Patents by Inventor Richard Durley

Richard Durley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

(R)-Chiral Halogenated Substituted Fused Heterocyclic Amino Compounds Useful for Inhibiting Cholesterol Ester Transfer Protein Activity

Publication number: 20070219274

Abstract: The invention relates to substituted aryl and heteroaryl (R)-Chiral Halogenated 1-Substitutedamino-(n+1)-Alkanol compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other coronary artery diseases. Novel high yield, stereoselective processes for the preparation of the chiral substituted alkanol compounds from chiral and achiral intermediates are described.

Type: Application

Filed: March 29, 2007

Publication date: September 20, 2007

Inventors: James Sikorski, Richard Durley, Margaret Grapperhaus, Mark Massa, Emily Reinhard, Yvette Fobian, Michael Tollefson, Lijuan Wang, Brian Hickory, Monica Norton, William Vernier, Deborah Mischke, Michelle Promo, Ashton Hamme, Dale Spangler, Melvin Rueppel
SUBSTITUTED PYRIMIDINONES

Publication number: 20070167621

Abstract: Disclosed are compounds Formula I and pharmaceutically acceptable salts thereof, wherein R1, R2, R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.

Type: Application

Filed: July 14, 2006

Publication date: July 19, 2007

Applicant: PHARMACIA CORPORATION

Inventor: Richard Durley
Diaryl Substituted Pyridinones

Publication number: 20070088033

Abstract: Disclosed are compounds Formula I and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.

Type: Application

Filed: September 13, 2006

Publication date: April 19, 2007

Inventors: Balekudru Devadas, John Walker, Shaun Selness, Terri Boehm, Richard Durley, Rajesh Devraj, Brian Hickory, Paul Rucker, Kevin Jerome, Heather Madsen, Edgardo Alvira, Michele Promo, Radhika Blevis-Bal, Laura Marruto, Jeff Hitchcock, Thomas Owen, Win Naing, Li Xing, Huey Shieh, Aruna Sambandam, Shuang Liu, Ian Scott, Kevin McGee
(R)-chiral halogenated substituted fused heterocyclic amino compounds useful for inhibiting cholesterol ester transfer protein activity

Publication number: 20060229304

Abstract: The invention relates to substituted aryl and heteroaryl (R)-Chiral Halogenated 1-Substitutedamino-(n+1)-Alkanol compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other coronary artery diseases. Novel high yield, stereoselective processes for the preparation of the chiral substituted alkanol compounds from chiral and achiral intermediates are described.

Type: Application

Filed: March 9, 2006

Publication date: October 12, 2006

Inventors: James Sikorski, Richard Durley, Margaret Grapperhaus, Mark Massa, Emily Reinhard, Yvette Fobian, Michael Tollefson, Lijuan Wang, Brian Hickory, Monica Norton, William Vernier, Deborah Mischke, Michele Promo, Ashton Hamme, Dale Spangler, Melvin Rueppel
Diaryl substituted pyridinones

Publication number: 20060211694

Abstract: Disclosed are compounds Formula I and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.

Type: Application

Filed: September 14, 2005

Publication date: September 21, 2006

Applicant: Pharmacia Corporation, Global Patent Department

Inventors: Balekudru Devadas, John Walker, Shaun Selness, Terri Boehm, Richard Durley, Rajesh Devraj, Brian Hickory, Paul Rucker, Kevin Jerome, Heather Madsen, Edgardo Alvira, Michele Promo, Radhika Blevis-Bal, Laura Marruto, Jeff Hitchcock, Thomas Owen, Win Naing, Li Xing, Huey Shieh, Aruna Sambandam, Shuang Liu, Ian Scott, Kevin McGee
2-Amino-2-alkyl-4 hexenoic and hexynoic acid derivatives useful as nitric oxide synthase inhibitors

Publication number: 20050256199

Abstract: The present invention relates to 2-amino-2-alkyl-4 hexenoic and hexynoic acid derivatives and their use in therapy, in particular their use as nitric oxide synthase inhibitors.

Type: Application

Filed: July 21, 2005

Publication date: November 17, 2005

Inventors: Richard Durley, James Sikorski, Donald Hansen, Michelle Promo, Ronald Webber, Alok Awasthi, Alan Moormann
Substituted pyridinones

Publication number: 20050176775

Abstract: Disclosed are compounds of Formula I and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.

Type: Application

Filed: August 13, 2004

Publication date: August 11, 2005

Inventors: Balekudru Devadas, John Walker, Shaun Selness, Terri Boehm, Richard Durley, Rajesh Devraj, Brian Hickory, Paul Rucker, Kevin Jerome, Heather Madsen, Edgardo Alvira, Michele Promo, Radhika Blevis-Bal, Laura Marrufo, Jeff Hitchcock, Thomas Owen, Win Naing, Li Xing, Huey Shieh, Aruna Sambandam, Shuang Liu, Ian Scott, Kevin McGee
Amidino compounds useful as nitric oxide synthase inhibitors

Publication number: 20050165106

Abstract: The present invention relates to amidino compounds and salts and prodrugs thereof. In another embodiment the present invention also provides a use of the present compounds in therapy, particular as nitric oxide synthase inhibitors. In a further embodiment, the present invention provides methods of making the amidino compounds.

Type: Application

Filed: January 10, 2005

Publication date: July 28, 2005

Applicant: Pharmacia Corporation

Inventors: Ronald Webber, Richard Durley, Alok Awasthi, Arijia Bergmanis, Kam Fok, Scott Ganser, Timothy Hagen, E. Hallinan, Donald Hansen, Brian Hickory, Pamela Manning, Michael Mao, Alan Moormann, Barnett Pitzele, Michelle Promo, Richard Schartman, Jeffrey Scholten, Jeffrey Snyder, Mihaly Toth, Mahima Trivedi, Sofya Tsymbalov, Foe Tjoeng
(R)-chiral halogenated substituted fused heterocyclic amino compounds useful for inhibiting cholesterol ester transfer protein activity

Publication number: 20050043294

Abstract: The invention relates to substituted aryl and heteroaryl (R)-Chiral Halogenated 1-Substitutedamino-(n+1)-Alkanol compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other coronary artery diseases. Novel high yield, stereoselective processes for the preparation of the chiral substituted alkanol compounds from chiral and achiral intermediates are described.

Type: Application

Filed: August 27, 2004

Publication date: February 24, 2005

Inventors: James Sikorski, Richard Durley, Margaret Grapperhaus, Mark Massa, Emily Reinhard, Yvette Fobian, Michael Tollefson, Lijuan Wang, Brian Hickory, Monica Norton, William Vernier, Deborah Mischke, Michele Promo, Ashton Hamme, Dale Spangler, Melvin Rueppel