Patents by Inventor Richard E. Rothman

Richard E. Rothman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Molecular diagnosis of bacteremia
    Patent number: 8288524
    Abstract: A highly specific assay can be used for the detection of bacteremia in the clinical setting. The ubiquitous background endogenous DNA present in all PCR reagents is eliminated using a restriction endonuclease digestion. Universal primers for eubacteria are used for detection, and specific primers or probes for bacterial species can be used for identification of species.
    Type: Grant
    Filed: August 3, 2010
    Date of Patent: October 16, 2012
    Assignee: The Johns Hopkins University
    Inventors: Richard E. Rothman, Maulik D. Majmudar, Charlotte A. Gaydos
  • Molecular Diagnosis of Bacteremia
    Publication number: 20110008791
    Abstract: A highly specific assay can be used for the detection of bacteremia in the clinical setting. The ubiquitous background endogenous DNA present in all PCR reagents is eliminated using a restriction endonuclease digestion. Universal primers for eubacteria are used for detection, and specific primers or probes for bacterial species can be used for identification of species.
    Type: Application
    Filed: August 3, 2010
    Publication date: January 13, 2011
    Applicant: JOHNS HOPKINS UNIVERSITY
    Inventors: Richard E. Rothman, Maulik D. Majmudar
  • Quantitative Assay for the Simultaneous Detection and Speciation of Bacterial Infections
    Publication number: 20100203518
    Abstract: An adaptation of the real-time PCR assay allows for highly sensitive detection of any eubacterial species with simultaneous speciation. The assay relies on a ‘multiprobe’ design in which a single set of highly conserved sequences encoded by the 16S rRNA gene serves as the primer pair, and it is used in combination with both an internal highly conserved sequence, the universal probe, and an internal variable region, the species-specific probe. A pre-PCR ultrafiltration step can be used to effectively decontaminate or remove background DNA. The real-time system reliably identifies 14 common bacterial species with a detection limit of 50 fg.
    Type: Application
    Filed: September 11, 2009
    Publication date: August 12, 2010
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: RICHARD E. ROTHMAN, SAMUEL YANG, SHIN LIN, GABOR D. KELEN, CHARLOTTE A. GAYDOS
  • Molecular Diagnosis of Bacteremia
    Publication number: 20090215059
    Abstract: A highly specific assay can be used for the detection of bacteremia in the clinical setting. The ubiquitous background endogenous DNA present in all PCR reagents is eliminated using a restriction endonuclease digestion. Universal primers for eubacteria are used for detection, and specific primers or probes for bacterial species can be used for identification of species.
    Type: Application
    Filed: January 5, 2009
    Publication date: August 27, 2009
    Applicant: Johns Hopkins University
    Inventors: Richard E. Rothman, Maulik D. Majmudar
  • Molecular diagnosis of bactermia
    Publication number: 20040005555
    Abstract: A highly specific assay can be used for the detection of bacteremia in the clinical setting. The ubiquitous background endogenous DNA present in all PCR reagents is eliminated using a restriction endonuclease digestion. Universal primers for eubacteria are used for detection, and specific primers or probes for bacterial species can be used for identification of species.
    Type: Application
    Filed: August 29, 2001
    Publication date: January 8, 2004
    Inventors: Richard E. Rothman, Maulik D. Majmudar