Patents by Inventor Richard E. Herman

Richard E. Herman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20150050245
    Abstract: This invention relates to controlled release formulations of probiotic bacteria and bacteriophages, including combined formulations of probiotic bacteria and bacteriophages. The formulations contain a hydrophilic agent, an electrolytic agent and a polysaccharide and may be in tablet form for oral delivery to the intestinal system. In one preferred aspect, the formulations of the present invention effect the simultaneous introduction or addition of probiotic bacteria and bacteriophages to cause the subtraction or removal of undesirable bacteria.
    Type: Application
    Filed: August 14, 2014
    Publication date: February 19, 2015
    Inventors: Richard E. Herman, Timothy Gamble
  • Patent number: 8063178
    Abstract: Trp cage binding domains polypeptides are disclosed. The Trp cage binding domains have the generic formulae of SEQ ID NO: 2, 7, 10 or 11. They can be efficiently produced and screened using phage display technology.
    Type: Grant
    Filed: December 12, 2007
    Date of Patent: November 22, 2011
    Assignee: Marina Biotech, Inc.
    Inventors: Steven C. Quay, Douglas L. Badders, Richard E. Herman, Michael E. Houston, Jr., Paul Hickok Johnson
  • Patent number: 7772189
    Abstract: This disclosure provides the construction, expression, and selection of the mutated genes that encode novel Trp cage polypeptides with desirable binding properties, as well as the novel Trp cage polypeptides themselves. The substances or targets bound by these novel Trp cage polypeptides may be but need not be proteins or polypeptides. Targets may include other biological or synthetic macromolecules as well as other organic and inorganic substances. Further, targets may also include a single or multiple cell or tissue types. The present invention achieves genetic variants of Trp cage-encoding nucleic acids through controlled random mutagenesis of the nucleic acids yielding a mixture of Trp cage polypeptides that are capable of binding targets.
    Type: Grant
    Filed: February 5, 2010
    Date of Patent: August 10, 2010
    Assignee: MDRNA, Inc.
    Inventors: Richard E. Herman, Ekaterina G. Makienko, Douglas L. Badders, Mark Fuller
  • Publication number: 20100137225
    Abstract: This disclosure provides the construction, expression, and selection of the mutated genes that encode novel Trp cage polypeptides with desirable binding properties, as well as the novel Trp cage polypeptides themselves. The substances or targets bound by these novel Trp cage polypeptides may be but need not be proteins or polypeptides. Targets may include other biological or synthetic macromolecules as well as other organic and inorganic substances. Further, targets may also include a single or multiple cell or tissue types. The present invention achieves genetic variants of Trp cage-encoding nucleic acids through controlled random mutagenesis of the nucleic acids yielding a mixture of Trp cage polypeptides that are capable of binding targets.
    Type: Application
    Filed: February 5, 2010
    Publication date: June 3, 2010
    Applicant: MDRNA, INC.
    Inventors: Richard E. Herman, Ekaterina G. Makienko, Douglas L. Badders, Mark Fuller
  • Patent number: 7704953
    Abstract: The present disclosure relates to the construction, expression, and selection of genes that encode novel Trp cage polypeptides with desirable cell and/or tissue binding properties, as well as the novel Trp cage polypeptides themselves. A polypeptide of this disclosure may contain all or part of amino acid sequence AAADX1YX2QWLX3X4X5GPX6SGRPPPX7 (SEQ ID NO: 4), wherein Xn represents an amino acid found in position n, the polypeptide comprising a tryptophan cage (Trp cage).
    Type: Grant
    Filed: January 26, 2007
    Date of Patent: April 27, 2010
    Assignee: MDRNA, Inc.
    Inventors: Richard E. Herman, Ekaterina G. Makienko, Douglas L. Badders, Mark Fuller
  • Patent number: 7329725
    Abstract: Trp cage binding domain polypeptides are disclosed. The Trp cage binding domains have the generic formulas of SEQ ID NO: 2, 7, 10 or 11. They can be efficiently produced and screened using phage display technology.
    Type: Grant
    Filed: October 29, 2004
    Date of Patent: February 12, 2008
    Assignee: Nastech Pharmaceutical Company Inc.
    Inventors: Steven C. Quay, Douglas L. Badders, Richard E. Herman, Michael E. Houston, Jr., Paul Hickok Johnson
  • Publication number: 20070197444
    Abstract: A tryptophan cage binding domain polypeptide containing of all or part of amino acid sequence AAADX1YX2QWLX3X4X5GPX6SGRPPPX7 (SEQ ID NO: 4), wherein Xn represents an amino acid found in position n, the polypeptide comprising a tryptophan cage (Trp cage). A cell binding domain polypeptide having an amino acid sequence produced by phage display.
    Type: Application
    Filed: January 26, 2007
    Publication date: August 23, 2007
    Inventors: Richard E. Herman, Ekaterina G. Makienko, Douglas L. Badders, Mark Fuller
  • Patent number: 5256425
    Abstract: New strains of L. acidophilus capable of adhering to the tissue cells of various species of animals and having resistance to both erythromycin and streptomycin are described. The strains may be used in a suitable carrier as a dietary supplement for providing a source of the bacteria in an animal.
    Type: Grant
    Filed: September 29, 1992
    Date of Patent: October 26, 1993
    Assignee: Bio Techniques Laboratories, Inc.
    Inventors: Richard E. Herman, Douglas R. Ware, Julia E. Clarke
  • Patent number: 5179020
    Abstract: New strains of L. acidophilus capable of adhering to the tissue cells of various species of animals and having resistance to both erythromycin and streptomycin are described. The strains may be used in a suitable carrier as a dietary supplement for providing a source of the bacteria in an animal.
    Type: Grant
    Filed: August 19, 1991
    Date of Patent: January 12, 1993
    Assignee: Bio Techniques Laboratories, Inc.
    Inventors: Richard E. Herman, Douglas R. Ware, Julia E. Clarke
  • Patent number: 5139792
    Abstract: A method for preparing, at an animal feedlot, a suspension of microaerophilic or anaerobic bacteria at a known, accurate concentration in anticipation of dispensing the suspension of bacteria into animal feed or drinking water. The method allows the livestock feedlot or poultry operators to maintain the suspension of bacteria in a substantially viable condition without significant loss of viability and without requiring constant or intermittent agitation after the suspension is created. Refrigeration of the suspension is also unnecessary if the suspension of bacteria is dispensed within a predetermined period of time after preparation.
    Type: Grant
    Filed: July 19, 1990
    Date of Patent: August 18, 1992
    Assignee: Bio-Techniques Laboratories, Inc.
    Inventors: Douglas R. Ware, Richard E. Herman, Leslie A. Walter
  • Patent number: 4091413
    Abstract: A system for securing a pay-TV channel by coherently moving the RF components of the channel (with or without an encoding signal) beyond the AFC holding range of commercially available tuners. The system is comprised of means for mixing the channel carrier with a signal that is varied beyond that AFC holding range at a low rate between approximately 0.75 Hz and 1000 Hz. For greater security, an amplitude-modulated encoding signal is injected at an IF frequency that is between the audio subcarrier and the video subcarrier. The encoding signal is preferably a multiple of the line scanning frequency in order to interfere with both video and audio components. For decoding, a converter with adequate AFC holding range at the receiver of a subscriber is coupled to the receiver by a sharply tuned filter which traps the injected encoding signal.
    Type: Grant
    Filed: January 17, 1977
    Date of Patent: May 23, 1978
    Inventor: Richard E. Herman