Patents by Inventor Richard D. Tillyer

Richard D. Tillyer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process of preparing phenyl heterocycles useful as COX-2 inhibitors
    Patent number: 5840924
    Abstract: The invention encompasses a process for making compounds of Formula I useful in the treatment of inflammation and other cyclooxygenase-2 mediated diseases.
    Type: Grant
    Filed: June 16, 1997
    Date of Patent: November 24, 1998
    Assignee: Merck & Co., Inc.
    Inventors: Richard Desmond, Ulf H. Dolling, Lisa F. Frey, Richard D. Tillyer, David M. Tschaen
  • Synthesis of .alpha.-chloro or fluoro ketones
    Patent number: 5786515
    Abstract: A simple, high yielding synthesis of a-chloro ketones is described, involving acylation of Grignard and organolithium reagents with N-methoxy-N-methylchloroacetamide. The efficiency of the process is further enhanced by recycling N,O-dimethylhydroxylamine.
    Type: Grant
    Filed: August 30, 1996
    Date of Patent: July 28, 1998
    Assignee: Merck & Co., Inc.
    Inventors: Ulf H. Dolling, Lisa F. Frey, Richard D. Tillyer, David M. Tschaen
  • Enantioselective synthesis of cyclic amino alcohols
    Patent number: 5574186
    Abstract: There is disclosed a novel process for the enantioselective synthesis of chiral amino alcohols from keto oxime ethers, which are derived from cyclic ketones, via catalytic asymmetric reduction, employing oxazaborolidine-borane complex (OAB-BH.sub.3). In this catalytic reduction process two chiral centers are created in a single step with high levels of stereoselectivity.
    Type: Grant
    Filed: March 8, 1995
    Date of Patent: November 12, 1996
    Assignee: Merck & Co., Inc.
    Inventors: Charles Boudreau, Richard D. Tillyer, David M. Tschaen