Abstract: This invention is in the area of improved anti-aP2 antibodies and antigen binding agents, and compositions thereof, which target the lipid chaperone aP2/FABP4 (referred to as “aP2”) for use in treating disorders such as diabetes, obesity, cardiovascular disease, fatty liver disease, and/or cancer, among others. In one aspect, improved treatments for aP2 mediated disorders are disclosed in which serum aP2 is targeted and the biological activity of aP2 is neutralized or modulated using low-binding affinity aP2 monoclonal antibodies, providing lower fasting blood glucose levels, improved systemic glucose metabolism, increased systemic insulin sensitivity, reduced fat mass, reduced liver steatosis, reduced cardiovascular disease and/or a reduced risk of developing cardiovascular disease.

Abstract: The present invention provides a method for monitoring adherence by a patient to a medication. The method comprises the steps of obtaining timing data in respect of each dose of a medication taken by a patient over a time interval, estimating the concentration of the medication in the patient's body over the time interval based on the dose timing data; determining the proportion of time over the time interval the concentration of the medication in the patient's body exceeds a target concentration; and calculating an adherence score for the patient based on the determined proportion of time the concentration of the medication in the patient's body exceeds the target concentration.

Abstract: Tumor treating fields (TTFields) may be applied to a person's body using six different types of electrodes. More specifically, the electrodes may be shaped and dimensioned (a) for insertion into blood vessels so that they make contact with the person's blood; (b) for insertion into a central canal of a spinal cord, so that they make contact with the CSF; (c) for insertion into a body orifice at a position that contacts an interior surface of the person's body; (d) for affixation to skin of the person's body (e.g., on the person's head, torso, back, abdomen, etc.); (e) for insertion into a brain ventricle so that they make contact with the person's CSF; or (f) for insertion into lymph vessels so that they make contact with the person's lymph. Applying an AC voltage between any two of these electrodes will create TTFields in respective parts of the person's body.

Abstract: The present disclosure provides methods and systems for reducing interference by one or more bubbles in a sensing assembly. Bubble prevention arrangements can use surfaces located in a fluid channel to provide surfaces with higher affinity for bubbles relative to the other surfaces so that the surface retains one or more bubbles within a bubble collection region; and/or to divert at least a portion of any bubbles passing through an opening in the fluid channel. Additionally or alternatively, bubble prevention arrangements comprise an agitation device configured to agitate liquid within the fluid channel. Additionally or alternatively, bubble prevention arrangements are configured to displace one or more bubbles in a region on or adjacent the sensing surface so as to reduce interference of one or more bubbles on the sensing surface.

Abstract: The present disclosure provides methods and systems for reducing interference by one or more bubbles in a sensing assembly by determining a first property of the solution and using the first property in a removal step.

Abstract: Systems and methods for reference electrodes are disclosed. In one aspect, a measurement system includes a pseudo-reference electrode configured to provide a reference potential and a dependence electrode configured to generate a dependence potential when exposed to a sample. Both the reference potential and the dependence potential vary based on a property of the sample. An electrochemical sensor includes the pseudo-reference electrode and the dependence electrode.

Abstract: A sensor assembly for determining a property of an analyte in a sample, where a modification unit comprising a set of modification electrodes with at least a first modification electrode is provided adjacent or on a sensing element, which includes a capture species, and which modification unit is configured modify a property of at least a portion of a sample received on the sensing element.

Abstract: A device configuration method for a vehicle in a fleet of vehicles comprises, at a computing device communicatively coupled to electronic devices provided in the vehicle, obtaining at least one template configuration file assigned to the computing device based on a user selection, the at least one template configuration file specific to the fleet of vehicles and comprising first configuration data indicative of a manner in which the computing device is to interface with the electronic devices, and second configuration data indicative of a desired setting for at least one configuration parameter of one or more electronic devices, automatically self-configuring for operation based on the first configuration data, and transmitting, at least in part, the second configuration data to the one or more electronic devices to cause the one or more electronic devices to adjust the at least one configuration parameter to the desired setting.

Abstract: A reference electrode of an electrochemical sensor includes a substrate having well, a channel, and a conductive element therein. The well extends from a first surface of a substrate towards a second surface of the substrate. The channel is within the substrate. A longitudinal axis of the channel may be substantially perpendicular to a longitudinal axis of the well. The channel has a first end connected to the well and the conductive element is exposed to a second of the channel. The channel and the wells form a flow path of a conductive medium. A valve is coupled to the flow path and configured to control a flow of the conductive medium to the electrically conductive element through the flow path.

Abstract: A reference electrode of an electrochemical sensor includes a substrate having internal walls defining a well and a channel. The reference electrode includes a conductive element disposed in the substrate. The well extends from a first surface of a substrate towards a second surface of the substrate. The channel is within the substrate. The channel has a first end connected to the well and a second end that is in contact with the conductive element. The reference electrode may include an additional well that extends from the first surface towards the second surface. The additional well may be connected to the second end of the channel and may be in contact with the conductive element. The channel and the wells form a flow path of a conductive medium. The flow path may be coupled to an agitating element or heating element that promotes flow of the conductive medium.

Abstract: A reference electrode of an electrochemical sensor includes a substrate having a well, a channel, and a conductive element. The well extends from a first surface of a substrate towards a second surface of the substrate. The channel is within the substrate. A longitudinal axis of the channel may be substantially perpendicular to a longitudinal axis of the well. The channel has a first end connected to the well and a second end that is in contact with the conductive element. The channel and the wells form a flow path of a conductive medium. The flow path may be coupled to a manipulating element such as an agitating element or heating element that promotes flow of the membrane.

Abstract: A system and method includes presenting a single product to be located in the retail store to the customer using a mobile application running on the mobile device, receiving an indication from the customer either to dismiss the product or to add the product to a grocery basket of the mobile application to form user data, presenting a cue card to ask the customer a question, receiving an answer from the customer as to yes or no to the question to form cue card data, using a data model and an algorithm to predict the most probable product the customer is going to want to add to the grocery basket, transmitting a representation of the most probable product, and displaying the most probable product on a graphical display of the mobile device, wherein the most probable product is based on the user data and the cue card data.

Abstract: Methods and systems for commercial, sustainable and scalable indoor & outdoor farming can use aquaponics integrated with apiculture and breeding of Lepidoptera for pollination, renewable energy and heating sources, hybrid aquaculture and growing beds, vertical growing towers, specialized shipping container modules, and an optimal farm planning tool that can be placed in any environment and climate, in rural or urban areas and begin producing food and other crops within a few weeks.

Abstract: A system and method includes presenting a single product to be located in the retail store to the customer using a mobile application running on the mobile device, receiving an indication from the customer either to dismiss the product or to add the product to a grocery basket of the mobile application to form user data, presenting a cue card to ask the customer a question, receiving an answer from the customer as to yes or no to the question to form cue card data, using a data model and an algorithm to predict the most probable product the customer is going to want to add to the grocery basket, transmitting a representation of the most probable product, and displaying the most probable product on a graphical display of the mobile device, wherein the most probable product is based on the user data and the cue card data.

Abstract: An apparatus for carrying and/or storing shelves which is capable of folding into a compact condition to minimize the footprint of the device when not in use for carrying or storing shelves. The apparatus includes a releasable transverse cross member extending between the side frames to form a base for supporting shelves.

Abstract: A system and method of identity verification is disclosed. The system has a processor and an identity confirmation function. The identity confirmation function executable by the processor to provide a caller identity confirmation if a result indicates an obtained fingerprint data, from a fingerprint scan on the caller electronic device occurring during the audio call resulting from the fingerprint scan request, matches a stored fingerprint data associated with the caller.

Abstract: An apparatus for carrying and/or storing shelves which is capable of folding into a compact condition to minimize the footprint of the device when not in use for carrying or storing shelves. The apparatus includes a releasable transverse cross member extending between the side frames to form a base for supporting shelves.

Abstract: The present description discusses apparatuses and methods for applying straps around a bundle of objects by applying a variable force to tension the strap around the bundle of objects and then actuating a series of cams to control the sealing of the strap around the bundle of objects. The apparatus includes a track assembly extending substantially about a strapping station. The track assembly is adapted to receive a strap and to release the strap during a tensioning operation. An accumulator delivers strap to the track assembly. The accumulator has a strap conveyor system that defines a strap path and an accumulator container adjacent to the strap path. Strap can be accumulated in the accumulator container and subsequently delivered to the track assembly.

Abstract: An apparatus for carrying and/or storing shelves which is capable of folding into a compact condition to minimize the footprint of the device when not in use for carrying or storing shelves. The apparatus includes a releasable transverse cross member extending between the side frames to form a base for supporting shelves.

Abstract: An apparatus for carrying and/or storing shelves which is capable of folding into a compact condition to minimize the footprint of the device when not in use for carrying or storing shelves. The apparatus includes a releasable transverse cross member extending between the side frames to form a base for supporting shelves.