Patents by Inventor Richard E. Holmes

Richard E. Holmes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5744597
    Abstract: A stereoselective anion glycosylation process for preparing beta- and alpha-anomer enriched 2', 2'-difluoro-2'-deoxynucleosides and 2'-deoxy-2'-fluoronucleosides by reacting an alpha- or beta-anomer enriched 2-deoxy-2-fluorocarbohydrate or 2-deoxy-2,2-difluorocarbohydrate with at least a molar equivalent of a salt of a nucleobase derivative in an inert solvent.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: April 28, 1998
    Assignee: Eli Lilly and Company
    Inventors: Ta-Sen Chou, Cora S. Grossman, Larry Wayne Hertel, Richard E. Holmes, Charles D. Jones, Thomas E. Mabry
  • Patent number: 5011938
    Abstract: 7-Substituted bicyclic pyrazolidinone compounds as antimicrobials and the corresponding intermediates, are discussed or provided. The use of the antimicrobial compounds in pharmaceutical compositions and in methods for treating bacterial infections is set forth.
    Type: Grant
    Filed: April 3, 1990
    Date of Patent: April 30, 1991
    Assignee: Eli Lilly and Company
    Inventors: Charles J. Barnett, Richard E. Holmes, Louis N. Jungheim, Sandra K. Sigmund, Robert J. Ternansky
  • Patent number: 4940718
    Abstract: 7-Substituted bicyclic pyrazolidinone compounds as antimicrobials and the corresponding intermediates, are discussed or provided. The use of the antimicrobial compounds in pharmaceutical compositions and in methods for treating bacterial infections is set forth.
    Type: Grant
    Filed: October 2, 1989
    Date of Patent: July 10, 1990
    Assignee: Eli Lilly and Company
    Inventors: Charles J. Barnett, Richard E. Holmes, Louis N. Jungheim, Sandra K. Sigmund, Robert J. Ternansky
  • Patent number: 4826993
    Abstract: 4-Substituted 1-(optionally substituted)diazolidinones are intermediates to 7-substituted bicyclic pyrazolidinone antimicrobials.
    Type: Grant
    Filed: May 14, 1986
    Date of Patent: May 2, 1989
    Assignee: Eli Lilly and Company
    Inventors: Richard E. Holmes, Louis N. Jungheim
  • Patent number: 4803464
    Abstract: A high resolution raster display includes a central processor for providing image data, a digital image processing circuit for converting the image data to display signals, and an analog display circuit for converting the display signals to drive signals for driving a CRT to form a color raster display on the screen of the CRT. The digital image processing circuit includes a display memory for storing the image data and a programmable attribute look-up table for storing attribute data. Under the control of the central processor, the image data stored in the display memory is read out and is used to address the attribute look-up table which provides attribute signals as an output. A pixel rate converter reads in the attribute signals at a first rate and outputs analog display signals at a second rate which is much higher than the first rate, with a video bandwidth of up to 210 MHz.
    Type: Grant
    Filed: February 9, 1988
    Date of Patent: February 7, 1989
    Assignee: Gould Inc.
    Inventors: Richard E. Holmes, Joe A. Mays
  • Patent number: 4767871
    Abstract: 4-(Protected amino)-3-oxo-1-(substituted and unsubstituted methylene)-1,2-pyrazolidinium ylides are intermediates to 7-substituted bicyclic pyrazolidione antimicrobials.
    Type: Grant
    Filed: April 30, 1987
    Date of Patent: August 30, 1988
    Assignee: Eli Lilly and Company
    Inventors: Richard E. Holmes, Louis N. Jungheim
  • Patent number: 4734505
    Abstract: 1-(Alkylated)-2-(acylated)diazolidinones are intermediates to bicyclic pyrazolidinone antimicrobial compounds. The instant compounds have the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are as defined in the specification.
    Type: Grant
    Filed: May 14, 1986
    Date of Patent: March 29, 1988
    Assignee: Eli Lilly and Company
    Inventor: Richard E. Holmes
  • Patent number: 4734504
    Abstract: 1-Alkylated diazolidinones are intermediates to bicyclic pyrazolidinone antimicrobial compounds. The instant compounds have the formula ##STR1## wherein R.sub.1, R.sub.2, and R.sub.3, have the meanings as defined in the specification.
    Type: Grant
    Filed: May 14, 1986
    Date of Patent: March 29, 1988
    Assignee: Eli Lilly and Company
    Inventor: Richard E. Holmes
  • Patent number: 4687973
    Abstract: In a cathode ray tube display system, correction factors for X and Y position, astigmatism, focus and shading are recorded for preselected locations in digital memory circuits. Those correction factors bordering the actual beam position are selected and are converted to analog form. The correction factors applied to the system are determined by analogue interpolation, that is, the correction factors are combined in proportion to the proximity of the beam relative to those preselected locations where the correction factors were recorded. Use is made of resistance ladders and multiplexers in the interpolation circuits.
    Type: Grant
    Filed: July 9, 1986
    Date of Patent: August 18, 1987
    Assignee: Electronic Image Systems, Inc.
    Inventors: Richard E. Holmes, Joe A. Mays, Michael C. Tyler
  • Patent number: 4133884
    Abstract: Substituted pyrroloquinoxalinones and diones, useful as anti-inflammatory and anti-thrombotic agents.
    Type: Grant
    Filed: December 12, 1977
    Date of Patent: January 9, 1979
    Assignee: Eli Lilly and Company
    Inventor: Richard E. Holmes
  • Patent number: 4110465
    Abstract: 7-Amino and 7-alkanoylamino-2-oxo-3-phenylindolines, useful as anti-inflammatory and anti-thrombotic agents.
    Type: Grant
    Filed: November 25, 1977
    Date of Patent: August 29, 1978
    Assignee: Eli Lilly and Company
    Inventor: Richard E. Holmes
  • Patent number: 4087527
    Abstract: Substituted pyrroloquinoxalinones and diones, useful as anti-inflammatory and anti-thrombotic agents.
    Type: Grant
    Filed: September 26, 1977
    Date of Patent: May 2, 1978
    Assignee: Eli Lilly and Company
    Inventor: Richard E. Holmes
  • Patent number: 4075206
    Abstract: Substituted pyrroloquinoxalinones and diones, useful as anti-inflammatory and anti-thrombotic agents.
    Type: Grant
    Filed: February 25, 1977
    Date of Patent: February 21, 1978
    Assignee: Eli Lilly and Company
    Inventor: Richard E. Holmes
  • Patent number: 4006161
    Abstract: Thio-substituted 2-oxoindolines have the formula ##SPC1##In which one of R or R.sub.1 is hydrogen and the other is R.sub.2 --S--, in which R.sub.2 is C.sub.1 -C.sub.3 alkyl, benzyl, halobenzyl, nitrobenzyl, C.sub.1 -C.sub.3 alkylbenzyl, or phenyl. These compounds are active in relieving a condition associated with anxiety, tension, or like emotional disturbances.
    Type: Grant
    Filed: December 26, 1973
    Date of Patent: February 1, 1977
    Assignee: Eli Lilly and Company
    Inventors: Richard E. Holmes, Glen P. Jourdan
  • Patent number: RE30314
    Abstract: Substituted pyrroloquinoxalinones and diones, useful as anti-inflammatory and anti-thrombotic agents.
    Type: Grant
    Filed: April 26, 1979
    Date of Patent: June 24, 1980
    Assignee: Eli Lilly and Company
    Inventor: Richard E. Holmes
  • Patent number: RE30415
    Abstract: Substituted pyrroloquinoxalinones and diones, useful as anti-inflammatory and anti-thrombotic agents.
    Type: Grant
    Filed: May 29, 1979
    Date of Patent: October 7, 1980
    Assignee: Eli Lilly and Company
    Inventor: Richard E. Holmes