Patents by Inventor Richard D. DiMarchi

Richard D. DiMarchi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modified Human Four Helical Bundle Polypeptides And Their Uses
    Publication number: 20080300163
    Abstract: Modified human four helical bundle (4HB) polypeptides and uses thereof are provided.
    Type: Application
    Filed: January 28, 2005
    Publication date: December 4, 2008
    Applicant: AMBRX, INC.
    Inventors: Ho Sung Cho, Thomas O. Daniel, Richard D. DiMarchi, Anna-Maria Hays, Troy E. Wilson, Bee-Cheng Sim, David C. Litzinger
  • Modified Human Four Helical Bundle Polypeptides and Their Uses
    Publication number: 20080207877
    Abstract: Modified human four helical bundle (4HB) polypeptides and uses thereof are provided.
    Type: Application
    Filed: April 24, 2008
    Publication date: August 28, 2008
    Applicant: AMBRX, INC.
    Inventors: Ho Sung CHO, Thomas O. DANIEL, Richard D. DIMARCHI, Anna-Maria HAYS, Troy E. WILSON, Bee-Cheng SIM, David C. LITZINGER
  • Modified Human Four Helical Bundle Polypeptides and Their Uses
    Publication number: 20080161539
    Abstract: Modified human four helical bundle (4HB) polypeptides and uses thereof are provided.
    Type: Application
    Filed: October 18, 2007
    Publication date: July 3, 2008
    Applicant: AMBRX, INC.
    Inventors: Ho Sung CHO, Thomas O. DANIEL, Richard D. DIMARCHI, Anna-Maria HAYS, Troy E. WILSON, Bee-Cheng SIM, David C. LITZINGER
  • Modified Human Four Helical Bundle Polypeptides and Their Uses
    Publication number: 20080146781
    Abstract: Modified human four helical bundle (4HB) polypeptides and uses thereof are provided.
    Type: Application
    Filed: October 18, 2007
    Publication date: June 19, 2008
    Applicant: AMBRX, INC.
    Inventors: Ho Sung CHO, Thomas O. DANIEL, Richard D. DIMARCHI, Anna-Maria HAYS, Troy E. WILSON, Bee-Cheng SIM, David C. LITZINGER
  • Modified Human Plasma Polypeptide or Fc Scaffolds and Their Uses
    Publication number: 20080125574
    Abstract: Modified human plasma polypeptides or Fc and uses thereof are provided.
    Type: Application
    Filed: October 29, 2007
    Publication date: May 29, 2008
    Applicant: AMBRX, INC.
    Inventors: Joseph SHEFFER, Thea NORMAN, Richard D. DIMARCHI, Anna-Maria A. HAYS PUTNAM, Feng TIAN, Stephanie CHU, Denise KRAWITZ, Ho Sung CHO
  • Modified Human Plasma Polypeptide or Fc Scaffolds and Their Uses
    Publication number: 20080113411
    Abstract: Modified human plasma polypeptides or Fc and uses thereof are provided.
    Type: Application
    Filed: October 29, 2007
    Publication date: May 15, 2008
    Applicant: AMBRX, INC.
    Inventors: Joseph SHEFFER, Thea NORMAN, Richard D. DIMARCHI, Anna-Maria A. HAYS PUTNAM, Feng TIAN, Stephanie CHU, Denise KRAWITZ, Ho Sung CHO
  • Modified Human Plasma Polypeptide or Fc Scaffolds and Their Uses
    Publication number: 20080113412
    Abstract: Modified human plasma polypeptides or Fc and uses thereof are provided.
    Type: Application
    Filed: October 29, 2007
    Publication date: May 15, 2008
    Applicant: AMBRX, INC.
    Inventors: Joseph SHEFFER, Thea NORMAN, Richard D. DIMARCHI, Anna-Maria A. HAYS PUTNAM, Feng TIAN, Stephanie CHU, Denise KRAWITZ, Ho Sung CHO
  • Use of GLP-1 analogs and derivatives administered peripherally in regulation of obesity
    Patent number: 6191102
    Abstract: This invention relates the use of glucagon-like peptides such as GLP-1, a GLP-1 analog, or a GLP-1 derivative in methods and compositions for reducing body weight.
    Type: Grant
    Filed: October 30, 1997
    Date of Patent: February 20, 2001
    Assignee: Eli Lilly and Company
    Inventors: Richard D. DiMarchi, Suad Efendic
  • Anti-obesity proteins
    Patent number: 5851995
    Abstract: The present invention provides anti-obesity proteins, which when administered to a patient regulate fat tissue. Accordingly, such agents allow patients to overcome their obesity handicap and live normal lives with much reduced risk for type II diabetes, cardiovascular disease and cancer.
    Type: Grant
    Filed: August 4, 1997
    Date of Patent: December 22, 1998
    Assignee: Eli Lilly and Company
    Inventors: Margret B. Basinski, Richard D. DiMarchi, David B. Flora, William F. Heath, Jr., James A. Hoffmann, Brigitte E. Schoner, James E. Shields, David L. Smiley
  • Anti-obesity proteins
    Patent number: 5719266
    Abstract: The present invention provides anti-obesity proteins, which when administered to a patient regulate fat tissue. Accordingly, such agents allow patients to overcome their obesity handicap and live normal lives with much reduced risk for type II diabetes, cardiovascular disease and cancer.
    Type: Grant
    Filed: March 17, 1995
    Date of Patent: February 17, 1998
    Assignee: Eli Lilly and Company
    Inventors: Richard D. DiMarchi, Ronald N. Hermeling, James A. Hoffmann
  • Process for preparing insulin analogs
    Patent number: 5700662
    Abstract: Recombinant processes for preparing insulin analogs modified at position 29 of the B-chain and, optionally, at other positions are claimed. The analogs produced using the claimed processes have modified physico-chemical properties and are useful in treating hyperglycemia.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: December 23, 1997
    Assignee: Eli Lilly and Company
    Inventors: Ronald E. Chance, Richard D. DiMarchi, Bruce H. Frank, James E. Shields
  • Anti-obesity proteins
    Patent number: 5691309
    Abstract: The present invention provides anti-obesity proteins, which when administered to a patient regulate fat tissue. Accordingly, such agents allow patients to overcome their obesity handicap and live normal lives with much reduced risk for type II diabetes, cardiovascular disease and cancer.
    Type: Grant
    Filed: February 6, 1995
    Date of Patent: November 25, 1997
    Assignee: Eli Lilly and Company
    Inventors: Margret B. Basinski, Richard D. DiMarchi, David B. Flora, William F. Heath, Jr., James A. Hoffmann, Brigitte E. Schoner, James E. Shields, David L. Smiley
  • IGF-1 superagonists
    Patent number: 5622932
    Abstract: The instant invention provides two-chain IGF-1 superagonists which are derivatives of the naturally occurring single-chain IGF-1 having an abbreviated C domain. The invention also provides synthetic and semi-synthetic DNA sequences, recombinant DNA vectors and transformed host cells useful in the recombinant production of these analogs. The invention also provides pharmaceutical formulations comprising these IGF-1 analogs. The invention also provides methods of using these analogs in a variety of therapeutic applications. The instant invention provides IGF-1 analogs of the formula:BC.sup.n,A (1)wherein:B is the B domain of IGF-1 or a functional analog thereof,C is the C domain of IGF-1 or a functional analog thereof,n is the number of amino acids in the C domain and is from about 6 to about 12, andA is the A domain of IGF-1 or a functional analog thereof.
    Type: Grant
    Filed: May 5, 1995
    Date of Patent: April 22, 1997
    Assignee: Eli Lilly and Company
    Inventors: Richard D. DiMarchi, Li Fan, Harlan B. Long
  • Anti-obesity proteins
    Patent number: 5605886
    Abstract: The present invention provides anti-obesity proteins, which when administered to a patient regulate fat tissue. Accordingly, such agents allow patients to overcome their obesity handicap and live normal lives with much reduced risk for type II diabetes, cardiovascular disease and cancer.
    Type: Grant
    Filed: May 17, 1995
    Date of Patent: February 25, 1997
    Assignee: Eli Lilly and Company
    Inventors: Margret B. Basinski, Richard D. DiMarchi, David B. Flora, William F. Heath, Jr., James A. Hoffmann, Brigitte E. Schoner, James E. Shields, David L. Smiley
  • Anti-obesity proteins
    Patent number: 5594104
    Abstract: The present invention provides anti-obesity proteins, which when administered to a patient regulate fat tissue. Accordingly, such agents allow patients to overcome their obesity handicap and live normal lives with much reduced risk for type II diabetes, cardiovascular disease and cancer.
    Type: Grant
    Filed: February 6, 1995
    Date of Patent: January 14, 1997
    Assignee: Eli Lilly and Company
    Inventors: Margret B. Basinski, Richard D. DiMarchi, David B. Flora, William F. Heath, Jr., James A. Hoffmann, Brigitte E. Schoner, James E. Shields, David L. Smiley
  • Anti-obesity proteins
    Patent number: 5580954
    Abstract: The present invention provides anti-obesity proteins, which when administered to a patient regulate fat tissue. Accordingly, such agents allow patients to overcome their obesity handicap and live normal lives with much reduced risk for type II diabetes, cardiovascular disease and cancer.
    Type: Grant
    Filed: January 31, 1995
    Date of Patent: December 3, 1996
    Assignee: Eli Lilly and Company
    Inventors: Richard D. DiMarchi, David B. Flora, William F. Heath, Jr., James A. Hoffmann, James E. Shields, David L. Smiley
  • Anti-obesity proteins
    Patent number: 5574133
    Abstract: The present invention provides anti-obesity proteins, which when administered to a patient regulate fat tissue. Accordingly, such agents allow patients to overcome their obesity handicap and live normal lives with much reduced risk for type II diabetes, cardiovascular disease and cancer.
    Type: Grant
    Filed: January 31, 1995
    Date of Patent: November 12, 1996
    Assignee: Eli Lilly and Company
    Inventors: Richard D. DiMarchi, David B. Flora, William F. Heath, Jr., James A. Hoffmann, James E. Shields, David L. Smiley
  • Anti-obesity proteins
    Patent number: 5569744
    Abstract: The present invention provides anti-obesity proteins, which when administered to a patient regulate fat tissue. Accordingly, such agents allow patients to overcome their obesity handicap and live normal lives with much reduced risk for type II diabetes, cardiovascular disease and cancer.
    Type: Grant
    Filed: February 6, 1995
    Date of Patent: October 29, 1996
    Assignee: Eli Lilly and Company
    Inventors: Margret B. Basinski, Richard D. DiMarchi, David B. Flora, William F. Heath, Jr., James A. Hoffmann, Brigitte E. Schoner, James E. Shields, David L. Smiley
  • Anti-obesity proteins
    Patent number: 5569743
    Abstract: The present invention provides anti-obesity proteins, which when administered to a patient regulate fat tissue. Accordingly, such agents allow patients to overcome their obesity handicap and live normal lives with much reduced risk for type II diabetes, cardiovascular disease and cancer.
    Type: Grant
    Filed: January 31, 1995
    Date of Patent: October 29, 1996
    Assignee: Eli Lilly and Company
    Inventors: Richard D. DiMarchi, David B. Flora, William F. Heath, Jr., James A. Hoffman, James E. Shields, David L. Smiley
  • Anti-obesity proteins
    Patent number: 5567803
    Abstract: The present invention provides anti-obesity proteins, which when administered to a patient regulate fat tissue. Accordingly, such agents allow patients to overcome their obesity handicap and live normal lives with much reduced risk for type II diabetes, cardiovascular disease and cancer.
    Type: Grant
    Filed: February 6, 1995
    Date of Patent: October 22, 1996
    Assignee: Eli Lilly and Company
    Inventors: Margret Basinski, Richard D. DiMarchi, David B. Flora, William F. Heath, Jr., James A. Hoffmann, Brigitte E. Schoner, James E. Shields, David L. Smiley