Patents by Inventor Richard E. Middleton

Richard E. Middleton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • High throughput screening by measurement of intracellular calcium levels
    Patent number: 6514709
    Abstract: The present invention provides assays in which intracellular chelators are used to alter the kinetics of signal generation triggered by divalent cations, particularly calcium influx into the cell. The use of an intracellular chelator in the assay can delay and prolong the signal, allowing the signal to be detected by automated instrumentation without the need for simultaneous liquid handling at the time of detection.
    Type: Grant
    Filed: March 13, 2001
    Date of Patent: February 4, 2003
    Assignee: Merck & Co., Inc.
    Inventors: Stephan K. Grant, Gregory J. Kaczorowski, Richard E. Middleton