264548
    Abstract: The present invention relates to pyridine, pyrimidine, pyrazine, and pyridazine compounds, and pharmaceutically acceptable compositions thereof, useful as BTK inhibitors.
    Type: Application
    Filed: October 21, 2014
    Publication date: September 15, 2016
    Applicant: Merck Patent GMBH
    Inventors: Hui QIU, Richard D. CALDWELL, Constantin NEAGU, Igor MOCHALKIN, Lesley LIU-BUJALSKI, Reinaldo JONES, Devon TATE, Theresa L. JOHNSON, Anna GARDBERG
  • S1P modulating agents
    Publication number: 20160263093
    Abstract: Compounds of formula (I) or (II) can modulate the activity of S1P receptors.
    Type: Application
    Filed: December 23, 2015
    Publication date: September 15, 2016
    Inventors: Jermaine Thomas, Sha Mi, Edward Yin-Shiang, Guo Zhu Zheng, Bin Ma, Richard D. Caldwell, Kevin Guckian, Gnanasambandam Kumaravel
  • ASSAYS FOR BTK INHIBITORS
    Publication number: 20160169894
    Abstract: The present invention relates to BTK occupancy assays.
    Type: Application
    Filed: December 10, 2015
    Publication date: June 16, 2016
    Inventors: Andrew BENDER, Lesley LIU-BUJALSKI, Albertina PEREIRA, Richard D. CALDWELL, Roland GRENNINGLOH, Daigen XU
  • PYRIDINES, PYRIMIDINES, AND PYRAZINES, AS BTK INHIBITORS AND USES THEREOF
    Publication number: 20160159804
    Abstract: The present invention relates to pyridine, pyrimidine, and pyrazene compounds, and pharmaceutically acceptable compositions thereof, useful as BTK inhibitors.
    Type: Application
    Filed: July 30, 2014
    Publication date: June 9, 2016
    Inventors: Lesley LIU-BUJALSKI, Ngan NGUYEN, Hui QIU, Reinaldo JONES, Igor MOCHALKIN, Richard D. CALDWELL
  • BICYCLIC ARYL SPHINGOSINE 1-PHOSPHATE ANALOGS
    Publication number: 20160129023
    Abstract: Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphin-gosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.
    Type: Application
    Filed: October 5, 2015
    Publication date: May 12, 2016
    Inventors: Jermaine Thomas, Xiaogao Liu, Edward Yin-Shiang Lin, Guo Zhu Zheng, Bin Ma, Richard D. Caldwell, Kevin M. Guckian, Gnanasambandam Kumaravel, Arthur G. Taveras
  • HETEROARYL COMPOUNDS AS BTK INHIBITORS AND USES THEREOF
    Publication number: 20160096834
    Abstract: The present invention relates to imidazo pyridine compounds, and pharmaceutically acceptable compositions thereof, useful as BTK inhibitors.
    Type: Application
    Filed: October 6, 2015
    Publication date: April 7, 2016
    Inventors: Pascale GAILLARD, Jeyaprakashnarayanan SEENISAMY, Lesley LIU-BUJALSKI, Richard D. CALDWELL, Justin POTNICK, Hui QIU, Constantin NEAGU, Reinaldo JONES, Annie Cho WON, Andreas GOUTOPOULOS, Brian A. SHERER, Theresa L. JOHNSON, Anna GARDBERG
  • Bicyclic aryl sphingosine 1-phosphate analogs
    Patent number: 9186367
    Abstract: Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphin-gosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.
    Type: Grant
    Filed: June 17, 2014
    Date of Patent: November 17, 2015
    Assignee: BOIGEN MA INC.
    Inventors: Jermaine Thomas, Xiaogao Liu, Edward Yin-Shiang Lin, Guo Zhu Zheng, Ma Bin, Richard D. Caldwell, Kevin M. Guckian, Gnanasambandam Kumaravel, Arthur G. Taveras
  • Heterobicyclic sphingosine 1-phosphate analogs
    Patent number: 9181191
    Abstract: Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.
    Type: Grant
    Filed: October 5, 2012
    Date of Patent: November 10, 2015
    Assignee: BIOGEN MA INC.
    Inventors: Richard D. Caldwell, Kevin M. Guckian, Gnanasambandam Kumaravel, Wen-Cherng Lee, Edward Yin-Shiang Lin, Xiaogao Liu, Bin Ma, Daniel M. Scott, Zhan Shi, Jermaine Thomas, Arthur G. Taveras, Guo Zhu Zheng