Abstract: A fetal heart rate electrode assembly, a connector for use therewith and a cable assembly including a housing assembly configured for engagement with the connector. The electrode assembly includes a drive knob configured and located for selective extension of a fetal scalp electrode beyond a distal end thereof. The connector comprises a rotationally omnidirectional contact assembly disposed within a dielectric housing including an annular groove on the exterior thereof The housing assembly includes longitudinally resiliently biased pin contacts for end face contact with the contacts of the connector disposed within an inner housing of the housing assembly having an O-ring and an annular retention element positioned to respectively wipe the exterior of the connector housing and grasp the connector housing at the annular groove when the connector is inserted thereinto. A system and methods of use are also disclosed.

Abstract: The invention provides plant fatty acid amide hydrolase (FAAH) coding sequences. Also provided are constructs comprising these sequences, plants transformed therewith and methods of use thereof. The invention allows the modification of plants for FAAH activity and N-Acylethanolamine levels. Such modification may be used to produce plants that are improved with respect to growth, seed germination, pathogen response and stress tolerance.

Abstract: The invention provides methods for transforming guar plants with Agrobacterium. The invention allows creation of transgenic guar plants with improved traits.

Abstract: Novel compounds of Formula (I) or pharmaceutically acceptable salts, prodrugs and biologically active metabolites thereof of Formula (I) wherein the substituents are as defined herein, which are useful as therapeutic agents.

Abstract: Provided herein are methods of treatment of diastolic heart failure (DHF) by administering an endothelin antagonist, such as sitaxsentan or a pharmaceutically acceptable salt thereof.

Abstract: A lateral file having a cabinet structure which provides improved rigidity against racking, including an improved upright boxlike housing having an improved base associated therewith. The housing has opposed sidewall structures which are defined by identical one-piece monolithic structures each having a generally planar and upright exterior side wall with a pair of channel-like uprights fixed to an inside surface thereof and extending vertically along the exterior side wall adjacent opposite edges thereof. The upright channels and the exterior side wall are formed as a monolithic one-piece structure from a monolithic piece of sheet steel, such as by roll forming. The sidewall structure is generally symmetrical about a vertically extending centerline so that identical sidewall structures can define both the right and left sides of the housing.

Abstract: The present invention is directed to novel imidazopyrazine and imidazopyrimidine compounds of formula (I) wherein the variables are as defined herein. The compounds of formula (I) are useful as kinase inhibitors and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases and proliferative disorders and conditions, for example, cancers.

Abstract: The invention provides methods for decreasing lignin content and improving lignin profiles. Also provided are the plants prepared by the methods of the invention. Such plants may exhibit improved digestibility relative to prior plants.

Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.

Abstract: The invention provides plant binding proteins of N-acylethanolamines. Also provided are constructs comprising coding sequences for the binding proteins, plants transformed therewith and methods of use thereof. The invention allows the modification of plant signaling by N-acylethanolamines. Such modification may be used to produce plants that are improved with respect to growth, seed germination, pathogen response and stress tolerance.

Abstract: The invention relates generally to combination therapies comprising an endothelin A receptor (ETA) antagonist and a phosphodiesterase 5 (PDE5) inhibitor, pharmaceutical compositions comprising ETA antagonist and PDE5 inhibitor and methods of treating various disorders comprising administering an ETA antagonist and a PDE5 inhibitor. In particular, the combination therapies and pharmaceutical compositions are useful for the treatment and/or prevention of cardiac disorders such as pulmonary arterial hypertension (PAH).

Abstract: The invention provides method and compositions for the modulation of condensed tannin production in plants. The methods of the invention allow creation of plants having novel phenotypes. Increased expression of condensed tannins in plants may be used to increase the nutritional value of food plants for both human and animal consumption. Increased condensed tannin content also reduces the potential for bloat in animals fed certain forage plants low in condensed tannin content. The invention may also be used to modify plant pigmentation.

Abstract: A cargo box for a vehicle having a support bar to which are attached a first side hollow tube and a second side hollow tube. On the bottom of a box are connected a first hollow tube and a second hollow tube. A first rod releasably connects the first side hollow tube and the first hollow tube while a second rod releasably connects the second side hollow tube and the second hollow tube. In a first option, a middle hollow tube accommodates a hitch so that a vehicle can be towed behind the vehicle, preferably a recreational vehicle, to which the support bar is attached. Another option, elevates the box.

Abstract: Soybean and Medicago truncatula CYP93C genes have been isolated which encode a cytochrome P450 that can catalyze the aryl migration of a flavanone to yield an isoflavanone intermediate or an isoflavone. Plants can now be genetically engineered to produce isoflavones that provide potential human health benefits and increase disease resistance in plants. Isoflavones can now be produced in transgenic plants species in which isoflavones do not naturally occur, i.e., in species other than legumes. Alternatively, introducing infection-inducible isoflavonoid biosynthesis into non-legumes qualitatively complements these plants phytoalexin defenses against microbial pathogens, whereas over-expression of the isoflavonoid pathway in legumes quantitatively increases this defense response. Finally, modifying the extend of production of isoflavonoids in legume roots positively impacts nodulation efficiency and therefore plant yield.

Abstract: A software routine, method of use of such software routine, and associated business method for the distribution of piracy-resistant audio recordings via digital recording media.

Abstract: Compounds of the present invention are useful for inhibiting protein tyrosine kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

Abstract: The current invention provides plant promoter sequences. Compositions comprising these promoter sequence are described, as are plants transformed with such compositions. Further provided are methods for the expression of transgenes in plants comprising the use of these sequences. The methods of the invention include the direct creation of transgenic plants with the promoters by genetic transformation, as well as by plant breeding methods. The sequences of the invention represent valuable new tools for the creation of transgenic plants, preferably having one or more added beneficial characteristics.

Abstract: Prosthetic joints, components for prosthetic joints, superhard bearing and articulation surfaces, diamond bearing and articulation surfaces, substrate surface topographical features, materials for making joints, bearing and articulation surfaces, and methods for manufacturing and finishing the same, and related information are disclosed, including prosthetic knee joint having at least one diamond articulation surface.

Abstract: Various nozzles, components of nozzles, and methods, materials and devices for making them are disclosed.

Abstract: The invention provides plant isoflavonoid hydroxylase coding sequences. Also provided are constructs comprising these sequences, plants transformed therewith and methods of use thereof. In certain aspects of the invention, plants transformed with the nucleic acids are provided exhibiting improved pest and disease resistance. Plants provided by the invention may also exhibit improved nutritional qualities.