Patents by Inventor Richard D. Kopke
Richard D. Kopke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230157980Abstract: Disclosed here is a method of alleviating negative effects of cochlear implant surgery in a subject in need thereof comprising administering effective amounts of 2,4-disulfonyl ?-phenyl tertiary butyl nitrone (2,4-DSPBN) or a pharmaceutically acceptable salt thereof and N-acetylcysteine (NAC) or a pharmaceutically acceptable salt thereof to a subject prior to, during, and/or after undergoing cochlear implant surgery.Type: ApplicationFiled: September 11, 2019Publication date: May 25, 2023Applicant: HOUGH EAR INSTITUTEInventor: Richard D. KOPKE
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Publication number: 20210252038Abstract: The present disclosure relates to compositions and methods for the regeneration and/or restoration of hair cells utilizing a composition or an agent that decreases expression of a gene in a tissue of the inner ear and a second agent.Type: ApplicationFiled: April 26, 2021Publication date: August 19, 2021Applicant: Hough Ear InstituteInventors: Matthew B. WEST, Richard D. KOPKE
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Patent number: 11013752Abstract: The present disclosure relates to compositions and methods for the regeneration and/or restoration of hair cells utilizing a composition or an agent that decreases expression of a gene in a tissue of the inner ear and a second agent.Type: GrantFiled: June 2, 2017Date of Patent: May 25, 2021Assignee: HOUGH EAR INSTITUTEInventors: Matthew B. West, Richard D. Kopke
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Publication number: 20210137861Abstract: Disclosed here is a method for reducing accumulated pathologic Tau proteins in a subject in need thereof, comprising administering to the subject an effective amount of 2,4-disulfonyl ?-phenyl tertiary butyl nitrone (2,4-DSPBN) or a pharmaceutically acceptable salt thereof. The method may further comprise administrating N-acetylcysteine (NAC) to the subject in combination with 2,4-DSPBN.Type: ApplicationFiled: May 1, 2019Publication date: May 13, 2021Applicant: HOUGH EAR INSTITUTEInventor: Richard D. KOPKE
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Publication number: 20210069354Abstract: Disclosed here is a method of transporting a therapeutic or diagnostic agent across a blood-brain barrier or a blood-cochlear barrier or a blood-cerebrospinal fluid barrier of a subject, comprising administering to a subject an amount of a therapeutic and/or diagnostic agent, along with an amount of 2,4-disulfonyl a-phenyl tertiary butyl nitrone (2,4-DSPBN), said therapeutic and/or diagnostic agent being characterized as being unable or poorly able, in the absence of said amount of 2,4-DSPBN, to cross the blood-brain barrier or the blood-cochlear barrier or the blood-cerebrospinal fluid barrier of said subject.Type: ApplicationFiled: November 18, 2020Publication date: March 11, 2021Inventors: Richard D. Kopke, Rheal A. Towner
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Publication number: 20200164021Abstract: Disclosed here is a method for enhancing synaptogenesis and/or neuritogenesis, reducing neurodegeneration, and/or reducing accumulation or aggregation of Tau proteins in a subject suffering from cochlear synaptopathy or vestibular synaptopathy or a central nervous system disease or condition, comprising administering to said subject in need thereof an effective amount of 2,4-disulfonyl ?-phenyl tertiary butyl nitrone (2,4-DSPBN) or a pharmaceutically acceptable salt thereof. The method may further comprise administrating N-acetylcysteine (NAC) to the subject.Type: ApplicationFiled: January 30, 2020Publication date: May 28, 2020Applicant: HOUGH EAR INSTITUTEInventors: Richard D. Kopke, Wei Li
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Patent number: 10576125Abstract: Disclosed here is a method for enhancing synaptogenesis and/or neuritogenesis, reducing neurodegeneration, and/or reducing accumulation or aggregation of Tau proteins in a subject suffering from cochlear synaptopathy or vestibular synaptopathy or a central nervous system disease or condition, comprising administering to said subject in need thereof an effective amount of 2,4-disulfonyl ?-phenyl tertiary butyl nitrone (2,4-DSPBN) or a pharmaceutically acceptable salt thereof. The method may further comprise administrating N-acetylcysteine (NAC) to the subject.Type: GrantFiled: October 27, 2017Date of Patent: March 3, 2020Assignee: Hough Ear InstituteInventors: Richard D. Kopke, Wei Li
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Patent number: 10111843Abstract: The treatment options for treating blast-induced and noise-induced traumatic brain injury and tinnitus are limited. Thus, the current invention provides methods for treating traumatic brain injury and tinnitus. The methods involve administering a pharmaceutically effective amount of a composition comprising 2,4-disulfonyl ?-phenyl tertiary butyl nitrone and N-acetylcysteine (NAC).Type: GrantFiled: June 23, 2017Date of Patent: October 30, 2018Assignees: Hough Ear Institute, Oklahoma Medical Research FoundationInventors: Richard D. Kopke, Robert A. Floyd, Rheal Towner
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Publication number: 20180256756Abstract: Disclosed here is a method of transporting a therapeutic or diagnostic agent across a blood-brain barrier or a blood-cochlear barrier or a blood-cerebrospinal fluid barrier of a subject, comprising administering to a subject an amount of a therapeutic and/or diagnostic agent, along with an amount of 2,4-disulfonyl a-phenyl tertiary butyl nitrone (2,4-DSPBN), said therapeutic and/or diagnostic agent being characterized as being unable or poorly able, in the absence of said amount of 2,4-DSPBN, to cross the blood-brain barrier or the blood-cochlear barrier or the blood-cerebrospinal fluid barrier of said subject.Type: ApplicationFiled: September 14, 2016Publication date: September 13, 2018Applicants: Oklahoma Medical Research Foundation, Hough Ear InstituteInventors: Richard D. KOPKE, Rheal A. TOWNER
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Patent number: 10022346Abstract: The treatment options for treating blast-induced and noise-induced traumatic brain injury and tinnitus are limited. Thus, the current invention provides methods for treating traumatic brain injury and tinnitus. The methods involve administering a pharmaceutically effective amount of a composition comprising 2,4-disulfonyl ?-phenyl tertiary butyl nitrone and N-acetylcysteine (NAC).Type: GrantFiled: January 27, 2017Date of Patent: July 17, 2018Assignees: Hough Ear Institute, Oklahoma Medical Research FoundationInventors: Richard D. Kopke, Robert A. Floyd, Rheal Towner
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Publication number: 20180117115Abstract: Disclosed here is a method for enhancing synaptogenesis and/or neuritogenesis, reducing neurodegeneration, and/or reducing accumulation or aggregation of Tau proteins in a subject suffering from cochlear synaptopathy or vestibular synaptopathy or a central nervous system disease or condition, comprising administering to said subject in need thereof an effective amount of 2,4-disulfonyl ?-phenyl tertiary butyl nitrone (2,4-DSPBN) or a pharmaceutically acceptable salt thereof. The method may further comprise administrating N-acetylcysteine (NAC) to the subject.Type: ApplicationFiled: October 27, 2017Publication date: May 3, 2018Applicant: HOUGH EAR INSTITUTEInventors: Richard D. KOPKE, Wei Li
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Publication number: 20170348346Abstract: The present disclosure relates to compositions and methods for the regeneration and/or restoration of hair cells utilizing a composition or an agent that decreases expression of a gene in a tissue of the inner ear and a second agent.Type: ApplicationFiled: June 2, 2017Publication date: December 7, 2017Applicant: Hough Ear InstituteInventors: Matthew B. WEST, Richard D. KOPKE
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Publication number: 20170281583Abstract: The treatment options for treating blast-induced and noise-induced traumatic brain injury and tinnitus are limited. Thus, the current invention provides methods for treating traumatic brain injury and tinnitus. The methods involve administering a pharmaceutically effective amount of a composition comprising 2,4-disulfonyl ?-phenyl tertiary butyl nitrone and N-acetylcysteine (NAC).Type: ApplicationFiled: June 23, 2017Publication date: October 5, 2017Applicants: HOUGH EAR INSTITUTE, OKLAHOMA MEDICAL RESEARCH FOUNDATIONInventors: Richard D. KOPKE, Robert A. FLOYD, Rheal TOWNER
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Patent number: 9732343Abstract: A composition and method for replacement and regeneration of hair cells of the inner ear is provided. The composition comprises an active agent in an amount effective to decrease Hes1 gene expression in a tissue of the inner ear. The active agent can be short interfering RNA (siRNA) molecules encapsulated in a biodegradable nanoparticle. The method involves administering a solution to the inner ear where the solution contains an active agent in an amount effective to decrease Hes1 gene expression.Type: GrantFiled: July 20, 2015Date of Patent: August 15, 2017Assignee: HOUGH EAR INSTITUTEInventor: Richard D. Kopke
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Publication number: 20170224635Abstract: The current invention provides methods and compositions for treating sensorineural hearing loss including but not limited to acute acoustic trauma (AAT). The composition 2,4-disulfonyl ?-phenyl tertiary butyl nitrone and N-acetylcysteine (NAC). Preferably, the compositions for treating AAT will be administered orally. However, other methods which deliver the compositions for treating AAT systemically to the body should work equally well.Type: ApplicationFiled: April 24, 2017Publication date: August 10, 2017Applicants: Hough Ear Institute, OKLAHOMA MEDICAL RESEARCH FOUNDATIONInventors: Richard D. Kopke, Robert A. Floyd
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Publication number: 20170202797Abstract: The treatment options for treating blast-induced and noise-induced traumatic brain injury and tinnitus are limited. Thus, the current invention provides methods for treating traumatic brain injury and tinnitus. The methods involve administering a pharmaceutically effective amount of a composition comprising 2,4-disulfonyl ?-phenyl tertiary butyl nitrone and N-acetylcysteine (NAC).Type: ApplicationFiled: January 27, 2017Publication date: July 20, 2017Applicants: HOUGH EAR INSTITUTE, OKLAHOMA MEDICAL RESEARCH FOUNDATIONInventors: Richard D. KOPKE, Robert A. FLOYD, Rheal TOWNER
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Patent number: 9642823Abstract: The treatment options for treating blast-induced and noise-induced traumatic brain injury and tinnitus are limited. Thus, the current invention provides methods for treating traumatic brain injury and tinnitus. The methods involve administering a pharmaceutically effective amount of a composition comprising 2,4-disulfonyl ?-phenyl tertiary butyl nitrone and N-acetylcysteine (NAC).Type: GrantFiled: February 18, 2016Date of Patent: May 9, 2017Assignees: Hough Ear Institute, Oklahoma Medical Research FoundationInventors: Richard D. Kopke, Robert A. Floyd, Rheal Towner
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Publication number: 20160158173Abstract: The treatment options for treating blast-induced and noise-induced traumatic brain injury and tinnitus are limited. Thus, the current invention provides methods for treating traumatic brain injury and tinnitus. The methods involve administering a pharmaceutically effective amount of a composition comprising 2,4-disulfonyl ?-phenyl tertiary butyl nitrone and N-acetylcysteine (NAC).Type: ApplicationFiled: February 18, 2016Publication date: June 9, 2016Applicants: HOUGH EAR INSTITUTE, OKLAHOMA MEDICAL RESEARCH FOUNDATIONInventors: Richard D. KOPKE, Robert A. FLOYD, Rheal TOWNER
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Publication number: 20160090594Abstract: A composition and method for replacement and regeneration of hair cells of the inner ear is provided. The composition comprises an active agent in an amount effective to decrease Hes1 gene expression in a tissue of the inner ear. The active agent can be short interfering RNA (siRNA) molecules encapsulated in a biodegradable nanoparticle. The method involves administering a solution to the inner ear where the solution contains an active agent in an amount effective to decrease Hes1 gene expression.Type: ApplicationFiled: July 20, 2015Publication date: March 31, 2016Applicant: Hough Ear InstituteInventor: RICHARD D. KOPKE
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Patent number: 9289404Abstract: The treatment options for treating blast-induced and noise-induced traumatic brain injury and tinnitus are limited. Thus, the current invention provides methods for treating traumatic brain injury and tinnitus. The methods involve administering a pharmaceutically effective amount of a composition comprises 2,4-disulfonyl ?-phenyl tertiary butyl nitrone and N-acetylcysteine (NAC).Type: GrantFiled: February 3, 2012Date of Patent: March 22, 2016Assignees: HOUGH EAR INSTITUTE, OKLAHOMA MEDICAL RESEARCH FOUNDATIONInventors: Richard D. Kopke, Robert A. Floyd, Rheal Towner