Patents by Inventor Richard E. Walters
Richard E. Walters has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11578318Abstract: An object of the invention is to provide an electroporation method for treating vesicles with exogenous material for insertion of the exogenous material into the vesicles which includes the steps of: a. retaining a suspension of the vesicles and the exogenous material in a treatment volume in a chamber which includes electrodes, wherein the chamber has a geometric factor (cm?1) defined by the quotient of the electrode gap squared (cm2) divided by the chamber volume (cm3), wherein the geometric factor is less than or equal to 0.1 cm?1, wherein the suspension of the vesicles and the exogenous material is in a medium which is adjusted such that the medium has conductivity in a range spanning 50 microSiemens/cm to 500 microSiemens/cm, wherein the suspension is enclosed in the chamber during treatment, and b. treating the suspension enclosed in the chamber with one or more pulsed electric fields.Type: GrantFiled: April 18, 2018Date of Patent: February 14, 2023Assignee: CELLECTIS S.A.Inventors: Richard E Walters, Alan D King
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Publication number: 20200080073Abstract: An electroporation apparatus and its novel chamber with inlet ports for mixing cells and exogenous material. The inlet ports are oriented in nonparallel to each other immediately adjacent at the same top comer of the first wall of the chamber. The mixing chamber comprises successive wall sections, two curved walls at its bottom; the first curved comer is on the same side of the chamber where the liquids enter the chamber, and directs the liquids to the second curved comer at the opposing side of the chamber, which in turn further redirects the mixing to the first curved corner. The direction of the liquid flow mixture change direction at least twice into the mixing chamber.Type: ApplicationFiled: October 17, 2019Publication date: March 12, 2020Applicant: CELLECTIS S. A.Inventors: Alan D. King, Richard E. Walters, Stephen B. Deitz, Donald J. Rodis, Derin C. Walters
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Patent number: 10464036Abstract: A catalyst regenerator for combusting carbonaceous deposits from a catalyst comprising a first chamber which comprises a catalyst inlet for feeding spent catalyst with carbonaceous deposits to said first chamber, a supplemental fuel gas distributor, and a distributor for an oxygen containing gas for distributing oxygen containing gas into said first chamber to contact said spent catalyst and combust carbonaceous deposits and supplemental fuel which further deactivates the spent catalyst and generates flue gas; a riser section extending from said first chamber for transporting the spent catalyst and the flue gas, the riser section comprising an outer wall, at least one slot in the outer wall, and a riser termination device which comprises a substantially internally flat cover plate, at least one arm extending from the cover plate, wherein the arm extends about the slot from the outer wall, the arm comprising an outer shell that encloses the arm and wherein no internal portion of the cover plate extends above aType: GrantFiled: September 28, 2016Date of Patent: November 5, 2019Assignee: Dow Global Technologies LLCInventors: Matthew T. Pretz, Don F. Shaw, Richard E. Walter, Madhusudhan Kodam
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Publication number: 20180264424Abstract: A catalyst regenerator for combusting carbonaceous deposits from a catalyst comprising a first chamber which comprises a catalyst inlet for feeding spent catalyst with carbonaceous deposits to said first chamber, a supplemental fuel gas distributor, and a distributor for an oxygen containing gas for distributing oxygen containing gas into said first chamber to contact said spent catalyst and combust carbonaceous deposits and supplemental fuel which further deactivates the spent catalyst and generates flue gas; a riser section extending from said first chamber for transporting the spent catalyst and the flue gas, the riser section comprising an outer wall, at least one slot in the outer wall, and a riser termination device which comprises a substantially internally flat cover plate, at least one arm extending from the cover plate, wherein the arm extends about the slot from the outer wall, the arm comprising an outer shell that encloses the arm and wherein no internal portion of the cover plate extends above aType: ApplicationFiled: September 28, 2016Publication date: September 20, 2018Applicant: Dow Global Technologies LLCInventors: Matthew T. Pretz, Don F. Shaw, Richard E. Walter, Madhusudhan Kodam
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Publication number: 20180237765Abstract: An object of the invention is to provide an electroporation method for treating vesicles with exogenous material for insertion of the exogenous material into the vesicles which includes the steps of: a. retaining a suspension of the vesicles and the exogenous material in a treatment volume in a chamber which includes electrodes, wherein the chamber has a geometric factor (cm?1 ) defined by the quotient of the electrode gap squared (cm2) divided by the chamber volume (cm3), wherein the geometric factor is less than or equal to 0.1 cm?1, wherein the suspension of the vesicles and the exogenous material is in a medium which is adjusted such that the medium has conductivity in a range spanning 50 microSiemens/cm to 500 microSiemens/cm, wherein the suspension is enclosed in the chamber during treatment, and b. treating the suspension enclosed in the chamber with one or more pulsed electric fields.Type: ApplicationFiled: April 18, 2018Publication date: August 23, 2018Applicant: Cellectis S.A.Inventors: Richard E Walters, Alan D King
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Patent number: 10016736Abstract: A cyclonic reactor vessel comprising: a primary cyclonic separation device disposed within the shell and having an outlet; a plurality of secondary cyclones, said secondary cyclones being disposed within the shell, and each of said secondary cyclones having a body, an inlet and an outlet; wherein the outlet of the primary cyclonic separation device is connected to the inlet of at least one secondary cyclone; a first plenum having a skirt and a floor forming a sealed annular chamber within the shell; a second plenum having a smaller volume than a volume of the first plenum; and a secondary cyclone support system minimizing or eliminating mechanical thermal stresses; and wherein the outlets of the plurality of secondary cyclones are fluidly connected to the second plenum is provided.Type: GrantFiled: September 22, 2014Date of Patent: July 10, 2018Assignee: Dow Global Technologies LLCInventors: Matthew Pretz, Don F. Shaw, Richard E. Walter
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Patent number: 9982251Abstract: An object of the invention is to provide an electroporation method for treating vesicles with exogenous material for insertion of the exogenous material into the vesicles which includes the steps of: a. retaining a suspension of the vesicles and the exogenous material in a treatment volume in a chamber which includes electrodes, wherein the chamber has a geometric factor (cm.sup.?1) defined by the quotient of the electrode gap squared (cm.sup.2) divided by the chamber volume (cm.sup.3), wherein the geometric factor is less than or equal to 0.1 cm.sup.?1, wherein the suspension of the vesicles and the exogenous material is in a medium which is adjusted such that the medium has conductivity in a range spanning 50 microSiemens/cm to 500 microSiemens/cm, wherein the suspension is enclosed in the chamber during treatment, and b. treating the suspension enclosed in the chamber with one or more pulsed electric fields.Type: GrantFiled: March 15, 2004Date of Patent: May 29, 2018Assignee: CELLECTIS S.A.Inventors: Richard E. Walters, Alan D. King
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Patent number: 9889418Abstract: A fluidized fuel gas combustor system for a catalytic dehydrogenation process comprising a vessel having a lower portion and an upper portion; a plurality of air injection diffusers located in the lower portion of the vessel; a plurality of fuel gas injection diffusers located on fuel gas distributors disposed in the vessel and spaced apart from and above a plurality of air injection diffusers, wherein the fuel gas diffusers are placed in a manner to maximize even mass distribution of a fuel gas injected through the fuel gas diffusers in the vessel, wherein each fuel distributor comprises a tube having a plurality of fuel gas injection diffusers; and one or more grid assemblies disposed in the vessel spaced above the fuel gas distributors is provided.Type: GrantFiled: September 29, 2015Date of Patent: February 13, 2018Assignee: Dow Global Technologies LLCInventors: Matthew T. Pretz, Richard E. Walter, Don F. Shaw, Fermin A. Sandoval, Liwei Li
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Publication number: 20170087529Abstract: A catalyst regenerator for combusting carbonaceous deposits from a catalyst comprising a first chamber which comprises a catalyst inlet for feeding spent catalyst with carbonaceous deposits to said first chamber, a supplemental fuel gas distributor, and a distributor for an oxygen containing gas for distributing oxygen containing gas into said first chamber to contact said spent catalyst and combust carbonaceous deposits and supplemental fuel which further deactivates the spent catalyst and generates flue gas; a riser section extending from said first chamber for transporting the spent catalyst and the flue gas, the riser section comprising an outer wall, at least one slot in the outer wall, and a riser termination device which comprises a substantially internally flat cover plate, at least one arm extending from the cover plate, wherein the arm extends about the slot from the outer wall, the arm comprising an outer shell that encloses the arm and wherein no internal portion of the cover plate extends above aType: ApplicationFiled: September 30, 2015Publication date: March 30, 2017Inventors: Matthew T. Pretz, Don F. Shaw, Richard E. Walter, Madhusudhan Kodam
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Publication number: 20170087528Abstract: A fluidized fuel gas combustor system for a catalytic dehydrogenation process comprising a vessel having a lower portion and an upper portion; a plurality of air injection diffusers located in the lower portion of the vessel; a plurality of fuel gas injection diffusers located on fuel gas distributors disposed in the vessel and spaced apart from and above a plurality of air injection diffusers, wherein the fuel gas diffusers are placed in a manner to maximize even mass distribution of a fuel gas injected through the fuel gas diffusers in the vessel, wherein each fuel distributor comprises a tube having a plurality of fuel gas injection diffusers, one or more optional grid assemblies disposed in the vessel spaced apart from and above the plurality of air injection diffusers and paced apart from and below the fuel gas distributors to maximize even air mass distribution; and one or more grid assemblies disposed in the vessel spaced above the fuel gas distributors is provided.Type: ApplicationFiled: September 29, 2015Publication date: March 30, 2017Inventors: Matthew T. Pretz, Richard E. Walter, Don F. Shaw, Fermin A. Sandoval, Liwei Li
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Patent number: 9597652Abstract: A catalyst regenerator for combusting carbonaceous deposits from a catalyst comprising a first chamber which comprises a catalyst inlet for feeding spent catalyst with carbonaceous deposits to the first chamber, a supplemental fuel gas distributor, and a distributor for distributing oxygen containing gas into the first chamber; a riser section extending from the first chamber for transporting the spent catalyst and the flue gas, the riser section comprising an outer wall, at least one slot in the outer wall, and a riser termination device which comprises a substantially internally flat cover plate, at least one arm extending from the cover plate, wherein the arm extends about the slot from the outer wall, the arm comprising an outer shell that encloses the arm and wherein no internal portion of the cover plate extends above an upper surface of the outer shell of the at least one arm is provided.Type: GrantFiled: September 30, 2015Date of Patent: March 21, 2017Assignee: Dow Global Technologies LLCInventors: Matthew T. Pretz, Don F. Shaw, Richard E. Walter, Madhusudhan Kodam
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Publication number: 20160256840Abstract: A cyclonic reactor vessel comprising: a primary cyclonic separation device disposed within the shell and having an outlet; a plurality of secondary cyclones, said secondary cyclones being disposed within the shell, and each of said secondary cyclones having a body, an inlet and an outlet; wherein the outlet of the primary cyclonic separation device is connected to the inlet of at least one secondary cyclone; a first plenum having a skirt and a floor forming a sealed annular chamber within the shell; a second plenum having a smaller volume than a volume of the first plenum; and a secondary cyclone support system minimizing or eliminating mechanical thermal stresses; and wherein the outlets of the plurality of secondary cyclones are fluidly connected to the second plenum is provided.Type: ApplicationFiled: September 22, 2014Publication date: September 8, 2016Inventors: Matthew Pretz, Don F. Shaw, Richard E. Walter
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Patent number: 9370759Abstract: Embodiments include a reactor and feed distribution assembly. The reactor and feed distribution assembly can include a reactor vessel, a gaseous feed conduit, a catalyst feed conduit, a catalyst feed conduit housing, and a catalyst backflow diverter.Type: GrantFiled: September 16, 2013Date of Patent: June 21, 2016Assignee: Dow Global Technologies LLCInventors: Matthew Pretz, Don F. Shaw, Richard E. Walter, Mark Stewart
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Publication number: 20150231586Abstract: Embodiments include a reactor and feed distribution assembly. The reactor and feed distribution assembly can include a reactor vessel, a gaseous feed conduit, a catalyst feed conduit, a catalyst feed conduit housing, and a catalyst backflow diverter.Type: ApplicationFiled: September 16, 2013Publication date: August 20, 2015Applicants: Dow Global Technologies LLC, Carmagen EngineeringInventors: Matthew Pretz, Don F. Shaw, Richard E. Walter, Mark Stewart
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Patent number: 8075696Abstract: This invention relates to a method for removing fouling from a heat transfer surface, such as a heat exchanger. The method involves conducting a vapor containing a scouring material to the heat transfer surface and contacting the scouring material with the foulant, the heat transfer surface, or both. Scouring material and removed foulant can be recovered and conducted away.Type: GrantFiled: June 13, 2007Date of Patent: December 13, 2011Assignee: ExxonMobil Chemical Patents Inc.Inventors: James H. Beech, Richard E. Walter
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Publication number: 20110282265Abstract: An object of the invention is to provide a method and apparatus for the delivery of polynucleotide vaccines into mammalian skin cells to increase T cell response and reduce pain and discomfort due to long electric waveform application and due to muscle contractions. The method includes administering a polynucleotide vaccine into the skin at an administration site, (b) applying a needle electrode to the skin in the vicinity to the administration site, and (c) applying a sequence of at least three single, operator-controlled, independently programmed, narrow interval electrical waveforms, which have pulse intervals that are less than 100 milliseconds, to deliver the 15 polynucleotide vaccine into the skin cells by electroporation.Type: ApplicationFiled: May 20, 2008Publication date: November 17, 2011Inventors: Richard E. Walters, Derin C. Walters, Alan D. King, Anna-Karin Roos
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Publication number: 20110166501Abstract: An object of the invention is to provide a method and apparatus for the delivery of polynucleotide vaccines into mammalian skin cells to increase T cell response and to reduce pain and discomfort due to long electric waveform application and due to muscle contractions. The method for the delivery of polynucleotide vaccines into mammalian skin cells includes the steps of: (a.) administering a polynucleotide vaccine into the skin at an administration site, (b.) applying a needle electrode to the skin in the vicinity to the administration site, and (c.) applying a sequence of at least three single, operator-controlled, independently programmed, narrow interval electrical waveforms, which have pulse intervals that are less than 100 milliseconds, to deliver the polynucleotide vaccine into the skin cells by electroporation.Type: ApplicationFiled: March 15, 2011Publication date: July 7, 2011Inventors: Richard E. Walters, Derin C. Walters, Alan D. King, Anna-Karin Roos
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Patent number: 7935857Abstract: A gas-solids reaction system is provided for improving product recovery in a multiple reactor reaction system. The solids of the product gas-solids flows from the multiple reactors are separated out in a separation vessel having a baffled transition zone. Additional product vapor is stripped from the solids as the solids pass through the baffled transition zone. The solids are then returned to the multiple reactors.Type: GrantFiled: February 14, 2007Date of Patent: May 3, 2011Assignee: ExxonMobil Chemical Patents Inc.Inventors: James H. Beech, Richard E. Walter, Arun K. Sharma, Jeffrey S. Smith
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Patent number: 7824901Abstract: An apparatus is provided for carrying out fusion of biological cells (10) and includes a base member (24) on which a conductive outer electrode (18) is supported and has an outer electrode radius (r2) and has an electrode height (19). A conductive inner electrode (20) is supported on the base member (24) and has an inner electrode radius (r1) and also has the electrode height (19). The outer and inner electrodes (18,20) are spaced apart from each other by a gap which defines a fusion chamber (14). The inner electrode radius (r1), the outer electrode radius (r2), and the gap are selected in accordance with a predetermined range of selectable ratios (r1/r2) in a range from 0.7 to 0.Type: GrantFiled: December 1, 2003Date of Patent: November 2, 2010Assignee: Cyto Pulse Sciences, Inc.Inventor: Richard E. Walters
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Patent number: 7767870Abstract: A gas-solids reaction system with termination devices to connect a riser with one or more separation devices. The termination devices have a radius of curvature that is at least 1.0 times as great as the diameter of the conduit forming the termination device. The termination devices can be openly or closely coupled to the separation devices.Type: GrantFiled: August 31, 2005Date of Patent: August 3, 2010Assignee: ExxonMobil Chemical Patents Inc.Inventors: Rutton D. Patel, Arun K. Sharma, E. Nicholas Jones, James H. Beech, Jr., Richard E. Walter, Donald F. Shaw, Kenneth R. Clem, Nicolas P. Coute