Patents by Inventor Richard Daifuku

Richard Daifuku has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Silylated pyrimidine prodrugs and methods of their use
    Patent number: 10479807
    Abstract: Silylated-pyrimidine prodrugs, compositions that include the silylated-pyrimidine prodrugs, methods for making the silylated-pyrimidine prodrugs and compositions, and methods for treating cancer using the silylated-pyrimidine prodrugs and compositions.
    Type: Grant
    Filed: October 8, 2015
    Date of Patent: November 19, 2019
    Assignee: Epigenetics Phrama LLC
    Inventors: Richard Daifuku, Dmitri S. Sergueev
  • METHOD OF TREATMENT OF TP53 WILD-TYPE TUMORS WITH 2',2'-DIFLUORO-5-AZA-2'-DEOXYCYTIDINE OR PRODRUGS THEREOF
    Publication number: 20190054103
    Abstract: This disclosure provides methods and strategies for inhibiting the growth of TP53 wild-type cancer cells, comprising contacting the cell with 2?,2?-difluoro-5-aza-2?-deoxycytidine or a 2?,2?-difluoro-5-aza-2?-deoxycytidine prodrug. Also provided are related methods for treating a cancer characterized by having wild-type TP53 in a subject in need thereof.
    Type: Application
    Filed: February 24, 2017
    Publication date: February 21, 2019
    Inventor: Richard DAIFUKU
  • Vitamin E-nucleoside prodrugs
    Patent number: 10071112
    Abstract: The present disclosure describes nucleoside and nucleoside analogs that are conjugated to a vitamin E derivative via a phosphate ester or a phosphoramidate linkage. The nucleoside or nucleoside analogs can provide enhanced therapeutic activity (e.g., antiproliferative activity against tumor cells) and/or greater chemical stability in aqueous solutions.
    Type: Grant
    Filed: October 8, 2015
    Date of Patent: September 11, 2018
    Assignee: Epigenetics Pharma LLC
    Inventor: Richard Daifuku
  • Silylated Pyrimidine Prodrugs And Methods Of Their Use
    Publication number: 20170305941
    Abstract: Silylated-pyrimidine prodrugs, compositions that include the silylated-pyrimidine prodrugs, methods for making the silylated-pyrimidine prodrugs and compositions, and methods for treating cancer using the silylated-pyrimidine prodrugs and compositions.
    Type: Application
    Filed: October 8, 2015
    Publication date: October 26, 2017
    Inventors: Richard Daifuku, Dmitri S. Sergueev
  • Vitamin E-Nucleoside Prodrugs
    Publication number: 20170298088
    Abstract: The present disclosure describes nucleoside and nucleoside analogues that are conjugated to a vitamin E derivative via a phosphate ester or a phosphoramidate linkage. The nucleoside or nucleoside analogues can provide enhanced therapeutic activity (e.g., antiproliferative activity against tumor cells) and/or greater chemical stability in aqueous solutions.
    Type: Application
    Filed: October 8, 2015
    Publication date: October 19, 2017
    Inventor: Richard Daifuku
  • Fluorinated pyrimidine analogs and methods of use thereof
    Patent number: 9493500
    Abstract: The present invention provides fluorinated 5-aza-2?-deoxycytidine compounds, such as 2?,2?-difluoro-5-aza-2?-deoxycytidine, compositions that include the compounds, methods for making the compounds, and methods for inhibiting DNA methyltransferase, treating solid tumors, and treating hematologic cancers by administering the compounds.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: November 15, 2016
    Inventor: Richard Daifuku
  • FLUORINATED PYRIMIDINE ANALOGS AND METHODS OF USE THEREOF
    Publication number: 20140024612
    Abstract: Fluorinated pyrimidine analog compounds, compositions that include the fluorinated pyrimidine analog compounds, methods for making the fluorinated pyrimidine analog compounds, and methods for inhibiting DNA methyltransferase, treating solid tumors, and treating hematologic cancers by administering the fluorinated pyrimidine analog compounds.
    Type: Application
    Filed: March 15, 2013
    Publication date: January 23, 2014
    Applicant: OncoGenex Pharmaceuticals, Inc.
    Inventors: Richard Daifuku, Anna Gall, Dmitri S. Sergueev
  • Prodrugs of heteroaryl compounds
    Patent number: 8324379
    Abstract: The present invention provides hydrophobic prodrugs of bases, nucleosides, and nucleotides as well as methods of using the prodrugs as antiviral and anti-cancer chemotherapeutic agents.
    Type: Grant
    Filed: May 16, 2011
    Date of Patent: December 4, 2012
    Assignee: Koronis Pharmaceuticals, Inc.
    Inventors: Richard Daifuku, Alexander Gall, Dmitri Sergueev, Dina Sologub, Kevin Harris
  • Prodrugs of Heteroaryl Compounds
    Publication number: 20110224434
    Abstract: The present invention provides hydrophobic prodrugs of bases, nucleosides, and nucleotides as well as methods of using the prodrugs as antiviral and anti-cancer chemotherapeutic agents.
    Type: Application
    Filed: May 16, 2011
    Publication date: September 15, 2011
    Applicant: Koronis Phamaceuticals, Incorporated
    Inventors: Richard Daifuku, Alexander Gall, Dmitri Sergueev, Dina Sologub, Kevin Harris
  • Prodrugs of heteroaryl compounds
    Patent number: 7982034
    Abstract: The present invention provides hydrophobic prodrugs of bases, nucleosides, and nucleotides as well as methods of using the prodrugs as antiviral and anti-cancer chemotherapeutic agents.
    Type: Grant
    Filed: April 7, 2009
    Date of Patent: July 19, 2011
    Assignee: Koronis Pharmaceuticals, Incorporated
    Inventors: Richard Daifuku, Alexander Gall, Dmitri Sergueev, Dina Sologub, Kevin Harris
  • Mutagenic Nucleoside Analogs for the Treatment of Viral Disease
    Publication number: 20100279968
    Abstract: The present invention relates to methods of treating viral disease using mutagenic nucleoside analogs.
    Type: Application
    Filed: December 27, 2006
    Publication date: November 4, 2010
    Applicant: Koronis Pharmaceuticals, Inc.
    Inventors: Ling Li, Alexander Gall, Richard Daifuku
  • 1,3,5-triazines for treatment of viral diseases
    Patent number: 7772197
    Abstract: The present invention provides compounds and methods for treatment of viral diseases and cancer.
    Type: Grant
    Filed: September 24, 2003
    Date of Patent: August 10, 2010
    Assignee: 1,3,5-Triazines for Treatment of Viral Diseases
    Inventors: Richard Daifuku, Alexander Gall, Dmitri Sergueev
  • Mutagenic nucleoside analogs for the treatment of viral disease
    Patent number: 7648967
    Abstract: The present invention relates to methods of treating viral disease using mutagenic nucleoside analogs. In particular, the invention provides isoguanosine nucleosides and derivatives thereof as well a method of increasing the mutation rate of a virus such as bovine viral diarrhea virus (BVDV) and hepatitis C virus (HCV).
    Type: Grant
    Filed: February 13, 2006
    Date of Patent: January 19, 2010
    Assignee: Koronis Pharmaceuticals, Incorporated
    Inventors: Ling Li, Alexander Gall, Richard Daifuku
  • 1,3,5-triazines for treatment of viral diseases
    Patent number: 7642247
    Abstract: The present invention provides compounds and methods for treatment of viral diseases and cancer.
    Type: Grant
    Filed: February 6, 2007
    Date of Patent: January 5, 2010
    Assignee: Koronis Pharmaceuticals, Incorporated
    Inventors: Richard Daifuku, Alexander Gall, Dmitri Sergueev
  • Prodrugs of heteroaryl compounds
    Patent number: 7589092
    Abstract: The present invention provides hydrophobic prodrugs of bases, nucleosides, and nucleotides as well as methods of using the prodrugs as antiviral and anti-cancer chemotherapeutic agents.
    Type: Grant
    Filed: December 27, 2006
    Date of Patent: September 15, 2009
    Assignee: Koronis Pharmaceuticals, Incorporated
    Inventors: Richard Daifuku, Alexander Gall, Dmitri Sergueev, Dina Sologub, Kevin Harris
  • PRODRUGS OF HETEROARYL COMPOUNDS
    Publication number: 20090209505
    Abstract: The present invention provides hydrophobic prodrugs of bases, nucleosides, and nucleotides as well as methods of using the prodrugs as antiviral and anti-cancer chemotherapeutic agents.
    Type: Application
    Filed: April 7, 2009
    Publication date: August 20, 2009
    Applicant: Koronis Pharmaceuticals, Incorporated
    Inventors: Richard Daifuku, Alexander Gall, Dmitri Sergueev, Dina Sologub, Kevin Harris
  • PRODRUGS OF HETEROARYL COMPOUNDS
    Publication number: 20090192099
    Abstract: The present invention provides hydrophobic prodrugs of bases, nucleosides, and nucleotides as well as methods of using the prodrugs as antiviral and anti-cancer chemotherapeutic agents.
    Type: Application
    Filed: March 30, 2009
    Publication date: July 30, 2009
    Applicant: Koronis Pharmaceuticals, Incorporated
    Inventors: Richard Daifuku, Alexander Gall, Dmitri Sergueev, Dina Sologub, Kevin Harris
  • PRODRUGS OF HETEROARYL COMPOUNDS
    Publication number: 20080249097
    Abstract: The present invention provides hydrophobic prodrugs of bases, nucleosides, and nucleotides as well as methods of using the prodrugs as antiviral and anti-cancer chemotherapeutic agents.
    Type: Application
    Filed: December 27, 2006
    Publication date: October 9, 2008
    Applicant: Koronis Pharmaceuticals, Incorporation
    Inventors: Richard Daifuku, Alexander Gall, Dmitri Sergueev, Dina Sologub, Kevin Harris
  • Mutagenic Heterocycles
    Publication number: 20080033172
    Abstract: The present invention provides compounds as well as methods of using the compounds as antiviral and anti-cancer chemotherapeutic agents.
    Type: Application
    Filed: December 10, 2004
    Publication date: February 7, 2008
    Applicant: Koronis Pharmaceuticals, Incorporated
    Inventors: Richard Daifuku, Alexander Gall, Dmitri Sergueev
  • MUTAGENIC HETEROCYCLES
    Publication number: 20080009496
    Abstract: The present invention provides compounds as well as methods of using the compounds as antiviral and anti-cancer chemotherapeutic agents.
    Type: Application
    Filed: December 27, 2006
    Publication date: January 10, 2008
    Applicant: Koronis Pharmaceuticals, Inc.
    Inventors: Richard Daifuku, Alexander Gall, Dmitri Sergueev