Patents by Inventor Richard David Newcomb

Richard David Newcomb has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Malathion carboxylesterase
    Patent number: 7091025
    Abstract: The present invention provides an isolated DNA molecule encoding Malathion Carboxylesterase capable of hydrolysing at least one organophosphate selected from the group consisting of carboxylester organophosphates and dimethyloxon organophosphates. The DNA molecule comprises a nucleotide sequence having at least 60%, preferably at least 80% and more preferably at least 95% homology with Lc?E 7, in which the protein encoded by the DNA molecule differs from E 3 at least in the substitution of Trip at position 251 with an amino acid selected from the group consisting of Leu, Ser, Ala, Ile, Val, Thr, Cys, Met and Gly. The preferred substituents are Leu and Ser.
    Type: Grant
    Filed: February 6, 2001
    Date of Patent: August 15, 2006
    Assignee: Commonwealth Scientific and Industrial Research Organisation
    Inventors: Robyn Joyce Russell, Richard David Newcomb, Peter Malcolm Campbell, Geoffrey Charles de Quetteville Robin, Charles Claudianos, Kerrie-Anne Smyth, Thomas Mark Boyce, John Graham Oakeshott, Jeremy Colin Brownlie
  • Malathion carboxylesterase
    Publication number: 20030143711
    Abstract: The present invention provides an isolated DNA molecule encoding Malathion Carboxylesterase capable of hydrolysing at least one organophosphate selected from the group consisting of carboxylester organophosphates and dimethylol organophosphates. The DNA molecule comprises a nucleotide sequence having at least 60%, preferably at least 80% and more preferably at least 95% homology with Lc?E 7, in which the protein encoded by the DNA molecule differs from E 3 at least in the substitution of Trip at position 251 with an amino acid selected from the group consisting of Leu, Ser, Ala, Ile, Val, Thr, Cys, Met and Gly. The preferred substituents are Leu and Ser.
    Type: Application
    Filed: February 6, 2001
    Publication date: July 31, 2003
    Applicant: Commonwealth Scientific and Industrial Research Organisation
    Inventors: Robyn Joyce Russell, Richard David Newcomb, Peter Malcolm Campbell, Geoffrey Charles de Quetteville Robin, Charles Claudianos, Kerrie-Ann Smyth, Thomas Mark Boyce, John Graham Oakeshott, Jeremy Colin Brownlie
  • Malathion carboxylesterase
    Patent number: 6235515
    Abstract: The present invention provides an isolated DNA molecule encoding Malathion Carboxylesterase capable of hydrolysing at least one organophosphate selected from the group consisting of carboxylester organophosphates and dimethyloxon organophosphates. The DNA molecule comprises a nucleotide sequence having at least 60%, preferably at least 80% and more preferably at least 95% homology with Lc&agr;E7, in which the protein encoded by the DNA molecule differs from E3 at least in the substitution of Trip at position 251 with an amino acid selected from the group consisting of Leu, Ser, Ala, Ile, Val, Thr, Cys, Met and Gly. The preferred substituents are Leu and Ser.
    Type: Grant
    Filed: May 20, 1998
    Date of Patent: May 22, 2001
    Assignee: The Commonwealth Scientific and Industrial Research Organization
    Inventors: Robyn Joyce Russell, Richard David Newcomb, Peter Malcolm Campbell, Geoffrey Charles de Quetteville Robin, Charles Claudianos, Kerrie-Ann Smyth, Thomas Mark Boyce, John Graham Oakeshott, Jeremy Colin Brownlie
  • Enzyme based bioremediation
    Patent number: 5843758
    Abstract: The present invention provides an E3 esterase from an organophosphate resistant strain of L. cuprina. The invention further provides DNA sequences encoding such E3 esterases and cells transformed with the DNA sequences. In addition, the invention relates to the use of the enzyme and transformed cells as bioremediation agents.
    Type: Grant
    Filed: October 7, 1996
    Date of Patent: December 1, 1998
    Assignee: The Commonwealth of Australia Commonwealth Scientific and Industrial Research Organization
    Inventors: Robyn Joyce Russell, Richard David Newcomb, Geoffrey Charles de Quetteville Robin, Thomas Mark Boyce, Peter Malcolm Campbell, Anthony Gerard Parker, John Graham Oakeshott, Kerrie-Ann Smyth