Abstract: Devices and methods for measuring a concentration of a target analyte in a biological fluid in vivo are provided herein. In some examples, a device includes an indwelling sensor and sensor electronics. The sensor may include a substrate; a first electrode disposed on the substrate; an ionophore disposed on the substrate to selectively transport the target ion to or within the first electrode; and a second electrode disposed on the substrate. The sensor electronics is configured to generate a signal corresponding to an electromotive force which is at least partially based on a potential difference that is generated between the first electrode and the second electrode responsive to the ionophore transporting the target ion to the first electrode.

Abstract: An interactive vacation destination selection system operates through a back and front ends. The back end identifies criteria which may be important to a consumer, and categorizes and assigns images to the criteria. The front end to the system assesses what a consumer wants in a vacation destination, identifies vacation destinations having the attributes that satisfy those wants, and then displays comparative data on those vacation destinations. By providing to the system basic information on the consumer and his or her travel companions, general information on how far the consumer is willing to travel, preferred weather conditions, a budget range, and the consumer's selection of criteria from one or more categories, the system is capable of determining a suitable vacation destination and accommodation for the consumer and the travel companions, even without being provided information on to where the consumer wants to travel.